UCL Queen Square Institute of Neurology


Stroke Research


Axial CT scans showing acute cSAH and ICH*

Researching stroke prevention, treatment and management, and functional recovery after stroke.


Professor David Werring

Research Team

Research Goals

  • To understand the underlying mechanisms of cerebrovascular disease, with a focus on neuroimaging
  • To improve acute treatment and secondary prevention of stroke
  • To develop innovative treatments to prevent stroke, targeting both small and large artery diseases
  • To investigate how cerebral small vessel disease relates to intracerebral haemorrhage and vascular cognitive impairment
  • To increase knowledge of stroke genetics

Funded Research Projects

  • Prevention of hypertensive injury to the brain by intensive treatment: Intracerebral Haemorrhage. Funded by a Stroke Association Priority Programme Grant for Intracerebral Haemorrhage
  • Carotid Stenting Trialists’ Collaboration. Funded by the Stroke Association
  • Cerebral amyloid angiopathy cohort to characterize the natural history and establish biomarkers relevant to prognosis
  • CROMIS-2 (Clinical Relevance Of Microbleeds in Stroke)
  • PROHIBIT-ICH (Prevention Of Hypertensive Injury to the Brain by Intensive Treatment after IntraCerebral Haemorrhage: a pilot randomized trial of home telemetry-guided treatment)
  • OPTIMAS BHF: OPtimal TIMing of Anticoagulation after AF-associated acute ischaemic Stroke: a randomised controlled trial
Recent publications from Stroke Research

Jang YK, Kim HJ, Lee JS, Kim YJ, Kim KW, Kim Y, Jang H, Lee J, Lee JM, Kim S-J et al.  Distinctive clinical effects of haemorrhagic markers in cerebral amyloid angiopathy.  Scientific Reports 22 November 2017; 7(1):15984.  DOI: 10.1038/s41598-017-16298-1

Banerjee G, Summers M, Chan E, Wilson D, Charidimou A, Cipolotti L, Werring DJ.  Domain-specific characterisation of cognitive impairment following intracerebral haemorrhage.  International Journal of Stroke, online 1 November 2017.

Banerjee G, Carare R, Cordonnier C, Greenberg SM, Schneider JA, Smith EE, Buchem MV, Grond JV, Berbeek MM, Werring DJ.  The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice.  Journal of Neurology, Neurosurgery and Psychiatry 2017; 88(11): 982-994.  DOI: 10.1136/jnnp-2016-314697

Yakushiji Y, Charidimou A, Noguchi T, Nishihara M, Eriguchi M, Nanri Y, Kawaguchi A, Hirotsu T, Werring DJ, Hara H.  Total small vessel disease score in neurologically healthy Japanese adults in the Kashima scan study.  Internal Medicine, online 16 October 2017.  DOI:  10.2169/internalmedicine.8393-16

Banerjee G, Wilson D, Ambler G, Osei-Bonsu Appiah K, Shakeshaft C, Lunawat S, Cohen H, Yousry T, Lip GYH, Muir KW, Brown MM, Al-Shahi Salman R, Jager HR, Werring DJ, CROMIS-2 Collaborators.  Cognitive impairment before intracerebral hemorrhage is associated with cerebral amyloid angiopathy.  Stroke, online 15 December 2017. DOI: 10.1161/STROKEAHA.117.019409

Skrobot OA, Black SE, Chen C, DeCarli C, Erkinjuntti T, Ford GA, Kalaria RN, O'Brien J, Pantoni L, Pasquier F, Roman GC, Wallin A, Sachdev P, Skoog I, VICCCS group et al.   Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study.  Alzheimers Dement, online 19 October 2017.  DOI:  10.1016/j.jalz.2017.09.007

Jakel L, Van Nostrand WE, Nicoll JAR, Werring DJ, Verbeek MM.  Animal models of cerebral amyloid angiopathy.  Clin Sci (Lond) 2017; 131(19):2469-2488.  DOI: 10.1042/CS20170033

Hostettler Moreno I, Alg V, Shabi N, Jichi F, Bonner S, Walsh D, Bulters D, Kitchen N, Brown M, Houlden H et al. Characteristics of unruptured compared to ruptured intracranial aneurysms: A multicentre case-control study. Neurosurgery 2017 Jul 25. doi: 10.1093/neuros/nyx365. [Epub ahead of print]

Turner D, Scully M, Stone S, Werring DJ. Recurrent brain ischaemia and deep vein thrombosis: the clot thickens. Practical Neurology 2017 Oct;17(5):380-382. doi: 10.1136/practneurol-2016-001581. Epub 2017 Jun 3.

Skrobot OA, Love s, Kehoe PG, O’Brien J, Black S, Chen C, DeCarli C, Erkinjuntti T, ford GA, Kalaria RN et al. The vascular impairment of cognition classification consensus study. Alzheimer’s and Dementia 2017; 13(6):624-633 doi: 10.1016/j.jalz.2016.10.007. Epub 2016 Dec

Koohi N, Vickers DA, Lakshmanan R, Chandrashekar H, Werring DJ, Warren JD, Bamiou D-E. Hearing characteristics of stroke patients: prevalence and characteristics of hearing impairment and auditory processing disorders in stroke patients. Journal of the American Academy of Audiology 2017; 28(6):491-505 10.doi: 10.3766/jaaa.15139.

Wilson D, Seiffge DJ, Traenka C, Basir G, Purrucker JC, Rizos T, Sobowale OA, Sallinen H, Yeh S-J, Wu TY et al. Outcome of intracerebral haemorrhage associated with different oral anticoagulants. Neurology 2017; 88(18):1693-1700 doi: 10.1212/WNL.0000000000003886. Epub 2017 Apr 5.

Banerjee G, Kim HJ, Fox Z, Jaeger HR, Wilson D, Charidimou A, Na HK, Na DL, Seo SW, Werring DJ. MRI-visible perivascular space location is associated with Alzheimer’s disease independently of amyloid burden. Brain 2017; 140:1107-1116 doi: 10.1093/brain/awx003.

Koohi N, Vickers D, Warren J, Werring D, Bamiou DE. Long-term use benefits of personal frequency-modulated systems for speech in noise perception in patients with stroke with auditory processing deficits: A non-randomised controlled trial study. BMJ Open 2017; 7(4) http://dx.doi.org/10.1136/bmjopen-2016-013003

Wilson D, Chatterjee F, Farmer SF, Rudge P, McCarron MO, Cowley P, Werring DJ. Infratentorial superficial siderosis: classification, diagnostic criteria, and rational investigation pathway. Annals of Neurology 2017; 81(3):333-343 doi: 10.1002/ana.24850. Epub 2017 Jan 28.

Wilson D, Hostettler IC, Ambler G, Banerjee G, Jager HR, Werring DJ. Convexity subarachnoid haemorrhage has a high risk of intracerebral haemorrhage in suspected cerebral amyloid angiopathy. Journal of Neurology 2017; 264(4):664-673 doi: 10.1007/s00415-017-8398-y. Epub 2017 Feb 2.

Croall ID, Lohner V, Moynihan B, Khan U, Hassan A, O-Brien JT, Morris RG, Tozer DJ, Cambridge VC, Harkness K. Using DTI to assess white matter microstructure in cerebral small vessel disease (SVD) in multicentre studies. Clinical Science 2017; 131(2):1361-1373 doi: 10.1042/CS20170146. Print 2017 Jun 1.

Charidimou A, Imaizumi T, Moulin S, Biffi A, Samarasekera N, Yakushiji Y, Peeters A, Vandermeeren Y, Laloux P, Baron J-C et al. Brain Hemorrhage recurrence, small vessel disease type, and cerebral microbleeds: A meta-analysis. Neurology, 2017 Aug 22;89(8):820-829. doi: 10.1212/WNL.0000000000004259. Epub 2017 Jul 26.

Charimidou A, Turc G, Oppenheim C, Yan S, Scheitz JF, Erdur H, Klinger-Gratz PP, El-Koussy M, Takahashi W, Moriya Y et al. Microbleeds, cerebral haemorrhage, and functional outcome after stroke thrombolysis: individual patient data meta-analysis. Stroke, published online 18th July 2017 doi: 10.1161/STROKEAHA.116.012992. [Epub ahead of print]

Chan E, Altendorff S, Healy C, Werring DJ, Cipolotti L. The test accuracy of the Montreal Cognitive Assessment (MoCA) by stroke lateralisation. J Neurol Sci. 2017 Feb 15;373:100-104.doi: 10.1016/j.jns.2016.12.028. Epub 2016 Dec 19.

Charidimou A, Schmitt A, Wilson D, Yakushiji Y, Gregoire SM, Fox Z, Jäger HR, Werring DJ. The Cerebral Haemorrhage Anatomical RaTing inStrument (CHARTS): Development and assessment of reliability. J Neurol Sci. 2017 Jan 15;372:178-183.doi: 10.1016/j.jns.2016.11.021. Epub 2016 Nov 12. 

Jiad E, Gill SK, Krutikov M, Turner D, Parkinson MH, Curtis C, Werring DJ. When the heart rules the head: ischaemic stroke and intracerebral haemorrhage complicating infective endocarditis. Pract Neurol. 2017 Jan;17(1):28-34. doi: 10.1136/practneurol-2016-001469. Epub 2017 Jan 3.

Kongbunkiat K, Wilson D, Kasemsap N, Tiamkao S, Jichi F, Palumbo V, Hill MD, Buchan AM, Jung S, Mattle HP, Henninger N, Werring DJ. Leukoaraiosis, intracerebral hemorrhage, and functional outcome after acute stroke thrombolysis. Neurology. 2017 Feb 14;88(7):638-645. doi: 10.1212/WNL.0000000000003605. Epub 2017 Jan 27.

Koohi N, Vickers D, Chandrashekar H, Tsang B, Werring D, Bamiou DE2. Auditory rehabilitation after stroke: treatment of auditory processing disorders in stroke patients with personal frequency-modulated (FM) systems. Disabil Rehabil. 2017 Mar;39(6):586-593. doi: 10.3109/09638288.2016.1152608. Epub 2016 Mar 23.

Muir KW, Ford GA, Messow CM, Ford I, Murray A, Clifton A, Brown MM, Madigan J, Lenthall R, Robertson F, Dixit A, Cloud GC, Wardlaw J, Freeman J, White P; PISTE Investigators. Endovascular therapy for acute ischaemic stroke: the Pragmatic Ischaemic Stroke Thrombectomy Evaluation (PISTE) randomised, controlled trial. J Neurol Neurosurg Psychiatry. 2017 Jan;88(1):38-44. doi: 10.1136/jnnp-2016-314117. Epub 2016 Oct 18.

Wilson D, Werring DJ. Antithrombotic therapy in patients with cerebral microbleeds. Curr Opin Neurol. 2017 Feb;30(1):38-47. doi: 10.1097/WCO.0000000000000411.

Stroke Research Centre staff:

Amy Ashton (CRN Team)
Azra Banaras (CRN Team)
Dr Gargi Banerjee
Ekatherina Biggs
Professor Martin Brown
Simone Browning (SIGNaL)
Shahena Butt (PROHIBIT-ICH)
Hatice Capar (SIGNaL)
Dr Edgar Chan
Lucinda Crook (CRN Team)
Schederazade Feerick (CRN Team)
Loraine Fisch
Nina Francia (CRN Team)
Dr Isabel Hostettler Moreno
Siobhan McLernan
Sabaa Obaney (CRN Team)
Dr Richard Perry
Dr Robert Simister
John Mitchell (SIGNaL)
Dr David Seiffge
Sifelani Tshuma (CRN Team)
Caroline Watchurst (CRN Team Lead)
Professor David Werring (HoD BRR - Stroke Lead)
Dr Duncan Wilson


Further information

* Wilson et al. (2017) Convexity subarachnoid haemorrhage has a high risk of intracerebral haemorrhage in suspected cerebral amyloid angiopathy. Journal of Neurology, April 2017, Volume 264, Issue 4, pp 664–673. doi: 10.1007/s00415-017-8398-y.