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UCL Queen Square Institute of Neurology

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Our research group comprises Post-Doctoral Fellows, Lab Technicians, PhD Candidates and Visiting Students.

Principal Investigator

Brownstone 2019

Professor Rob Brownstone

Professor Brownstone’s research program is built around the philosophy that while motor system disease phenomenology can be defined in people (his clinical practice), mechanisms must be studied in animal models in order to develop better treatment strategies. To this end, his lab has developed preparations and methodologies to study neural circuits in the mouse brain stem and spinal cord and their role(s) in motor behaviours. The lab uses a variety of tools to study circuits: from the study of biophysical properties in reduced preparations to the study of animal behaviour in targeted knock-out mice. They have identified a number of key circuits, including neural circuits underlying hand grasp function.

Contact:
Professor Rob Brownstone

Post Doctoral Researchers

 

Dr Isabel Glover

UCL IRIS Profile

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Dr Isabel Glover

 

Dr Camille Lancelin

UCL IRIS Profile

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Dr Camille Lancelin
 

Dr Amanda Pocratsky

UCL IRIS Profile

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Dr Amanda Pocratsky
shabbir neural circuits for movement

Dr Ayisha Shabbir

UCL IRIS Profile

 

Contact
Dr Ayisha Shabbir
calvin smith neural circuits for movement

Dr Calvin Smith

UCL IRIS Profile

I completed my PhD in 2016 at the University of Leeds, where I developed a novel in-situ perfused preparation to study the influence of descending brain systems on spinal sensory-motor circuits. I was also involved in projects aimed at promoting functional recovery from severe spinal cord injury using combinatorial therapies. After my PhD, I completed a 1 year post-doctoral fellowship in Dr Samit Chakrabarty’s lab, also at the University of Leeds. Here, I was able to develop an in vivo technique for simultaneously assessing homonymous and heteronymous spinal reflexes and their modulation.

The focus of my investigations in the Brownstone lab is to understand the mechanisms by which the C bouton complex is able to modulate motoneuron firing and therefore muscle contraction force. I use genetic, electrophysiological (in vivo and in vitro), anatomical and behavioural techniques to study how motoneuron ion channels clustered opposite the C bouton synapse contribute to modulation of muscle force production. I am also interested in the plasticity of pre and postsynaptic components of the C bouton during exercise training and neurological disease/injury.

Contact
Dr Calvin Smith

 

Research Assistants and Lab Technicians

 

Pierre Klein

UCL IRIS Profile

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Pierre Klein, Research Assistant

rafaela_fernandez

Rafaela Fernandez de la Fuente

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Rafaela Fernandez de la Fuente, Lab Technician

 

Hrista Micheva

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Hrista Micheva, Research Assistant
 

Students

anna_website_pic

Anna Hands

My PhD project aims to help refine a novel experimental method to restore paralysed muscle function being developed in the Greensmith Lab at UCL. When transplanted into a peripheral nerve, embryoid bodies (EBs) containing embryonic stem cell (ESC)-derived motoneurons can form functional NMJs, enabling control of muscle contraction by electrical or optical stimulation of the graft. However, if purified motoneuron aggregates are used, functional NMJs do not form. Therefore, my hypothesis is that other cells within EBs are necessary ESC-derived motor neuron maturation and functioning. To investigate this, I generate co-cultures of pure populations of ESC-derived motoneurons, astrocytes and V3 interneurons in vitro and use immunofluorescent, electrophysiological and calcium imaging techniques to characterise the neural networks that form. My results will help optimise graft composition to improve the efficacy of graft innervation of the paralysed muscle.

Grant/Other Support: Wellcome Trust-funded PhD

From 2012 to 2015, I studied Natural Sciences at Homerton College, University of Cambridge. After graduating, I began a PhD in Neuroscience at UCL. During my undergraduate degree and the rotation phase of the PhD course, I was completed short projects studying peripheral nerve regeneration in Professor Simona Parrinello’s lab at Imperial College London, a novel axon guidance molecule in the Professor Roger Keynes’ lab at University of Cambridge, modes of Schwann cell migration in Professor Alison Lloyd’s Lab at UCL, and zebrafish hunting and startle behaviour in Dr Isaac Bianco’s Lab at UCL. Supervised by Professors Linda Greensmith and Rob Brownstone, my PhD project examines the role of astrocytes and V3 interneurons in motor neuron maturation and function in vitro. I am also a student Green Champion for the Department of Neuromuscular Diseases and a board member of PPL PWR, an organisation which promotes sustainable innovation in schools and at festivals.

Contact
Anna Hands, PhD Candidate

 

Donald Iain MacDonald

Contact
Donald MacDonald, PhD Candidate

 

 

Support Staff

Dr Nadine Simons-Weidenmaier, Senior Lab Technician. Tel: 02034484455
Alice Winters, PA to Prof Rob Brownstone. Tel: 02031089649

 

Brownstone Lab Alumni

Post-Doctoral Fellows supervised:

 

Year

Name

Current Position

2017-2018

Hiroshi Nakagawa

Assistant Professor, Osaka University

2015-2017

Kosmas Deligkaris

Research Computing Technician II, Okinawa Institute of Science and Technology

2014-2018

Jeremy Chopek

Assistant Professor, University of Manitoba

2013-2016

Nicolas Stifani

 

2012-2014

Xiaolu Sun

Research Associate, UCLA

2011-2012

Sabrina Tazerart

Post-doctoral fellow, Université de Montréal

2008-2016

Izabela Panek

Health Administration

2007-2013

Pratip Mitra

Associate Professor, University of Texas Rio Grande Valley

2007-2011

Frederic Bretzner

Associate Professor, University of Laval

2006-2013

Tuan Bui

Assistant Professor, University of Ottawa

2004-2006

Evgueni Blagovechtchenski

Senior Research Fellow, Higher School of Economics, Moscow

2003-2006

Gareth Miles

Professor, University of St. Andrews

2002-2008

Jennifer Wilson

 

2001-2003

Zongming Li

Research Associate, University of Alberta