Department of Neuroinflammation

Head of Department: Professor Olga Ciccarelli

The main focus of the department is research into multiple sclerosis (MS) and we employ a broad range of basic and clinical methods, including clinical therapeutic trials.

The department consists of over 82 investigators organized into nine research groups, with over 20 PhD students. The department is recognized worldwide as a centre of excellence for MS research, building on the strong foundation established by Prof. Ian McDonald, memorialized in the internationally-accepted “McDonald Criteria” for disease diagnosis.

The department is also closely affiliated with the Queen Square Multiple Sclerosis Centre and UCLH.

Our research activity truly spans “from bench to bedside and back again”, described in outline below, and in more detail on the personal websites of the members.

Cell Signalling

Investigating microglial signalling cascades using cell-based systems to dissect out the pathways of neuronal death in neurodegenerative disease.

Experimental Neuroinflammation Group

Study of the fundamental mechanisms underlying central and peripheral neuroinflammation, with the goal of developing novel therapeutic strategies for protection of neural function and structure.

MR Physics - NMR Research Unit

The NMR Research Unit is focused on developing, implementing and translating methods for studying a number of pathophysiological processes occurring in multiple sclerosis.

Neuroimaging in MS

Using magnetic resonance imaging (MRI) to provide new insights into the pathogenesis and pathophysiology of MS, and translate these into more effective treatments and better care for people with MS.

Predicting treatment response in MS using MRI

Using magnetic resonance imaging (MRI) genetics and neurofilaments information to develop a computer tool that will enable doctors to predict which medicines individuals with MS will respond better to.

Neuroimmunology

Dedicated to the analysis of cerebrospinal fluid and serum to aid in the diagnosis of neurological diseases such as, inflammatory demyelinating disorders and dementia.

Trials in Progressive Multiple Sclerosis

Conducting clinical trials in patients with secondary progressive MS, examining the efficacy of various therapies at slowing the rate of brain atrophy (shrinkage).

Use of MRI in Clinical Drug Trials for MS

Providing management and analysis expertise to physicians and industry using MRI measurements as part of multicentre clinical drug trials for multiple sclerosis.

Contacts

If you would like to know more about our activities, or you would like to join or support our research, please contact either the members of staff directly (contact details on their websites), or Prof. Olga Ciccarelli (+44 (0) 203 108 7415)

The department is looked after by our manager Judith Jolleys, and the departmental assistant Heather Ormsby.