Imaging Series - Dr Hao F. Zhang

"Developing optical imaging technologies to identify disease biomarkers"

Hao F. Zhang Ph.D.
Department of Biomedical Engineering, Northwestern University

Abstract: My lab seeks to develop optical imaging technologies to fill the gaps in both clinical diagnoses and fundamental investigations. The current projects are (1) to develop optical coherence tomography (OCT) technologies that can extract physiological and pathological information beyond high-quality anatomical imaging. To this end, we developed visible-light OCT or vis-OCT to quantify retinal oxygen metabolic signatures in diabetic retinopathy and macular degeneration. We are also examining optical signatures of earliest pathological alterations in glaucoma and geography atrophy; (2) to push super-resolution microscopy into new depth. We combined patterned illumination with two-photon microscopy to achieve this goal; (3) to add molecular specificity to photon localization microscopy through stochastic spectroscopic analysis. This newly developed technology demonstrated a spatial resolution of 4 nm and a potential to image biomolecules without fluorescent labeling. In this talk, I will brief our work in this three areas with applications from genome imaging at 10 nm scale to clinical ophthalmology.

Monday 12^th September at 1pm

OHRI Lecture Theatre, UCL Institute of Ophthalmology

All welcome

Hosted by Chris Dainty (c.dainty@ucl.ac.uk)

IoO-Department of Visual Neuroscience