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UCL Queen Square Institute of Neurology

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Neuroradiology

 

Voxel-based morphometry results showing (top) grey matter volume loss and (bottom) white matter volume loss in symptomatic ADAD mutation carriers compared to controls*

Establishing and applying imaging methods and biomarkers to transform the diagnosis, management and treatment of neurological and neurosurgical diseases

Lead:

Professor Tarek Yousry, Dr med Habil, FRCR

Research Team:

Research Goals

  • Research involving imaging method development and patient-cohort imaging studies covers a wide range of neurological and neurosurgical diseases, including neurovascular disorders, neurooncology, neurodegeneration and Neuroinflammation, as well muscle and peripheral nerves (neuromuscular) disorders. Our aim is to facilitate rapid translation of innovations, including intraoperative imaging, into the clinical environment.

Funded Research Projects

  • Secondary prevention of Alzheimer’s disease. Funded by the EU
  • GLINT: GlucoCEST imaging of neoplastic tumours. Funding from EC-H2020.
  • A gold standard perfusion phantom for quantitative MRI. Funded by SBRI NHS England.
  • High dose Simvastatin treatment for secondary progressive multiple sclerosis: impact on vascular perfusion and oxidative damage. Funded by the MS Society of GB & NI
  • Feasibility of microstructural and metabolic MRI fingerprinting of human gliomas. Funded by the NIHR BRC
  • Multi-centre optimization and harmonization of MRI image acquisition schemes: a UK-wide coordinated approach to advanced neuroimaging in dementia. Funded by Alzheimer’s Research UK
  • Multi-user ultra-high field clinical imaging research centre for London. Funded by the Wellcome Trust
  • Non-Invasive Imaging of glymphatic clearance: a novel strategy for the early diagnosis of Alzheimer's disease. Funded by EPSRC.
  • Imaging research to facilitate treatments for multiple sclerosis MS Society of GB
  • MRC centre for Neuromuscular disease, MRC
  • MYO-MRI COST Action- BM1304
Recent publications from Neuroradiology

2020

Kanber B, Morrow JM, Klickovic U, Wastling S, Shah S, Fratta P, McDowell AR, Hall MG, Clark CA, Muntoni F, Reilly MM, Hanna MG, Alexander DC, Yousry T, Thornton JS
Musclesense: a Trained, Artificial Neural Network for the Anatomical Segmentation of Lower Limb Magnetic Resonance Images in Neuromuscular Diseases
Neuroinformatics 05 Sep 2020
https://doi.org/10.1007/s12021-020-09485-5

Patodia S, Tachrount M, Somani A, Scheffer I, Yousry T, Golay X, Sisodiya S, Thom M
In response to 'Volume loss and altered neuronal composition in the brainstem reticular zone may not cause sudden unexpected death in epilepsy'.
Neuropathol Appl Neurobiol 07 Aug 2020
https://doi.org/10.1111/nan.12653

Goodkin O, Pemberton HG, Vos SB, Prados F, Das RK, Moggridge J, De Blasi B, Bartlett P, Williams E, Campion T, Haider L, Pearce K, Bargallό N, Sanchez E, Bisdas S, White M, Ourselin S, Winston GP, Duncan JS, Cardoso J, Thornton JS, Yousry TA, Barkhof F
Clinical evaluation of automated quantitative MRI reports for assessment of hippocampal sclerosis
Eur Radiol 04 Aug 2020
https://doi.org/10.1007/s00330-020-07075-2

Shah S, Morrow JM, Sinclair CDJ, Reilly MM, Thornton JS, Lunn MP, Yousry TA
MRI quantifies lumbosacral nerve root and sciatic nerve hypertrophy in chronic inflammatory demyelinating polyradiculoneuropathy
European Journal of Radiology 130:7
https://doi.org/10.1016/j.ejrad.2020.109164

Kim M, Kujawa A, Battiston M, Demetriou E, Schneider T, Collorone S, Tur C, Evans V, Okuchi S, Atkinson D, Wheeler-Kingshott C, Golay X
Translating pH-sensitive PROgressive saturation for Quantifying Exchange using Saturation Times (PRO-QUEST) MRI to a 3T Clinical Scanner
Magnetic Resonance in Medicine 01 Oct 2020
https://doi.org/10.1002/mrm.28229

Mutsaerts HJMM, Petr J, Groot P, Vandemaele P, Ingala S, Robertson AD.......... Golay X, Thomas DL, de Vita E, Bjørnerud A, Nederveen A, Hendrikse J, Asllani I, Barkhof F
ExploreASL: an image processing pipeline for multi-center ASL perfusion MRI studies
Neuroimage 117031 01 Oct 2020
https://doi.org/10.1016/j.neuroimage.2020.117031

Pang R, Martinello KA, Meehan C, Avdic-Belltheus A, Lingam I, Sokolska M, Mutshiya T, Bainbridge A, Golay X, Robertson NJ
Proton Magnetic Resonance Spectroscopy Lactate/N-Acetylaspartate Within 48 h Predicts Cell Death Following Varied Neuroprotective Interventions in a Piglet Model of Hypoxia–Ischemia With and Without Inflammation-Sensitization
Frontiers in Neurology 4 Sept 2020; 11:883
doi: 10.3389/fneur.2020.00883

Golay X, Demetriou E, Kujawa A
Pulse sequences for measuring exchange rates between proton species: from unlocalised NMR spectroscopy to chemical exchange saturation transfer imaging
Progress in Nuclear Magnetic Resonance Spectroscopy 10 Aug 2020
https://doi.org/10.1016/j.pnmrs.2020.06.001

Wijburg MT, Warnke C, McGuigan C, Koralnik IJ, Barkhof F, Killestein J, Wattjes MP
Pharmacovigilance during treatment of multiple sclerosis: early recognition of CNS complicationsJ Neurol Neurosurg Psychiatry 23 Nov 2020
http://dx.doi.org/10.1136/jnnp-2020-324534

ibaldi F, Altomare D, Jovicich J, Ferrari C, Picco A, Pizzini FB ....... Barkhof F, .......Richardson JC, Frisoni GB, Marizzoni M
Accuracy and reproducibility of automated white matter hyperintensities segmentation with lesion segmentation tool: A European multi-site 3T study
Magn Reson Imaging 18 Nov 2020
https://doi.org/10.1016/j.mri.2020.11.008

Toorop AA, van Lierop ZYG, Strijbis EEM, Teunissen CE, Petzold A, Wattjes MP, Barkhof F, de Jong BA, van Kempen ZLE, Killestein J
Mild progressive multifocal leukoencephalopathy after switching from natalizumab to ocrelizumab
Neurol Neuroimmunol Neuroinflamm 8(1):Jan 2021
DOI: https://doi.org/10.1212/NXI.0000000000000904

Hong S, Prokopenko D, Dobricic V, Kilpert F, Bos I, Vos SJB, ...... Barkhof F, Zetterberg H, Lovestone S, Streffer J, Wittig M, Franke A, Tanzi RE, Visser PJ, Bertram L
Genome-wide association study of Alzheimer’s disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset
Translational Psychiatry 10(1):01 Dec 2020
https://doi.org/10.1038/s41398-020-01074-z

Wolters EE, van de Beek M, Ossenkoppele R, Golla SSV, Verfaillie SCJ, Coomans EM, Timmers T, Visser D, Tuncel H, Barkhof F, Boellaard R, Windhorst AD, van der Flier WM, Scheltens PH, Lemstra AW, van Berckel BNM
Tau PET and relative cerebral blood flow in Dementia with Lewy bodies: A PET study
NeuroImage: Clinical 102504 Article number 102504 19 Nov 2020
https://doi.org/10.1016/j.nicl.2020.102504

Singleton EH, Pijnenburg YAL, Sudre CH, Groot C, Kochova E, Barkhof F, La Joie R, Rosen HJ, Seeley WW, Miller B, Cardoso MJ, Papma J, Scheltens P, Rabinovici GD, Ossenkoppele R
Investigating the clinico-anatomical dissociation in the behavioral variant of Alzheimer disease
Alzheimer's Research and Therapy 12(1):14 Nov 2020
https://doi.org/10.1186/s13195-020-00717-z

Lam KH, Meijer KA, Loonstra FC, Coerver EME, Twose J, Redeman E, Moraal B, Barkhof F, de Groot V, Uitdehaag BMJ, Killestein J
Real-world keystroke dynamics are a potentially valid biomarker for clinical disability in multiple sclerosis
Multiple Sclerosis Journal 135245852096879 05 Nov 2020
https://doi.org/10.1177/1352458520968797

Solanky BS, John NA, DeAngelis F, Stutters J, Prados F, Schneider T, Parker RA, Weir CJ, Monteverdi A, Plantone D, Doshi A, MacManus D, Marshall I, Barkhof F, Gandini Wheeler-Kingshott CAM, Chataway J, MS-SMART Investigators
NAA is a Marker of Disability in Secondary-Progressive MS: A Proton MR Spectroscopic Imaging Study
American Journal of Neuroradiology 05 Nov 2020
DOI: https://doi.org/10.3174/ajnr.A6809

Ingala S, Mazzai L, Sudre CH, Salvadó G, Brugulat-Serrat A, Wottschel V, Falcon C, Operto G, Tijms B, Gispert JD, Molinuevo JL, Barkhof F
The relation between APOE genotype and cerebral microbleeds in cognitively unimpaired middle- and old-aged individuals
Neurobiology of Aging 95:104-114 01 Nov 2020
https://doi.org/10.1016/j.neurobiolaging.2020.06.015

Chételat G, Arbizu J, Barthel H, Garibotto V, Law I, Morbelli S, van de Giessen E, Agosta F, Barkhof F, Brooks DJ, ....... Zetterberg H, Drzezga A
Amyloid-PET and <sup>18</sup>F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias
The Lancet Neurology 19(11):951-962 01 Nov 2020
https://doi.org/10.1016/S1474-4422(20)30314-8

van Duinkerken E, Bernardes G, van Bloemendaal L, Veltman DJ, Barkhof F, Mograbi DC, Gerdes VE, Deacon CF, Holst JJ, Drent ML, Diamant M, Ten Kulve J, IJzerman RG
Cerebral effects of GLP-1 receptor blockade before and after Roux-en-Y Gastric Bypass in obese women: a proof-of-concept resting-state fMRI study
Diabetes Obes Metab 20 Oct 2020
https://doi.org/10.1111/dom.14233

Zhuo Z, Duan Y, Tian D, Wang X, Gao C, Ding J, Zheng F, Zhang T, Zhang X, Barkhof F, Shi FD, Liu Y
Brain structural and functional alterations in MOG antibody disease
Multiple Sclerosis Journal 15 Oct 2020
https://doi.org/10.1177/1352458520964415

Dicks E, van der Flier WM, Scheltens P, Barkhof F, Tijms BM
Single-subject gray matter networks predict future cortical atrophy in preclinical Alzheimer's disease
Neurobiology of Aging 94:71-80 01 Oct 2020
https://doi.org/10.1016/j.neurobiolaging.2020.05.008

Eijgelaar RS, Visser M, Müller DMJ, Barkhof F, Vrenken H, van Herk M, et al
Robust Deep Learning–based Segmentation of Glioblastoma on Routine Clinical MRI Scans Using Sparsified Training
Radiology: Artificial Intelligence 2(5):e190103 30 Sep 2020
https://doi.org/10.1148/ryai.2020190103

Verberk IMW, Thijssen E, Koelewijn J, Mauroo K, Vanbrabant J, de Wilde A, Zwan MD, Verfaillie SCJ, Ossenkoppele R, Barkhof F, van Berckel BNM, Scheltens P, van der Flier WM, Stoops E, Vanderstichele HM, Teunissen CE
Combination of plasma amyloid beta(1-42/1-40) and glial fibrillary acidic protein strongly associates with cerebral amyloid pathology
Alzheimers Res Ther 12(1):118 28 Sep 2020
https://doi.org/10.1186/s13195-020-00682-7

Calvi A, Haider L, Prados F, Tur C, Chard D, Barkhof F
In vivo imaging of chronic active lesions in multiple sclerosis
Multiple Sclerosis Journal 23 Sep 2020
https://doi.org/10.1177/1352458520958589

Leeuwis AE, Hooghiemstra AM, Bron EE, ......Barkhof F, van der Flier WM
Cerebral blood flow and cognitive functioning in patients with disorders along the heart–brain axis: Cerebral blood flow and the heart–brain axis
Alzheimer's and Dementia: Translational Research and Clinical Interventions 13 Sep 2020
https://doi.org/10.1002/trc2.12034

Moccia M, Valsecchi N, Ciccarelli O, Van Schijndel R, Barkhof F, Prados F
Spinal cord atrophy in a primary progressive multiple sclerosis trial: Improved sample size using GBSI
NeuroImage: Clinical 28:09 Sep 2020
https://doi.org/10.1016/j.nicl.2020.102418

Legdeur N, Badissi M, Yaqub M, Beker N, Sudre CH, Ten Kate M, Gordon MF, Novak G, Barkhof F, van Berckel BNM, Holstege H, Muller M, Scheltens P, Maier AB, Visser PJ
What determines cognitive functioning in the oldest-old? The EMIF-AD 90+ Study
The Journals of Gerontology: Series B 08 Sep 2020
https://doi.org/10.1093/geronb/gbaa152

Ebenau JL, Verfaillie SCJ, van den Bosch KA, ..... Barkhof F et al
Grey zone amyloid burden affects memory function: the SCIENCe project
European Journal of Nuclear Medicine and Molecular Imaging 04 Sep 2020
https://doi.org/10.1007/s00259-020-05012-5

de Leeuw FA, Karamujić-Čomić H, Tijms BM,..... Barkhof F, Teunissen CE, van Duijn CM, van der Flier WM
Circulating metabolites are associated with brain atrophy and white matter hyperintensities
Alzheimer's and Dementia 04 Sep 2020
https://doi.org/10.1002/alz.12180

Legdeur N, Tijms BM, Konijnenberg E...... Barkhof F et al
Associations of Brain Pathology Cognitive and Physical Markers With Age in Cognitively Normal Individuals Aged 60–102 Years
The Journals of Gerontology: Series A 01 Sep 2020
https://doi.org/10.1093/gerona/glz180

Quattrini G, Pievani M, Jovicich J, Aiello M, Bargalló N, Barkhof F, ..... PharmaCog Consortium
Amygdalar nuclei and hippocampal subfields on MRI: Test-retest reliability of automated volumetry across different MRI sites and vendors
NeuroImage 116932 01 Sep 2020
https://doi.org/10.1016/j.neuroimage.2020.116932

Ulugut Erkoyun H, Groot C, .....Barkhof F, Pijnenburg Y
A clinical-radiological framework of the right temporal variant of frontotemporal dementia
Brain 01 Sep 2020
https://doi.org/10.1093/brain/awaa225

Exalto LG, Boomsma JMF, Babapour Mofrad R, Barkhof F....... TRACE‐VCI study group
Sex differences in memory clinic patients with possible vascular cognitive impairment
Alzheimers Dement (Amst) 12(1):e12090 25 Aug 2020
https://doi.org/10.1002/dad2.12090

Bouman PM, Steenwijk MD, Pouwels PJW, Schoonheim MM, Barkhof F, Jonkman LE, Geurts JJG
Histopathology-validated recommendations for cortical lesion imaging in multiple sclerosis.
Brain 21 Aug 2020
https://doi.org/10.1093/brain/awaa233

Giovanni B. Frisoni, José Luis Molinuevo, Daniele Altomare, Emmanuel Carrera, Frederik Barkhof et al.
Precision prevention of Alzheimer's and other dementias: Anticipating future needs in the control of risk factors and implementation of disease-modifying therapies
Alzheimers Dement First published: 20 August 2020
https://doi.org/10.1002/alz.12132

Lisa Ann Gerdes, Claudia Janoschka, Maria Eveslage, .......Frederik Barkhof, Sven G. Meuth, Tania Kümpfel, Heinz Wiendl, Reinhard Hohlfeld, and Luisa Klotz
Immune signatures of prodromal multiple sclerosis in monozygotic twins.
Proc Natl Acad Sci U S A 17 Aug 2020
https://doi.org/10.1073/pnas.2003339117

Mofrad RB, Tijms BM, Scheltens P, Barkhof F, van der Flier WM, AM Sikkes S, Teunissen CE
Sex differences in CSF biomarkers vary by Alzheimer’s disease stage and APOE ε4 genotype
Neurology 10.1212/WNL.0000000000010629 11 Aug 2020
https://doi.org/10.1212/WNL.0000000000010629

Barbara J.H. Verhaar, Francisca A. de Leeuw, Astrid S. Doorduijn, Jay L.P. Fieldhouse, Ondine van de Rest, Charlotte E. Teunissen, Bart N.M. van Berckel, Frederik Barkhof et al.
Nutritional status and structural brain changes in Alzheimer's disease: The NUDAD project.
Alzheimers Dement (Amst) 12(1):e12063 11 Aug 2020
https://doi.org/10.1002/dad2.12063

Boomsma JMF, Exalto LG, Barkhof F ........TRACE‐VCI study group
Prediction of poor clinical outcome in vascular cognitive impairment: TRACE-VCI study.
Alzheimers Dement (Amst) 12(1):e12077 10 Aug 2020
https://doi.org/10.1002/dad2.12077

Geraldes R, Juryńczyk M, Dos Passos GR, .........Chard D, Barkhof F, Gasperini C, Rovira A, DeLuca G, Palace J, MAGNIMS study group
The role of pontine lesion location in differentiating multiple sclerosis from vascular risk factor-related small vessel disease.
Mult Scler 1352458520943777 06 Aug 2020
https://doi.org/10.1177/1352458520943777

Alexander S, Peryer G, Gray E, Barkhof F, Chataway J
Wearable technologies to measure clinical outcomes in multiple sclerosis: A scoping review
Multiple Sclerosis Journal 1352458520946005 04 Aug 2020
https://doi.org/10.1177/1352458520946005

Goodkin O, Pemberton HG, Vos SB, Prados F, Das RK, Moggridge J, De Blasi B, Bartlett P, Williams E, Campion T, Haider L, Pearce K, Bargallό N, Sanchez E, Bisdas S, White M, Ourselin S, Winston GP, Duncan JS, Cardoso J, Thornton JS, Yousry TA, Barkhof F
Clinical evaluation of automated quantitative MRI reports for assessment of hippocampal sclerosis
Eur Radiol 04 Aug 2020
https://doi.org/10.1007/s00330-020-07075-2

Di Napoli A, Cheng SF, Gregson J, Atkinson D, Markus JE, Richards T, Brown MM, Sokolska M, Jäger HR
Arterial Spin Labeling MRI in Carotid Stenosis: Arterial Transit Artifacts May Predict Symptoms
Radiology 200225 13 Oct 2020
https://doi.org/10.1148/radiol.2020200225

Paterson RW, Brown RL, Benjamin L, .......Silber E, Schott JM, Chandratheva A, Perry RJ, Simister R, Checkley A, Longley N, Farmer SF, Carletti F, Houlihan C, Thom M, Lunn MP, Spillane J, Howard R, Vincent A, Werring DJ, Hoskote C, Jäger HR, Manji H, Zandi MS
The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings
Brain : a journal of neurology 143(10):3104-3120 01 Oct 2020
https://doi.org/10.1093/brain/awaa240

Russell LL, Greaves CV, Bocchetta M, Nicholas J, Convery RS, Moore K, …… Thomas DL, et al
Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort
Cortex 26 Sep 2020
https://doi.org/10.1016/j.cortex.2020.08.023

Shaikh F, Dupont-Roettger D, Dehmeshki J, Awan O, Kubassova O, Bisdas S
The Role of Imaging Biomarkers Derived From Advanced Imaging and Radiomics in the Management of Brain Tumors
Frontiers in Oncology 10:23 Sep 2020
https://doi.org/10.3389/fonc.2020.559946

Abdalla G, Dixon L, Sanverdi E, Machado PM, Kwong JSW, Panovska-Griffiths J, Rojas-Garcia A, Yoneoka D, Veraart J, Van Cauter S, Abdel-Khalek AM, Settein M, Yousry T, Bisdas S.  The diagnostic role of diffusional kurtosis imaging in glioma grading and differentiation of gliomas from other intra-axial brain tumours:  a systematic review with critical appraisal and meta-analysis.  Neuroradiology, online 4th May 2020
 
Alberich-Bavarri A, Sourbron S, Golay X, deSouza N, Smits M, van der Lugt A, Boellard R.  ESR Statement on the validation of imaging biomarkers.  Insights into Imaging 11(1):4 June 2020


Bargalló N, Cano-López I, Rosazza C, Vernooij MW, Smits M, Vitali P, Alvarez-Linera J, Urbach H, Mancini L, Ramos A, Yousry T. Clinical practice of language fMRI in epilepsy centers: a European survey and conclusions by the ESNR Epilepsy Working Group. Neuroradiology online 1st May 2020.

Biondetti E, Karsa A, Thomas D, Shmueli K.  Investigating the accuracy and precision of TE-dependent versus multi-echo QSM using Laplacian-based methods at 3T.  Magnetic Resonance in Medicine, online 3rd June 2020
 
Bisdas S, Schafer R, Kolb R, Bender B, Klose U.  Lactate as clinical tumour biomarker:  Optimization of lactate detection and quantification in MR spectroscopic imaging of glioblastomas.  European Journal of Radiology 109171, online July 2020


Bot JCJ, Mazzai L, Hagenbeek RE, Ingala S, van Oosten B, Sanchez-Aliaga E, Barkhof F. Brain military enhancement. Neuroradiology, online 10 January 2020.

Buchanan SM, Parker TD, Lane CA, Keshavan A,  Keuss SE, Lu K, James S-N, Murray-Smith H, Wong A, Nicholas J, Thomas DL, Sudre C, Fox NC, Richards M, Schott JM.   Olfactory testing does not predict beta-amyloid, MRI measures of neurodegeneration or vascular pathology in the British 1946 birth cohort.  Journal of Neurology, online 24 Jun 2020

Chataway J, De Angelis F, Connick P, Parker RA, Plantone D, Doshi A, John N, Stutters J, MacManus D, Prados Carrasco F, Barkhof F, Ourselin S, Braisher M, Ross M, Cranswick G, Pavitt SH, Giovannoni G, Gandini Wheeler-Kingshott CA, Hawkins C, Sharrack B, Bastow R, Weir CJ, Stallard N, Chandran S, MS-SMART Investigators. Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial. The Lance Neurology, online 22nd January 2020

Cole JH, Raffel J, Friede T, Eshaghi A, Brownlee WJ, Chard D, De Stefano N, Enzinger C, Pirpamer L, Filippi M, Gasperini C, Rocca MA, Rovira A, Ruggieri S, Sastre-Garriga J, Stromillo ML, Uitdehaag B, Vrenken H, Barkhof F, Nicholas R, Ciccarelli O, MAGNIMS study group.  Longitudinal assessment of multiple sclerosis with the brain-age paradigm.  Annals of Neurology, online 14th April 2020

Cortese R, Tur C Prados F, Schneider T, Kanber B, Moccia M, Wheeler-Kingshott CAG, Thompson AJ, Barkhof F, Ciccarelli O. Ongoing microstructural changes in the cervical cord underpin disability progression in early primary progressive multiple sclerosis. Multiple Sclerosis Journal, online 21st January 2020.

De Angelis F, Connick P, Parker RA, Plantone D, Doshi A, John N Stutters J, MacManus D, Prados F, Marshall I, Solanky B, Samson RS, Barkhof F, Ourselin S,  Braisher M, Ross M, Cranswick G, Pavitt SH, Gnanapavan S, Giovannoni G, Wheeler-Kingshot CAMG, Hawkins C, Sharrack B, Bastow R, Weir CJ, Stallard N, Chandran S, Chataway J.  Amiloride, fluoxetine or riluzole to reduce brain volume loss in secondary progressive multiple sclerosis: the MS-SMART four-arm RCT.  Efficacy and Mechanism Evaluation 7(3):1-72, May 2020

D’Arco F, Youssef A, Ioannidou E, Bisdas S, Pinelli L, Caro-Dominguez P, Nash R, Siddiqui A, Talenti G. Temporal bone and intracranial abnormalities in syndromic causes of hearing loss: an updated guide. European Journal of Radiology 2020; 123(17):108803.

De Sitter A, Visser M, Brouwer I, Cover KS, van Schijndel RA, Eijgelaar RS, Muller DMJ, Ropele S, Kappos L, Rovira A, Filippi M, Enzinger C, Frederiksen J, Ciccarelli O, Guttmann CRG, Wattjes MP, Witte MG, de Witt Hamer PC, Barkhof F, Vrenken H, on behalf of the MAGNIMS Study Group and Alzheimer’s Disease Neuroimaging Initiative. Facing privacy in neuroimaging: removing facial features degrades performance of image analysis methods. European Radiology, online 1st February 2020.

De Sitter A, Verhoeven T, Burggraaff J, Liu Y, Simoes J, Ruggieri S, Palotai M, Brouwer I, Versteeg A, Wottschel V, Ropele S, Rocca MA, Gasperini C, Gallo A, Yiannakas MC, Rovira A, Enzinger C, Filippi M, De Stefano N, Kappos L, Frederiksen JL, Uitdehaag BMJ, Barkhof F, Guttmann CRG, Vrenken H, MAGNIMS Study Group. Reduced accuracy of MRI deep grey matter segmentation in multiple sclerosis:  an evaluation of four automated methods against manual reference segmentations in a multi-center cohort.  J Neurol, 3rd July 2020

Desai RA, Davies AL, Del Rossi N, Tachrount M, Dyson A, Gustavson B, Kaynezhad P, Mackenzie L, van der Putten MA, McElroy D, Schiza D, Linington C, Singer M, Harvey AR, Tachtsidis I, Golay X, Smith KJ.  Nimodipine reduces dysfunction and demyelination in models of multiple sclerosis.  Annals of Neurology, online 15th April 2020
 
Dicks E, van der Flier WM, Scheltens P, Barkhof F, Tijms BM.  Single-subject gray matter networks predict future cortical atrophy in preclinical Alzheimer's disease.  Neurobiology of Aging 94:71-80, 1st October 2020
 
Ebenau JL, Timmers T, Wesselman LMP, Verberk IMW, Verfaillie SCJ, Slot RER, van Harten AC, Teunissen CE, Barkhof F, van den Bosch KA, van Leeuwenstijn M, Tomassen J, Braber AD, Visser PJ, Prins ND, Sikkes SAM, Scheltens P, van Berckel BNM, van der Flier WM.  ATN classification and clinical progression in subjective cognitive decline.  Neurology, online 10th June 2020


Evans PG, Sokolska M, Alves A, Harrison IF,  Ohene Y, Nahavandi P, Ismail O, Miranda E, Lythgoe MF, Thomas DL, Wells JA.  Non-invasive MRI of blood-cerebrospinal fluid barrier function.  Nature Communications 11(1):2081, 29th April 2020

Geraldes R, Juryńczyk M, Dos Passos G, Prichler A, Chung K, Hagens M, Ruggieri S, Huerga E, Sastre-Garriga J, Enzinger C, Chard DT, Barkhof F, Gasperini C, Rovira A, Deluca GC, Palace J. Distinct influence of different vascular risk factors on white matter brain lesions in multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, online 1st April 2020.


Golay X, Demetriou E, Kujawa A.  Pulse sequences for measuring exchange rates between proton species: from unlocalised NMR spectroscopy to chemical exchange saturation transfer imaging.  Progress in Nuclear Magnetic Resonance Spectroscopy, online 10th August 2020
 
Gratwicke J, Zrinzo L, Kahan J, Peters A, Brechany U, McNichol A, Beigi M, Akram H, Hyam J, Oswal A, Day B, Mancini L, Thornton J, Yousry T, Crutch SJ, Taylor J-P, McKeith I, Rochester L, Schott JM, Limousin P, Burn D, Rossor MN, Hariz M, Jahanshahi M, Foltynie T.  Bilateral Nucleus Basalis of Meynert Deep Brain Stimulation for dementia with Lewy bodies.  A randomised clinical trial. Brain Stimulation, online 22nd April 2020 

Hawsawi HB, Papadaki A, Thornton JS, Carmichael DW, Lemieux L.  Temperature measurements in the vicinity of human intracranial EEG electrodes exposed to body-coil RF for MRI at 1.5T.  Frontiers in Neuroscience 14; 12 May 2020

Heller C, Foiani MS, Moore K, Convery R, Bocchetta M, Neason M, Cash DM, Thomas D et al. Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia. Journal of Neurology, Neurosurgery and Psychiatry, online 14th January 2020.

Kim M, Kuiawa A, Battiston M, Demetriou E, Schneider T, Collorone S, Tur C, Evans V, Okuchi S, Atkinson D, Wheeler-Kingshott C, Golay X. Translating pH-sensitive PROgressive saturation for Quantifying Exchange using Saturation Times (PRO-QUEST) MRI to a 3T clinical scanner. Magnetic Resonance in Medicine, online 4th February 2020.

Leeuwis AE, Hooghiemstra AM, Bron EE, Kuipers S, Oudeman EA, Kalay T, Brunner-La Rocca HP, Kappelle LJ, van Oostenbrugge RJ, Greving JP, Niessen WJ, van Buchem MA, van Osch MJP, van Rossum AC, Prins ND, Biessels GJ, Barkhof F, van der Flier WM.  Cerebral blood flow and cognitive functioning in patients with disorders along the heart-brain axis:  Cerebral blood flow and the heart-brain axis. Alzheimer’s and Dementia: Translational Research and Clinical Interventions, online 12th May 2020

Leijenaar JF, Groeneveld GJ, Klaasen ES, Leeuwis AE, Scheltens P, Weinstein HC, van Gerven JMA, Barkhof F, van der Flier WM, Prins ND. Methylphenidate and galantamine in patients with vascular cognitive impairment – the proof-of-principle study STREAM-VCI. Alzheimer’s Res Ther 2020; 12(1):10.

Lingam I, Avdic-Belltheus A, Meehan C, Martinello K, Ragab S, Peebles D, Barkhuizen M, Tann CJ, Tachtsidis I, Wolfs TGAM, Hagberg H, Klein N, Fleiss B, Gressens P, Golay X, Kramer BW, Robertson JN.  Serial blood cytokine and chemokine mRNA and microRNA over 48 h are insult specific in a piglet model of inflammation-sensitized hypoxia-ischaemia.  Pediatr Research, online 10th June 2020

Lopes Alves I, Collij LE, Altomare D, Frisoni GB, Saint-Aubert L, Payoux P, Kivipelto M, Jessen F, Drzezga A, Leeuwis A, Wink AM, Visser PJ, van Berckel BNM, Scheltens P, Gray KR, Wolz R, Stephens A, Gismondi R, Buckely C, Gispert JD, Schmidt M, Ford L, Ritchie C, Farrar G, Barkhof F, Molinuevo JL, AMYPAD Consortium.  Quantitative amyloid PET in Alzheimer's disease: the AMYPAD prognostic and natural history study.  Alzheimers Dement, online 12th April 2020

Marizzoni M, Ferrari C, Babiloni C, Albani D, Barkhof F, Cavaliere L, Didic M, Forloni G, Fusco F, Galluzzi S, Hensch T, Jovicich J, Marra C, Molinuevo JL, Nobili F, Parnetti L, Payoux P, Ranjeva JP, Ribaldi F, Rolandi E, Rossini PM, Salvatore M, Soricelli A, Tsolaki M, Visser PJ, Wiltfang J, Richardson JC, Bordet R, Blin O, Frisoni GB. CSF cutoffs for MCI due to AD depend on APOEe4 carrier status. Neurobiology of Aging, online 1st January 2020 and 1st May 2020.

Maynard J, Okuchi S, Wastling S, Busaidi AA, Almossawi O, Mbatha W, Brandner S, Jaunmuktane Z, Koc AM, Mancini L, Jager R, Thust S.  World Health Organization Grade II/III Glioma Molecular Status: Prediction by MRI morphologic features and apparent diffusion coefficient.  Radiology 191832, online 21st April 2020

Moore K, Convery R, Bocchetta M, Neason M, Cash DM, Greaves C, Russell LL, Clarke MTM, Peakman G, van Swieten J, Jiskoot L, Moreno F, Barandiaran M, Sanchez-Valle R, Borroni B, Laforce R, Doré M-C, Masellis M, Tartaglia MC, Graff C, Galimberti D, Rowe JB, Finger E, Synofzik M, Karnath H-O, Vandenberghe R, de Mendonça A, Maruta C, Tagliavini F, Santana I, Ducharme S, Butler C, Gerhard A, Levin J, Danek A, Otto M, Warren JD, Rohrer JD, Genetic FTD Initiative, GENFI. A modified Camel and Cactus Test detects presymptomatic semantic impairment in genetic frontotemporal dementia within the GENFI cohort. Appl Neuropsychol Adult, online 5th February 2020.

Muller DMJ, Robe PA, Ardon H, Barkhof F, Bello L, Berger MS, Bouwknegt W, Van den Brink WA, Conti Nibali M, Eijgelaar RS, Furtner J, Han SJ, Hervey-Jumper SL, Idema AJS, Kiesel B, Kloet A, De Munck JC, Rossi M, Sciortino T, Vandertop WP, Visser M, Wagemakers M, Widhalm G, Witte MG, Zwinderman AH, De Witt Hamer PC.  Quantifying eloquent locations for glioblastoma surgery using resection probability maps.  J Neurosurg, online 3rd April 2020
  
Mutsaerts HJMM, Petr J, Groot P, Vandemaele P, Ingala S, Robertson AD, Baclavu L, Groote I, Kuijf H, Zelaya F, O’Daly O, Hilal S, Wink AM, Kant I, Caan MWA, Morgan C, de Bresser J, Lysvik E, Schrantee A, Bjornebekk A, Clement P, Shirzadi Z, Kuijer JPA, Wottschel V, Anazodo UC, Pajkrt D, Richard E, Bokkers RPH, Reneman L, Masellis M, Gunther M, MacIntosh BJ, Achten E, Chappell MA, van Osch MJP, Golay X, Thomas DL, de Vita E, Bjornerud A, Nederveen A, Hendrikse J, Asllani I, Barkhof F.  ExploreASL:  an image processing pipeline for multi-center ASL perfusion MRI studies.  NeuroImage 117031, online Oct 2020


Okuchi S, Hammam A, Golay X, Kim M, Thust S. Endogenous chemical exchange saturation transfer (CEST) MR imaging for the diagnosis and therapy response assessment of brain tumors: A systematic review. Radiology: Imaging Cancer, online 31st January 2020.

Oudega ML, Siddiqui A, Wattjes MP, Barkhof F, ten Kate M, Muller M, Bouckaert F, Vandenbulcke M, De Winter F-L, Sienaert P, Stek ML, Comijs HC, Korten NCM, Emsell L, Eikelenboom P, Rhebergen D, van Exel E, Dols A. Are apathy and depressive symptoms related to vascular white matter hyperintensities in severe late life depression? Journal of Geriatric Psychiatry and Neurology, online 10th February 2020.

Parker TD, Cash DM, Lane CA, Lu K, Malone IB, Nicholas JM, James S, Keshavan A, Murray-Smith H, Wong A, Buchanan SM, Keuss SE, Sudre CH, Thomas DL, Crutch SJ, Fox NC, Richards M, Schott JM.  Amyloid B influences the relationship between cortical thickness and vascular load.  Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring 12(1):17 April 2020
 
Patodia S, Tachrount M, Somani A, Scheffer I, Yousry T, Golay X, Sisodiya S, Thom M.  MRI and pathology correlations in the medulla in SUDEP: A post-mortem study.  Neuropathol Appl Neurobiol, online 19th June 2020
 
Pitkanen J, Koikkalainen J, Nieminen T, Marinkovic I, Curtze S, Sibolt G, Jokinen H, Rueckert D, Barkhof F, Schmidt R, Pantoni L, Scheltens P, Wahlund L-O, Korvenoja A, Lotjonen J, Erkinjuntti T, Melkas S.  Evaluating severity of white matter lesions from computed tomography images with convolutional neural network.  Neuroradiology, online 13th April 2020


Prados F, Moccia M, Johnson A, Yiannakos M, Grussu F, Cardoso MJ, Ciccarelli O, Ourselin S, Barkhof F, Wheeler-Kinghott C. Generalised boundary shift integral for longitudinal assessment of spinal cord atrophy. NeuroImage 2020; 209, online 1st April 2020.

Quattrini G, Pievani M, Jovicich J, Aiello M, Bargallo N, Barkhof F, Bartres-Faz D, Beltramello A, Pizzini FB, Blin O, Bordet R, Caulo M, Constantinides M, Didic M, Drevelegas A, Ferretti A, Fiedler U, Floridi P, Gros-Dagnac H, Hensch T, Hoffmann K-T, Kuijer JP, Lopes R, Marra C, Muller BW, Nobili F, Parnetti L, Payoux P, Picco A, Ranjeva J-P, Roccatagliata L, Rossini PM, Salvatore M, Schonknecht P, Schott BH, Sein J, Soricelli A, Tarducci R, Tsolaki M, Visser PJ, Wiltfang J, Richardson JC, Frisoni GB, Marizzoni M, PharmaCog Consortium.  Amygdalar nuclei and hippocampal subfields on MRI:  Test-retest reliability of automated volumetry across different MRI sites and vendors.  NeuroImage 116932, 1st September 2020

Rhodius-Meester HFM, van Maurik IS, Koikkalainen J, Tolonen A, Frederiksen KS, Hasselbalch SG, Soininen H, Herukka SK, Remes AM, Teunissen CE, Barkhof F, Pijnenburg YAL, Scheltens P, Lötjönen J, van der Flier WM. Selection of memory clinic patients for CSF biomarker assessment can be restricted to a quarter of cases by using computerized decision support, without compromising diagnostic accuracy. PloS One 2020; 15(1):e0226784.


Robertson NJ, Lingam I, Meehan C, Martinello KA, Avdic-Belltheus A, Stein L, Tachrount M, Price D, Sokolska M, Bainbridge A, Hristova M, Fleiss B, Kramer BW, Gressens P, Golay X. High-dose melatonin and ethanol excipient combined with therapeutic hypothermia in a newborn piglet asphyxia model. Scientific Reports 2020; 10(1):3898.


Romeo V, Stanzione A, Gaudieri V, Nappi C, Cuocolo R, Maurea S, Cuocolo A, Brunetti A, Bisdas S.  A critical appraisal of the quality of F-18-FDG PET/CT guidelines in oncology using the AGREE II tool:  A EuroAIM initiative. European Journal of Radiology 126: 108930, 1st May 2020

Sastre-Garriga J, Pareto D, Battaglini M, Rocca MA, Ciccarelli O, Enzinger C, Wuerfel J, Sormani MP, Barkhof F, Yousry TA et al. MAGNIMS consensus recommendations on the use of brain and spinal cord atrophy measures in clinical practice. Nature Reviews Neurology, online 1st March 2020.

Solanky BS, Prados F, Tur C, Yiannakas MC, Kanber B, Cawley N, Brownlee W, Ourselin S, Golay X, Ciccarelli O, Gandini Wheeler-Kingshott CAM.  Sodium in the relapsing-remitting multiple sclerosis spinal cord:  increased concentrations and associations with microstructural tissue anisotropy.  Journal of Magnetic Resonance Imaging, online 1st June 2020
 
Sudre CH, Panovska-Griffiths J, Sanverdi E, Brandner S, Katsaros VK, Stranjalis G, Pizzini FB, Ghimenton C, Surlan-Popovic K, Avsenik J, Spampinato MV, Nigro M, Chatterjee AR, Attye A, Grand S, Krainik A, Anzalone N, Conte GM, Romeo V, Ugga L, Elefante A, Ciceri EF, Guadagno E, Kapsalaki E, Roettger D, Gonzalez J, Boutelier T, Cardoso MJ, Bisdas S.  Machine learning assisted DSC-MRI radiomics as a tool for glioma classification by grade and mutation status. BMC Med Inform Decision Making 20(1):149 6th July 2020


Van de Beek M, van Steenoven J, van der Zande JJ, Barkhof F, Teunissen CE, ban der Flier WM, Lemstra AW. Prodromal dementia with Lewy bodies: Clinical characterization and predictors of progression. Movement Disorders, online 11th February 2020.

Van Faals NL, Dekker I, Balk LI, Moraal B, Barkhof F, Uitdehaag BMJ, Killestein J, Wattjes MP.  Clinico-radiological dissociation of disease activity in MS patients:  frequency and clinical relevance.  Journal of Neurology, online 20th June 2020

Westwood S, Baird Al, Anand SN, Nevado-Holgado AJ, Kormilitzin A, Shi L, Hye A, Ashton NJ, Morgan AR, Bos I, Vos SJB, Baker S, Buckley NJ, Ten Kate M, Scheltens P, Teunissen CE, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC< Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lléo A, Sala I, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Freund-Levi Y, Frölich L, Dobricic V, Legido-Quigley C, Bertram L, Barkhof F, Zetterberg H, Morgan BP, Streffer J, Bisser PJ, Lovestone S. Validation of plasma proteomic biomarkers relating to brain amyloid burden in the EMIF-Alzheimer’s Disease Multimodal Biomarker Discovery Cohort. J Alzheimer’s Disease, online 22nd January 2020.

2018

Robertson NJ, Martinello K, Lingam I, Avdic-Belltheus A, Meehan C, Alonso-Alconada D, Ragab S, Bainbridge A, Sokolska M, Tachrount M, Golay X, et al. Melatonin as an adjunct to therapeutic hypothermia in a piglet model of neonatal encephalopathy: a translational study. Neurobiology of Disease, 2018, in press UCL Discovery

Zhu Y, Ramasawmy R, Johnson SP, Taylor V, Gibb A, Pedley RB, Chattopadhyay N, Lythgoe M, Golay X, Bradley D et al. Non-invasive imaging of disrupted protein homeostasis induced by proteasome inhibitor treatment using chemical exchange saturation transfer MRI. Scientific Reports, online 2 November 2018.

Mitra S, Kendall G, Bainbridge A, Sokolska M, Dinan M, Uria-Avellanal C, Price D, McKinnon K, Gunny R, Huertas-Ceballos A et al. Proton Magnetic Resonance Spectroscopy lactate/N-Acetylaspartate within two weeks of birth accurately predicts 2-year motor, cognitive and language outcomes in neonatal encephalopathy after therapeutic hypothermia. Archives of Disease in Childhood: Fetal and Neonatal, 2018 in press UCL Discovery

Selby NM, Blankestijn PJ, Boor P, Combe C, Eckardt K-U, Eikefjord E, Garcia-Fernandez N, Golay X, Gordon I, Grenier N, et al. Magnetic resonance imaging biomarkers for chronic kidney disease: a position paper from the European Cooperation in Science and Technology Action PARENCHIMA. Nephrol Dial Transplant 2018; 33 (suppl 2) ii4-ii14 UCL Discovery

Haddow LJ, Godi C, Sokolska M, Cardoso MJ, Oliver R, Winston A, Stohr W, Clarke A, Chen F, Williams IG et al. Brain perfusion, regional volumes and cognitive function in HIV positive patients treated with protease inhibitor monotherapy. Clin Infect Dis,2018, in press UCL Discovery

Golay XGGR, da Silva NA, Lohmann P, Fairney J, Magill AW, Oros Peusquens A-M, Choi C-H, Stirnberg R, Stoffels G, Galldiks N et al. Hybrid MR-PET of brain tumours using amino acid PET and chemical exchange saturation transfer MRI. European Journal of Nuclear Medicine and Molecular Imaging, 2018; 45(6):1031-1040 UCL Discovery

Rocca MA, Barkhof F, De Luca J, Frisen J et al, the MAGNIMS study group. The hippocampus in multiple sclerosis. Lancet Neurology 2018; 17(10):918-926.

Morrow JM, Evans MRB, Grider T, Sinclair CDJ, Thedens D, Shah S, Yousry TA, Hanna MG, Nopoulos P, Thornton JS et al. Validation of MRC Centre MRI calf muscle fat fraction protocol as an outcome measure in CMT1A. Neurology 2018 in press UCL Discovery

Thust S, Heiland S, Falini A, Jager R, Waldman AD, Sundgren PC, Godi C, Katsaros VK, Ramos A, Bargallo N et al. Glioma imaging in Europe: A survey of 220 centres and recommendations for best clinical practice. European Radiology 2018; 28(8):3306-3317 UCL Discovery

Major EO, Yousry TA, Clifford DB. Pathogenesis of progressive multifocal leukoencephalopathy and risks associated with treatments for multiple sclerosis: a decade of lessons learned. Lancet Neurology 2018; 17(7):578

Bugiardini E, Morrow JM, Shah S, Woods CL, Lynch DS, Pitmann AM, Reilly MM, Houlden H, Matthews E, Parton M Yousry T, et al. The diagnostic value of MRI pattern recognition in distal myopathies. Frontiers in Neurology 2018; 9-11 UCL Discovery

Scott CJ, Jiao J, Melbourne A, Burgos N, Cash DM, De Vita E, Markiewicz PJ, O'Connor A, Thomas DL, Weston PS et al. Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL-MRI: proof of concept. Journal of Cerebral Blood Flow and Metabolism 2018, in press UCL Discovery

Harrison IF, Diow B, Akilo AB, Evans PG, Ismail O, Ohene Y, Nahavandi P, Thomas DL, Lythgoe MF, Wells JA. Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with DTI MIRI. ELife 2018; 7:31 UCL Discovery

Barkhof F, Thomas DL. Mapping deep gray matter iron in multiple sclerosis by using quantitative magnetic susceptibility. Radiology 2018 in press UCL Discovery

Bisdas S, Shen H, Thust S, Katsaros V, Stranjalis G, Boskos C, Brandner S, Zhang J. Texture analysis- and support vector machine-assisted diffusional kurtosis imaging may allow in vivo gliomas grading and IDH-mutation status prediction: a preliminary study. Scientific Reports 2018; 8(1):6108.

Bishop CA, Ricotti V, Sinclair CDJ, Evans MRB, Butler JW, Morrow JM, Hanna MG, Matthews PM, Yousry TA, Muntoni F, John Thornton et al. Semi-automated analysis of diaphragmatic motion with dynamic magnetic resonance imaging in healthy controls and non-ambulant subjects with Duchenne Muscular Dystrophy. Frontiers in Neurology 2018; 9:26.

Boers AMM, Jansen IGH, Beenen LFM …Brown MM …Majoie CBLM. Association of follow-up infarct volume with functional outcome in acute ischemic stroke: a pooled analysis of seven randomized trials. Journal of Neurointerventional Surgery, online 7 April 2018.

Ciccarelli O, De Stefano N, Giorgio A …. Yousry T…Rovira A. Radiologically isolated syndrome or subclinical multiple sclerosis: MAGNIMS Consensus recommendations. Multiple Sclerosis Journal, online 1 February 2018.

Demetriou E, Tachrount M, Zaiss M, Shmueli K, Golay X. PRO-QUEST: a rapid assessment method based on progressive saturation for quantifying exchange rates using saturation times in CEST. Magnetic Resonance in Medicine, online 5 March 2018.

Geraldes R, Ciccarelli O, Barkhof F, De Stefano N….Yousry T …MAGNIMS study group. The current role of MRI in differentiating multiple sclerosis from its imaging mimics. Nature Reviews Neurology 2018; 14(4):213.

Golay XGGR, Riemer F, Solanky BS, Wheeler-Kingshott CAM. Bi-exponential 23NaT2* components analysis in the human brain. NMR in Biomedicine, online 26 Feb 2018.

Golay XGGR, da Silva NA, Lohmann P, Fairney J, Magill AW et al. Hybrid MR-PET of brain tumours using amino acid PET and chemical exchange saturation transfer MRI. European Journal of Nuclear Medicine and Molecular Imaging, online 16 April 2018.

Haller S, Vernooij MW, Kuijer JPA, Larsson E-M, Jäger HR, Barkhof F. Cerebral microbleeds: imaging and clinical significance. Radiology 2018; 287(1):11-28.

Kehoe PG, Blair PS, Howden B, Thomas DL …. Ben-Shlomo Y. The rationale and design of the reducing pathology in Alzheimer’s Disease through Angiotensin TaRgeting (RADAR) Trial
Journal of Alzheimer’s Disease, online 19 December 2018.

Major EO, Yousry TA, Clifford DB. Pathogenesis of progressive multifocal leukoencephalopathy and risks associated with treatments for multiple sclerosis: a decade of lessons learned. Lancet Neurology 2018; 17(5):467-480.

Miller DH, Lublin FD, Sormani MP …Yaldizli O, Macmanus DG, Yousry TA, …Wolinsky JS. Brain atrophy and disability worsening in primary progressive MS: Insights from the INFORMS study. Annals of Clinical and Translational Neurology, online 30 January 2018.

Muto M, Frauenfelder G, Senese R, Zeccolini F, Schena E, Giurazza F, Jäger HR. Dynamic susceptibility contrast (DSC) perfusion MRI in differential diagnosis between radionecrosis and neoangiogenesis in cerebral metastases using rCBV, rCBF and K2. La Radiologia Medica, online 5th March 2018.

Nery F, Gordon I, Thomas DL. Non-invasive renal perfusion imaging using arterial spin labelling MRI: challenges and opportunities. Diagnostics 2018; 8(1).

Parker TD, Slattery CF, Zhang J ….Thomas DL, Modat M, Cash DM, Crutch SJ, Alexander DC, Ourselin S, Fox NC, Zhang H, Schott JM. Cortical microstructure in young onset Alzheimer’s disease using neurite orientation dispersion and density imaging. Human Brain Mapping, online 25th March 2018.

Phyu P, Merwick A, Davagnanam I, Bolsover F, Jichi F, Wheeler-Kingshott C, Golay X, Hughes D, Cipolotti L, Murphy E, Lachmann RH, Werring DJ. Increased resting cerebral blood flow in adult Fabry disease: MRI arterial spin labelling study. Neurology 2018; 90(16):e1379-1385.

Pichat J, Iglesias JE, Yousry T, Ourselin S, Modat M. A survey of methods for 3D histology reconstruction. Medical Image Analysis 2018; 46:73-105.

Saba L, Yuan C, Hatsukami TS, Balu N… Jäger R et al. Carotid artery wall imaging: perspective and guidelines from the ASNR vessel wall imaging study group and expert consensus recommendations of the American Society of Neuroradiology. American Journal of Neuroradiology 2018; 39(2):E9-E31.

Schmierer K, McDowell A, Petrova N, Carassiti D, Thomas DL, Miquel ME. Quantifying multiple sclerosis pathology in post-morten spinal cord using MRI. NeuroImage, online 31st January 2018.

Thust SC, Hassanein S, Bisdas S, Rees JH, Hyare H, Maynard JA, Brandner S, Tur C, Jäger HR, Yousry TA, et al. Apparent diffusion coefficient for molecular subtyping of non-gadolinium-enhancing WHO grade II/III glioma: volumetric segmentation versus two-dimensional region of interest analysis. European Radiology online 23 March 2018.

Thust S, Heiland S, Falini A, Jäger R, Waldman AD, ….Vernooij MW, Yousry T et al. Glioma imaging in Europe: A survey of 220 centres and recommendations for best clinical practice. European Radiology, online 2nd March 2018, embargoed until 3rd Sept 2018.

Leeuwia A, Smith L, Melbourne A, Hughes A, Richards M, Prins N, Sokolska MJ, Atkinson D, Tillin T, Jager R et al. Cerebral blood flow and cognitive functioning in a community-based, multi-ethnic cohort: The SABRE study. Frontiers in Aging Neuroscience 2018; 10: article 279.

2017

Cortese R, Magnollay L, Tur Gomez C, Abdel-Aziz K, Jacob A, De Angelis F, Yiannakas MC, Prados Carrasco F, Ourselin S, Yousry T et al.  The value of the central vein sign at 3T to differentiate MS from seropositive-NMOSD.  Neurology, online 31 December 2017.

Al-Hajri A, Al-Mughairi S, Somani A, An S, Liu J, Miserocchi A, McEvoy AW, Yousry T, Hoskote C, Thom M.  Pathology-MRI correlations in diffuse low-grade epilepsy associated tumors.  Journal of  Neuropathology and Experimental Neurology 2017; 76(12):1023-1033. DOI: 10.1093/jnen/nlx090

Sudre CH, Anson BG, Davagnanam I, Schmitt A, Mendelson AF, Prados F, Smith L, Atkinson D, Hughes AD, Chaturvedi N et al.   Bullseye's representation of cerebral white matter hyperintensities.  Journal of  Neuroradiology, online 11 November 2017. DOI:  10.1016/j.neurad.2017.10.001

Fox TA, Jager R, Ardeshna KM. Cerebrospinal fluid leak after bone marrow biopsy.  British Journal of Haematology.  Online 19 October 2017.  DOI:  10.1111/bjh.14963

Breitkopf M, Bisdas S, Liebsch M, Behling F, Bender B, Tatagiba M, Roder C.  Safety, utility and clinical results of continuous intraoperative electrophysiologic monitoring in 1.5T iMRI-guided surgery.  World Neurosurgery 2017; 106:198-205. DOI: 10.1016/j.wneu.2017.06.054

Akram H, Wu C, Hyam J, Foltynie T, Limousin P, De Vita E, Yousry T, Jahanshahi M, Hariz M, Behrens T et al. L-Dopa responsiveness is associated with distinctive connectivity patterns in advanced Parkinson’s Disease. Movement Disorders 2017; 32(6):874-883 doi: 10.1002/mds.27017. Epub 2017 May 8.

Skardelly M, Dangel E, Gohde J, Noell S, Behling F, Lepski G, Borchers C, Koch M, Schittenhelm J, Bisdas S, Naumann A, Paulsen F, Zips D, von Hehn U, Ritz R, Tatagiba MS, Tabatabai G. Prolonged Temozolomide maintenance therapy in newly diagnosed glioblastoma. Oncologist, online 30 March 2017 doi: 10.1634/theoncologist.2016-0347. Epub 2017 Mar 30.

Gold R, Arnold DL, Bar-Or A, Hutchinson M, Kappos L, Havrdova E, MacManus DG, Yousry TA et al. Long-term effects of delayed-release dimethyl fumarate in multiple sclerosis: Interim analysis of ENDORSE, a randomized extension study. Multiple Sclerosis Journal 2017 Feb;23(2):253-265 doi: 10.1177/1352458516649037. Epub 2016 Jul 11.

Mok T, Jaunmuktane Z, Joiner S, Campbell T, Morgan C, Wakerley B, Golestani F, Rudge P, Mead S, Jäger HR, Wadsworth JD, Brandner S, Collinge J. Variant Creutzfeldt-Jakob Disease in a Patient with Heterozygosity at PRNP Codon 129. N Engl J Med. 2017 Jan 19;376(3):292-294 doi: 10.1056/NEJMc1610003.

2016

Damjanovic D, Valsasina P, Rocca MA, Stromillo ML, Gallo A, Enzinger C, Hulst HE, Rovira A, Muhlert N, De Stefano N et al. Hippocampal and deep gray matter nuclei atrophy is relevant for explaining cognitive impairment in MS: A multicentre study. AJNR American Journal of Neuroradiology, 2017 Jan;38(1):18-24. doi: 10.3174/ajnr.A4952. Epub 2016 Sep 29.

Tentolouris-Piperas V, Ryan NS, Thomas DL, Kinnunen KM. Brain imaging evidence of early involvement of subcortical regions in familial and sporadic Alzheimer's disease. Brain Research 2017; 1655:23-32 doi: 10.1016/j.brainres.2016.11.011. Epub 2016 Nov 12.doi: 10.1016/j.ejpn.2016.06.001. Epub 2016 Jun 20.

Thornton JS. Technical challenges and safety of magnetic resonance imaging with in situ neuromodulation from spine to brain. Eur J Paediatr Neurol. 2017 Jan;21(1):232-241 doi: 10.1016/j.ejpn.2016.06.001. Epub 2016 Jun 20.

Zarkali A, Gorgoraptis N, Miller R, John L, Merve A, Thust S, Jager R, Kullmann D, Swayne O. CD8+ encephalitis: a severe but treatable HIV-related acute encephalopathy. Pract Neurol. 2017 Jan;17(1):42-46 doi: 10.1136/practneurol-2016-001483. Epub 2016 Nov 1.

Massey LA, Miranda MA, Al-Helli O, Parkes HG, Thornton JS, So PW, White MJ, Mancini L, Strand C, Holton J et al. 9.4 MR microscopy of the substantia nigra with pathological validation in controls and disease. NeuroImage: Clinical 2016: 13:154-163 eCollection 2017.

Desai RA, Davies AL, Tachrount M, Kasti M, Laulund F, Golay X, Smith KJ. Cause and prevention of demyelination in a model multiple sclerosis lesion. Annals of Neurology 2016; 79(4):591-604 doi: 10.1002/ana.24607. Epub 2016 Feb 22.

De Vita E, Ridgway GR, White MJ, Porter MC, Caine D, Rudge P, Collinge J, Yousry TA, Jager HR, Mead S, Thornton JS, Hyare H. Neuroanatomical correlates of prion disease progression - a 3T longitudinal voxel-based morphometry study. NeuroImage Clinical 2016 Nov 2;13:89-96. eCollection 2017

Further information

 * Tentolouris-Piperas et al (2017). Brain imaging evidence of early involvement of subcortical regions in familial and sporadic Alzheimer's disease. Brain Research Volume 1655, 15 January 2017, Pages 23-32. doi.org/10.1016/j.brainres.2016.11.011