Exploring the neural control of the lower urinary tract in health and disease, and researching non-surgical options for managing neurogenic bladder, bowel and sexual dysfunction
- Mrs Maheen Pakzad
- Ms Sohier Elneil
- Dr Anton Emmanuel
- Dr Catherine Dalton
- Dr Xavier Game
- Dr Giuseppi Preziosi
- Mrs Collette Haslam
- To evaluate the central neural correlates of lower urinary tract function and dysfunction in neurogenic and idiopathic bladder conditions using advanced MR imaging techniques
- To investigate novel treatments for the management of bladder problems in patients with neurological disease
- To explore the mechanisms of action of treatments for neurogenic bladder dysfunction, such as detrusor injections of botulinum toxin and tibial nerve stimulation
- To study bladder and sexual dysfunction across different progressive neurological disorders
- To understand the basis for lower urinary tract dysfunction in Parkinson’s Disease, including the mechanisms responsible for nocturia
- To explore novel treatment for the prevention of urinary tract infections in patients with neurological disease
- To explore the interface between functional urological disorders and psychological co-morbidities
- To identify physiological phenotypes of gut dysfunction and develop a targeted therapy
Funded Rsesearch Projects
- Exploring Melatonin for the management of nocturia in Parkinson’s Disease. Funded by Parkinson’s UK
- The central control of lower urinary tract functions in patients with neurogenic and idiopathic lower urinary tract dysfunction; Collaborative study with University of Zurich. Funded by Multiple Sclerosis Society, UCL-ZNZ Neurosciences Award
- The Neurological and Urological Symptoms Study- collaboration with University of Edinburgh
- Exploring the causes for non-surgical urinary retention
- Exploring the role of PTNS (percutaneous tibial nerve stimulation) for the management of overactive bladder symptoms in neurological patients
- Recent publications from Uroneurology
Hare N, Georgopoulos P, Philips KE, Johnson JE, Seary C, Panicker JN, Stevenson VL. Improvement in overactive bladder symptoms in patients using functional electrical stimulation of the common peroneal nerve for walking. Clinical Rehabilitation 2018; 32(10):1357-1362.
Panicker JN, Anding R, Arlandis S, Blok B, Dorrepaal C, Harding C, Marcelissen T, Rademakers K, Abrams P, Apostolidis A. Do we understand voiding dysfunction in women? Current understanding and future perspectives: ICI-RS 2017. Neurourology and Urodynamics 2018; 37:S75-S85.
Sakakibara R, Panicker J, Simeoni S, Uchiyama T, Yamamoto T, Tateno F, Kishi M, Aiba Y. Bladder dysfunction as the initial presentation of multiple system atrophy: a prospective cohort study. Clinical Autonomic Research, 2018, in press.
Andersson K-E, Fry C, Panicker J, Rademakers K. Which molecular targets do we need to focus on to improve lower urinary tract dysfunction? ICI-RS 2017. Neurourology and Urodynamics 2018; 37:S117-S126.
Tudor KI, Seth JH, Liechti MD, Ochulor J, Gonzales G, Haslam C, Fox Z, Pakzad M, Panicker JN. Outcomes following percutaneous tibial nerve stimulation (PTNS) treatment for neurogenic and idiopathic overactive bladder. Clinical Autonomic Research, online 3 August 2018.
Tornic J, Panicker JN. The management of lower urinary tract dysfunction in multiple sclerosis. Current Neurology and Neuroscience Reports 2018; 18(8) UCL Discovery
Tudor KI, Eames S, Haslam C, Chataway J, Liechti MD, Panicker JN. Identifying barriers to help-seeking for sexual dysfunction in multiple sclerosis. Journal of Neurology, online 19 Sept 2018.
Apostolidis A, Wagg A, Rahnam A’I MS, Panicker JN, Brijens D, von Gontard A. Is there “brain OAB” and how can we recognize it? International Consultation on Incontinence Research Society (ICI-RS) 2017. Neurourology and Urodynamics, online February 2018.
Panicker JN, Anding R, Arlandis S….. Apostolidis A. Do we understand urinary retention in women? Current understanding and future perspectives: ICI-RS 2017. Neurourology and Urodynamics, in press.
Sihra N, Malde S, Panicker J, ….Pakzad M. Does the appearance of the urethral pressure profile trace correlate with the sphincter EMG findings in women with voiding dysfunction? Neurourology and Urodynamics 2018; 37-2:751-757.
Lad M, Parkinson MH, Rai M, Pandolfo M, Bogdanova-Mihaylova P, Walsh RA, Murphy S, Emmanuel A, Panicker J, Giunti P. Urinary, bowel and sexual symptoms in a cohort of patients with Friedreich's ataxia. Orphanet Journal of Rare Diseases 2017; 12(1):158. DOI: 10.1186/s13023-017-0709-y
Panicker J, Pakzad M, Fowler C. Fowler’s Syndrome: A primary disorder of urethral sphincter relaxation. The Obstetrician and Gynaecologist, online 31 October 2017
Youssef NA, Schneider MP, Mordasini L, Ineichen BV, Bachmann LM, Chartier-Kastler E, Panicker JN, Kessler TM. Cannabinoids for treating neurogenic lower urinary tract dysfunction in patients with multiple sclerosis: a systematic review and meta-analysis. BJU International 2017; 119(4):515-521doi: 10.1111/bju.13759. Epub 2017 Feb 23.
Batla A, Tayim N, Pakzad M, Panicker JN. Treatment Options for Urogenital Dysfunction in Parkinson's Disease. Curr Treat Options Neurol. 2016 Oct;18(10):45. doi: 10.1007/s11940-016-0427-0.
Phé V, Pakzad M, Haslam C, Gonzales G, Curtis C, Porter B, Chataway J, Panicker JN. Open label feasibility study evaluating D-mannose combined with home-based monitoring of suspected urinary tract infections in patients with multiple sclerosis. Neurourol Urodyn. 2017 Sep;36(7):1770-1775. doi: 10.1002/nau.23173. Epub 2016 Nov 4.
Tudor KI, Sakakibara R, Panicker JN. Neurogenic lower urinary tract dysfunction: evaluation and management. J Neurol. 2016 Dec; 263(12):2555-2564.doi:10.1007/s00415-016-8212-2
- Clinical services
- Academic enquiries
- Study at Institute of Neurology
* Sihra N, Malde S, Panicker J et al. Does the appearance of the urethral pressure profile trace correlate with the sphincter EMG findings in women with voiding dysfunction? Neurourology and Urodynamics, online 5 July 2017, 10.1002/nau.23341