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UCL Queen Square Institute of Neurology

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Neurosurgery

 

Skull and chest radiographs pre & post intervention*

Using surgical techniques to correct neurological problems, and developing new ways to repair brain injury

Lead:

  Mr Ahmed Toma
  Mr Lawrence Watkins

Research Team:

 Mr Hani Marcus
 Dr Linda D’Antona

Research Goals

 Hydrocephalis and cerebrospinal fliud disturbances:
  Intracranial pressure research, CSF biomarkers.
  Normal pressure hydrocephalus clinical studies.
 Cerebrovascular surgery research:
  Brain tissue oxygen monitoring in Subarachnoid haemorrhage
  patients.
  Study of biomarkers in vasospasm patients.
  Studies of external ventricular and lumbar drainage in Subarachnoid
  haemorrhage patients.
  Incidental aneurysms.
  Aneurysm surgery research.

Funded Research Projects

  • Study of intracranial pressure dynamics
  • Studying cerebrospinal fluid biomarkers
  • Imaging studies in normal pressure hydrocephalus
  • Recruiting to BASICS trial and TOPSAT2 to study cerebrovascular disease and hydrocephalus
  • Study of CSF biomarkers in SAH
Recent publications from Neurosurgery

 

2020

Cabrilo I, Craven CL, Abuhusain H, Pradini-Santos L, Asif H, Marcus HJ, Reddy U, Watkins LD, Toma AK
Neuronavigation-assisted bedside placement of bolt external ventricular drains in the intensive care setting: a technical noteActa Neurochir, 30 October 2020
https://doi.org/10.1007/s00701-020-04634-w

D'Antona L, Craven CL, Merchan MAJ, Thompson SD, Bremner F, Thorne L, Matharu M, Watkins L, Toma A
Paradoxical response of intracranial pressure to shunt valve setting adjustments
Acta Neurochirurgica: the European journal of neurosurgery 01 Oct 2020 pages2451–2458(2020)
https://doi.org/10.1007/s00701-020-04462-y

Funnell JP, D'Antona L, Craven C, Thorne L, Watkins L, Toma A
Ultra-low pressure hydrocephalic state in NPH: benefits of therapeutic siphoning with adjustable anti-gravity valves
Acta Neurochirurgica: the European journal of neurosurgery 02 Sep 2020
https://doi.org/10.1007/s00701-020-04596-z

D'Antona L, Thompson SD, Thorne L, Watkins L, Toma A
Letter: thirty-day hospital readmission and surgical complication rates for shunting in normal pressure hydrocephalus: a large national database Analysis
Neurosurgery, Dec 2020; 87(6): E707–E708,
https://doi.org/10.1093/neuros/nyaa386

Craven CL, Pradini-Santos L, Goel A, Thorne L, Watkins LD, Toma AK. Approach to slitlike ventricles: parietal-occipital versus frontal Burr catheter entry sites. World Neurosurgery, online 1st January 2020.
 

Craven CL, Ramkumar R, D’Antona L, Thompson SD, Thorne L, Watkins LD, Toma AK. Natural history of ventriculomegaly in adults: A cluster analysis. Journal of Neurosurgery 2020; 132(3):741-748.

 

D’Antona L, Blamey SC, Craven CL, Sewell D, Manohara S, Leemans M, Worby S, Thompson SD, Golahmadi AK, Funnell JP, Thorne L, Watkins LD, Luorna AMV, Toma AK. Early postoperative outcomes of normal pressure hydrocephalus: results of a service evaluation. Journal of Neurosurgical Anesthesiology, online 1st January

 

D’Antona L, Craven CL, Merchan MAJ, Thompson SD, Bremner F, Thorne L, Matharu M, Watkins L, Toma A.  Paradoxical response of intracranial pressure to shunt valve setting adjustments.  Acta Neurochirurgica: the European Journal of Neurosurgery, online 11th June 2020 

 

Dyson EW, Chari A, Toma AK, Thorne LW, Watkins LD.  Failed Foramen Magnum decompression in Chiari I malformation is associated with failure to restore normal intracranial compliance:  An observational cohort study.  Neurosurgery, online 1st June 2020

Muirhead WR, Grover PJ, Toma AK, Stoyanov D, Marcus HJ, Murphy M.  Adverse intraoperative events during surgical repair of ruptured cerebral aneurysms:  a systematic review.  Neurosurgical Review, online 16th June 2020

Pradini-Santos L, Craven CL, Watkins LD, Toma AK.  Ventriculoatrial shunt catheter tip migration causing tricuspid regurgitation:  Case Report and review of the literature.  World Neurosurgery 136:83-89, 1st April 2020

 

2018

Asif H, Craven CL, Siddiqui AH, Shah SN, Matloob SA, Thorne L, Robertson F, Watkins LD, Toma AK. Idiopathic intracranial hypertension: 120-day clinical, radiological, and manometric outcomes after stent insertion into the dural venous sinus. J Neurosurg 2018; 129(3):723-731.

Craven CL, Chapman MD, D'Antona L, Thompson SD, Lakdawala N, Zetterberg H, Watkins LD, Toma AK. Lumbar drains can affect CSF biomarker levels. Journal of Clinical Pathology, 2018 in press.

Alg VS, Ke X, Grieve J, Bonner S, Walsh DC, Bulters D, Kitchen N, Houlden H, Werring DJ. Association of functional MMP-2 gene variant with intracranial aneurysms: case-control genetic association study and meta-analysis. British Journal of Neurosurgery, online 15 Jan 2018.

Craven CL, Baudracco I, Thompson SD, Thorne L, Watkins LD, Toma AK. Transtentorial distortion syndrome: consistent complication following lateral and fourth ventricular shunting in adults. World Neurosurgery 2018; 110:e514-e519.

Funnell JP, Craven CL, D’Antona L, Thompson SD, Chari A, Thorne L, Watkins LD, Toma AK. Intracranial pressure in patients with papilloedema. Acta Neurologica Scandinavica, online 12 March 2018.

2017

Al-Mousa A, Bose G, Hunt K, Toma AK. Adenosine-assisted neurovascular surgery: initial case series and review of literature. Neurosurgical Review, online 22 July 2017doi: 10.1007/s10143-017-0883-3. [Epub ahead of print]

Asif H, Craven CL, Siddiqui AH, Shah SN, Matloob SA, Thorne L, Robertson F, Watkins LD, Toma AK.  Idiopathic intracranial hypertension: 120-day clinical, radiological, and manometric outcomes after stent insertion into the dural venous sinus.  Journal of Neurosurgery, online 6 October 2017. DOI: 10.3171/2017.4.JNS162871

Craven CL, Baudracco I, Zetterberg H, Lunn MPT, Chapman MD, Lakdawala N, Watkins LD, Toma AK.  The predictive value of T-tau and AB1-42 levels in idiopathic normal pressure hydrocephalus.  Acta Neurochirurgica 2017; 159(12):2293-2300.  DOI:  10.1007/s00701-017-3314-x

Craven CL, Baudracco I, Thompson SD, Thorne L, Watkins LD, Toma AK.  Transtentorial distortion syndrome:  a consistent complication following lateral and fourth ventricular shunting in adults.  World Neurosurgery, online 15 November 2017.  DOI:  10.1016/j.wneu.2017.11.032

Hostettler Moreno I, Alg V, Shahi N, Jichi F, Bonner S, Walsh D, Bulters D, Kitchen N Brown M, Houlden H et al. Characteristics of unruptured compared to ruptured intracranial aneurysms: A multicentre case-control study. Neurosurgery,2017 Jul 25. doi: 10.1093/neuros/nyx365. [Epub ahead of print].

Matharu MS, Miller S, Lagrata S, Watkins L.  Occipital nerve stimulation for medically refractory chronic paroxysmal hemicrania.  Headache 2017; 57(10):1610-1613. DOI: 10.1111/head.13187

Matloob SA, Toma AK, Thompson SD, Gan CL, Robertson F, Thorne L, Watkins LD. Effect of venous stenting on intracranial pressure in idiopathic intracranial hypertension. Acta Neurochirurgica 2017 Aug;159(8):1429-1437. doi: 10.1007/s00701-017-3229-6. Epub 2017 May 31.

Thompson SD, Shand Smith JD, Khan AA, Luoma AMV, Toma AK, Watkins LD. Shunting of the over 80s in normal pressure hydrocephalus. Acta Neurochirurgica 2017; 159(6):987-994 doi: 10.1007/s00701-017-3171-7. Epub 2017 Apr 18.

Thompson SD, Coutts A, Craven CL, Toma AK, Thorne LW, Watkins LD. Elective ICP monitoring: how long is long enough? Acta Neurochirurgica 2017; 159(3):485-490 doi: 10.1007/s00701-016-3074-z. Epub 2017 Jan 20.

2016

Craven CL, Toma AK, Watkins LD. Persistent hydrocephalus due to postural activation of a ventricular shunt anti-gravity device. Journal of Clinical Neuroscience 2017; 37:91-95 doi: 10.1016/j.jocn.2016.11.004. Epub 2016 Nov 24.

Craven CL, Toma AK, Mostafa T, Patel N, Watkins LD. The predictive value of DESH for shunt responsiveness in idiopathic normal pressure hydrocephalus. J Clin Neurosci 2016;34:294-298. doi: 10.1016/j.jocn.2016.09.004. Epub 2016 Sep 28.

Rojas-Villabona A, Kitchen N, Paddick I. Investigation of dosimetric differences between the TMR 10 and convolution algorithm for Gamma Knife stereotactic radiosurgery. J Appl Clin Med Phys. 2016 Nov 8;17(6):6347. doi: 10.1120/jacmp.v17i6.6347.

Further information

* Craven et al (2017). Persistent hydrocephalus due to postural activation of a ventricular shunt anti-gravity device. Journal of Clinical Neuroscience, Volume 37, March 2017, Pages 91-95. https://doi.org/10.1016/j.jocn.2016.11.004