The Sleigh Lab works to understand mechanisms underlying hereditary peripheral nerve conditions, such as Charcot-Marie-Tooth disease (CMT), amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Established in 2019, we are part of the Department of Neuromuscular Diseases and based on the 5th floor of Queen Square House. Our research is currently principally funded by the Medical Research Council UK.
We are fascinated by how mutations in widely expressed genes can cause selective peripheral nerve pathology. We believe that by improving our understanding of the molecular and cellular mechanisms underpinning this phenomenon, we will be able to develop novel, targeted therapies for these devastating diseases.