Principle Investigator: Professor Rob Brownstone
Professor Brownstone’s research program is built around the philosophy that while motor system disease phenomenology can be defined in people (his clinical practice), mechanisms must be studied in animal models in order to develop better treatment strategies. To this end, his lab has developed preparations and methodologies to study neural circuits in the mouse brain stem and spinal cord and their role(s) in motor behaviours. The lab uses a variety of tools to study circuits: from the study of properties in reduced preparations to the study of animal behaviour in targeted knock-out mice. They have identified a number of key circuits, including neural circuits underlying hand grasp function.
The focus in the lab is to understand how motor circuits contribute to rehabilitation of movement in disease or injury. As movement is affected in many neurological conditions, Professor Brownstone’s research program has widespread impact for the development of new strategies to improve movement in people with neurological disorders.
Our research is funded by the Wellcome Trust.