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UCL Queen Square Institute of Neurology

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Neuroradiology

 

Voxel-based morphometry results showing (top) grey matter volume loss and (bottom) white matter volume loss in symptomatic ADAD mutation carriers compared to controls*

Establishing and applying imaging methods and biomarkers to transform the diagnosis, management and treatment of neurological and neurosurgical diseases

Lead:

Professor Tarek Yousry, Dr med Habil, FRCR

Research Team:

Research Goals

  • Research involving imaging method development and patient-cohort imaging studies covers a wide range of neurological and neurosurgical diseases, including neurovascular disorders, neurooncology, neurodegeneration and Neuroinflammation, as well muscle and peripheral nerves (neuromuscular) disorders. Our aim is to facilitate rapid translation of innovations, including intraoperative imaging, into the clinical environment.

Funded Research Projects

  • Secondary prevention of Alzheimer’s disease. Funded by the EU
  • GLINT: GlucoCEST imaging of neoplastic tumours. Funding from EC-H2020.
  • A gold standard perfusion phantom for quantitative MRI. Funded by SBRI NHS England.
  • High dose Simvastatin treatment for secondary progressive multiple sclerosis: impact on vascular perfusion and oxidative damage. Funded by the MS Society of GB & NI
  • Feasibility of microstructural and metabolic MRI fingerprinting of human gliomas. Funded by the NIHR BRC
  • Multi-centre optimization and harmonization of MRI image acquisition schemes: a UK-wide coordinated approach to advanced neuroimaging in dementia. Funded by Alzheimer’s Research UK
  • Multi-user ultra-high field clinical imaging research centre for London. Funded by the Wellcome Trust
  • Non-Invasive Imaging of glymphatic clearance: a novel strategy for the early diagnosis of Alzheimer's disease. Funded by EPSRC.
  • Imaging research to facilitate treatments for multiple sclerosis MS Society of GB
  • MRC centre for Neuromuscular disease, MRC
  • MYO-MRI COST Action- BM1304
Recent publications from Neuroradiology

Robertson NJ, Martinello K, Lingam I, Avdic-Belltheus A, Meehan C, Alonso-Alconada D, Ragab S, Bainbridge A, Sokolska M, Tachrount M, Golay X, et al. Melatonin as an adjunct to therapeutic hypothermia in a piglet model of neonatal encephalopathy: a translational study. Neurobiology of Disease, 2018, in press UCL Discovery

Zhu Y, Ramasawmy R, Johnson SP, Taylor V, Gibb A, Pedley RB, Chattopadhyay N, Lythgoe M, Golay X, Bradley D et al. Non-invasive imaging of disrupted protein homeostasis induced by proteasome inhibitor treatment using chemical exchange saturation transfer MRI. Scientific Reports, online 2 November 2018.

Mitra S, Kendall G, Bainbridge A, Sokolska M, Dinan M, Uria-Avellanal C, Price D, McKinnon K, Gunny R, Huertas-Ceballos A et al. Proton Magnetic Resonance Spectroscopy lactate/N-Acetylaspartate within two weeks of birth accurately predicts 2-year motor, cognitive and language outcomes in neonatal encephalopathy after therapeutic hypothermia. Archives of Disease in Childhood: Fetal and Neonatal, 2018 in press UCL Discovery

Selby NM, Blankestijn PJ, Boor P, Combe C, Eckardt K-U, Eikefjord E, Garcia-Fernandez N, Golay X, Gordon I, Grenier N, et al. Magnetic resonance imaging biomarkers for chronic kidney disease: a position paper from the European Cooperation in Science and Technology Action PARENCHIMA. Nephrol Dial Transplant 2018; 33 (suppl 2) ii4-ii14 UCL Discovery

Haddow LJ, Godi C, Sokolska M, Cardoso MJ, Oliver R, Winston A, Stohr W, Clarke A, Chen F, Williams IG et al. Brain perfusion, regional volumes and cognitive function in HIV positive patients treated with protease inhibitor monotherapy. Clin Infect Dis,2018, in press UCL Discovery

Golay XGGR, da Silva NA, Lohmann P, Fairney J, Magill AW, Oros Peusquens A-M, Choi C-H, Stirnberg R, Stoffels G, Galldiks N et al. Hybrid MR-PET of brain tumours using amino acid PET and chemical exchange saturation transfer MRI. European Journal of Nuclear Medicine and Molecular Imaging, 2018; 45(6):1031-1040 UCL Discovery

Rocca MA, Barkhof F, De Luca J, Frisen J et al, the MAGNIMS study group. The hippocampus in multiple sclerosis. Lancet Neurology 2018; 17(10):918-926.

Morrow JM, Evans MRB, Grider T, Sinclair CDJ, Thedens D, Shah S, Yousry TA, Hanna MG, Nopoulos P, Thornton JS et al. Validation of MRC Centre MRI calf muscle fat fraction protocol as an outcome measure in CMT1A. Neurology 2018 in press UCL Discovery

Thust S, Heiland S, Falini A, Jager R, Waldman AD, Sundgren PC, Godi C, Katsaros VK, Ramos A, Bargallo N et al. Glioma imaging in Europe: A survey of 220 centres and recommendations for best clinical practice. European Radiology 2018; 28(8):3306-3317 UCL Discovery

Major EO, Yousry TA, Clifford DB. Pathogenesis of progressive multifocal leukoencephalopathy and risks associated with treatments for multiple sclerosis: a decade of lessons learned. Lancet Neurology 2018; 17(7):578

Bugiardini E, Morrow JM, Shah S, Woods CL, Lynch DS, Pitmann AM, Reilly MM, Houlden H, Matthews E, Parton M Yousry T, et al. The diagnostic value of MRI pattern recognition in distal myopathies. Frontiers in Neurology 2018; 9-11 UCL Discovery

Scott CJ, Jiao J, Melbourne A, Burgos N, Cash DM, De Vita E, Markiewicz PJ, O'Connor A, Thomas DL, Weston PS et al. Reduced acquisition time PET pharmacokinetic modelling using simultaneous ASL-MRI: proof of concept. Journal of Cerebral Blood Flow and Metabolism 2018, in press UCL Discovery

Harrison IF, Diow B, Akilo AB, Evans PG, Ismail O, Ohene Y, Nahavandi P, Thomas DL, Lythgoe MF, Wells JA. Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with DTI MIRI. ELife 2018; 7:31 UCL Discovery

Barkhof F, Thomas DL. Mapping deep gray matter iron in multiple sclerosis by using quantitative magnetic susceptibility. Radiology 2018 in press UCL Discovery

Bisdas S, Shen H, Thust S, Katsaros V, Stranjalis G, Boskos C, Brandner S, Zhang J. Texture analysis- and support vector machine-assisted diffusional kurtosis imaging may allow in vivo gliomas grading and IDH-mutation status prediction: a preliminary study. Scientific Reports 2018; 8(1):6108.

Bishop CA, Ricotti V, Sinclair CDJ, Evans MRB, Butler JW, Morrow JM, Hanna MG, Matthews PM, Yousry TA, Muntoni F, John Thornton et al. Semi-automated analysis of diaphragmatic motion with dynamic magnetic resonance imaging in healthy controls and non-ambulant subjects with Duchenne Muscular Dystrophy. Frontiers in Neurology 2018; 9:26.

Boers AMM, Jansen IGH, Beenen LFM …Brown MM …Majoie CBLM. Association of follow-up infarct volume with functional outcome in acute ischemic stroke: a pooled analysis of seven randomized trials. Journal of Neurointerventional Surgery, online 7 April 2018.

Ciccarelli O, De Stefano N, Giorgio A …. Yousry T…Rovira A. Radiologically isolated syndrome or subclinical multiple sclerosis: MAGNIMS Consensus recommendations. Multiple Sclerosis Journal, online 1 February 2018.

Demetriou E, Tachrount M, Zaiss M, Shmueli K, Golay X. PRO-QUEST: a rapid assessment method based on progressive saturation for quantifying exchange rates using saturation times in CEST. Magnetic Resonance in Medicine, online 5 March 2018.

Geraldes R, Ciccarelli O, Barkhof F, De Stefano N….Yousry T …MAGNIMS study group. The current role of MRI in differentiating multiple sclerosis from its imaging mimics. Nature Reviews Neurology 2018; 14(4):213.

Golay XGGR, Riemer F, Solanky BS, Wheeler-Kingshott CAM. Bi-exponential 23NaT2* components analysis in the human brain. NMR in Biomedicine, online 26 Feb 2018.

Golay XGGR, da Silva NA, Lohmann P, Fairney J, Magill AW et al. Hybrid MR-PET of brain tumours using amino acid PET and chemical exchange saturation transfer MRI. European Journal of Nuclear Medicine and Molecular Imaging, online 16 April 2018.

Haller S, Vernooij MW, Kuijer JPA, Larsson E-M, Jäger HR, Barkhof F. Cerebral microbleeds: imaging and clinical significance. Radiology 2018; 287(1):11-28.

Kehoe PG, Blair PS, Howden B, Thomas DL …. Ben-Shlomo Y. The rationale and design of the reducing pathology in Alzheimer’s Disease through Angiotensin TaRgeting (RADAR) Trial
Journal of Alzheimer’s Disease, online 19 December 2018.

Major EO, Yousry TA, Clifford DB. Pathogenesis of progressive multifocal leukoencephalopathy and risks associated with treatments for multiple sclerosis: a decade of lessons learned. Lancet Neurology 2018; 17(5):467-480.

Miller DH, Lublin FD, Sormani MP …Yaldizli O, Macmanus DG, Yousry TA, …Wolinsky JS. Brain atrophy and disability worsening in primary progressive MS: Insights from the INFORMS study. Annals of Clinical and Translational Neurology, online 30 January 2018.

Muto M, Frauenfelder G, Senese R, Zeccolini F, Schena E, Giurazza F, Jäger HR. Dynamic susceptibility contrast (DSC) perfusion MRI in differential diagnosis between radionecrosis and neoangiogenesis in cerebral metastases using rCBV, rCBF and K2. La Radiologia Medica, online 5th March 2018.

Nery F, Gordon I, Thomas DL. Non-invasive renal perfusion imaging using arterial spin labelling MRI: challenges and opportunities. Diagnostics 2018; 8(1).

Parker TD, Slattery CF, Zhang J ….Thomas DL, Modat M, Cash DM, Crutch SJ, Alexander DC, Ourselin S, Fox NC, Zhang H, Schott JM. Cortical microstructure in young onset Alzheimer’s disease using neurite orientation dispersion and density imaging. Human Brain Mapping, online 25th March 2018.

Phyu P, Merwick A, Davagnanam I, Bolsover F, Jichi F, Wheeler-Kingshott C, Golay X, Hughes D, Cipolotti L, Murphy E, Lachmann RH, Werring DJ. Increased resting cerebral blood flow in adult Fabry disease: MRI arterial spin labelling study. Neurology 2018; 90(16):e1379-1385.

Pichat J, Iglesias JE, Yousry T, Ourselin S, Modat M. A survey of methods for 3D histology reconstruction. Medical Image Analysis 2018; 46:73-105.

Saba L, Yuan C, Hatsukami TS, Balu N… Jäger R et al. Carotid artery wall imaging: perspective and guidelines from the ASNR vessel wall imaging study group and expert consensus recommendations of the American Society of Neuroradiology. American Journal of Neuroradiology 2018; 39(2):E9-E31.

Schmierer K, McDowell A, Petrova N, Carassiti D, Thomas DL, Miquel ME. Quantifying multiple sclerosis pathology in post-morten spinal cord using MRI. NeuroImage, online 31st January 2018.

Thust SC, Hassanein S, Bisdas S, Rees JH, Hyare H, Maynard JA, Brandner S, Tur C, Jäger HR, Yousry TA, et al. Apparent diffusion coefficient for molecular subtyping of non-gadolinium-enhancing WHO grade II/III glioma: volumetric segmentation versus two-dimensional region of interest analysis. European Radiology online 23 March 2018.

Thust S, Heiland S, Falini A, Jäger R, Waldman AD, ….Vernooij MW, Yousry T et al. Glioma imaging in Europe: A survey of 220 centres and recommendations for best clinical practice. European Radiology, online 2nd March 2018, embargoed until 3rd Sept 2018.

Leeuwia A, Smith L, Melbourne A, Hughes A, Richards M, Prins N, Sokolska MJ, Atkinson D, Tillin T, Jager R et al. Cerebral blood flow and cognitive functioning in a community-based, multi-ethnic cohort: The SABRE study. Frontiers in Aging Neuroscience 2018; 10: article 279.

Cortese R, Magnollay L, Tur Gomez C, Abdel-Aziz K, Jacob A, De Angelis F, Yiannakas MC, Prados Carrasco F, Ourselin S, Yousry T et al.  The value of the central vein sign at 3T to differentiate MS from seropositive-NMOSD.  Neurology, online 31 December 2017.

Al-Hajri A, Al-Mughairi S, Somani A, An S, Liu J, Miserocchi A, McEvoy AW, Yousry T, Hoskote C, Thom M.  Pathology-MRI correlations in diffuse low-grade epilepsy associated tumors.  Journal of  Neuropathology and Experimental Neurology 2017; 76(12):1023-1033. DOI: 10.1093/jnen/nlx090

Sudre CH, Anson BG, Davagnanam I, Schmitt A, Mendelson AF, Prados F, Smith L, Atkinson D, Hughes AD, Chaturvedi N et al.   Bullseye's representation of cerebral white matter hyperintensities.  Journal of  Neuroradiology, online 11 November 2017. DOI:  10.1016/j.neurad.2017.10.001

Fox TA, Jager R, Ardeshna KM. Cerebrospinal fluid leak after bone marrow biopsy.  British Journal of Haematology.  Online 19 October 2017.  DOI:  10.1111/bjh.14963

Breitkopf M, Bisdas S, Liebsch M, Behling F, Bender B, Tatagiba M, Roder C.  Safety, utility and clinical results of continuous intraoperative electrophysiologic monitoring in 1.5T iMRI-guided surgery.  World Neurosurgery 2017; 106:198-205. DOI: 10.1016/j.wneu.2017.06.054

Akram H, Wu C, Hyam J, Foltynie T, Limousin P, De Vita E, Yousry T, Jahanshahi M, Hariz M, Behrens T et al. L-Dopa responsiveness is associated with distinctive connectivity patterns in advanced Parkinson’s Disease. Movement Disorders 2017; 32(6):874-883 doi: 10.1002/mds.27017. Epub 2017 May 8.

Skardelly M, Dangel E, Gohde J, Noell S, Behling F, Lepski G, Borchers C, Koch M, Schittenhelm J, Bisdas S, Naumann A, Paulsen F, Zips D, von Hehn U, Ritz R, Tatagiba MS, Tabatabai G. Prolonged Temozolomide maintenance therapy in newly diagnosed glioblastoma. Oncologist, online 30 March 2017 doi: 10.1634/theoncologist.2016-0347. Epub 2017 Mar 30.

Gold R, Arnold DL, Bar-Or A, Hutchinson M, Kappos L, Havrdova E, MacManus DG, Yousry TA et al. Long-term effects of delayed-release dimethyl fumarate in multiple sclerosis: Interim analysis of ENDORSE, a randomized extension study. Multiple Sclerosis Journal 2017 Feb;23(2):253-265 doi: 10.1177/1352458516649037. Epub 2016 Jul 11.

Mok T, Jaunmuktane Z, Joiner S, Campbell T, Morgan C, Wakerley B, Golestani F, Rudge P, Mead S, Jäger HR, Wadsworth JD, Brandner S, Collinge J. Variant Creutzfeldt-Jakob Disease in a Patient with Heterozygosity at PRNP Codon 129. N Engl J Med. 2017 Jan 19;376(3):292-294 doi: 10.1056/NEJMc1610003.

Damjanovic D, Valsasina P, Rocca MA, Stromillo ML, Gallo A, Enzinger C, Hulst HE, Rovira A, Muhlert N, De Stefano N et al. Hippocampal and deep gray matter nuclei atrophy is relevant for explaining cognitive impairment in MS: A multicentre study. AJNR American Journal of Neuroradiology, 2017 Jan;38(1):18-24. doi: 10.3174/ajnr.A4952. Epub 2016 Sep 29.

Tentolouris-Piperas V, Ryan NS, Thomas DL, Kinnunen KM. Brain imaging evidence of early involvement of subcortical regions in familial and sporadic Alzheimer's disease. Brain Research 2017; 1655:23-32 doi: 10.1016/j.brainres.2016.11.011. Epub 2016 Nov 12.doi: 10.1016/j.ejpn.2016.06.001. Epub 2016 Jun 20.

Thornton JS. Technical challenges and safety of magnetic resonance imaging with in situ neuromodulation from spine to brain. Eur J Paediatr Neurol. 2017 Jan;21(1):232-241 doi: 10.1016/j.ejpn.2016.06.001. Epub 2016 Jun 20.

Zarkali A, Gorgoraptis N, Miller R, John L, Merve A, Thust S, Jager R, Kullmann D, Swayne O. CD8+ encephalitis: a severe but treatable HIV-related acute encephalopathy. Pract Neurol. 2017 Jan;17(1):42-46 doi: 10.1136/practneurol-2016-001483. Epub 2016 Nov 1.

Massey LA, Miranda MA, Al-Helli O, Parkes HG, Thornton JS, So PW, White MJ, Mancini L, Strand C, Holton J et al. 9.4 MR microscopy of the substantia nigra with pathological validation in controls and disease. NeuroImage: Clinical 2016: 13:154-163 eCollection 2017.

Desai RA, Davies AL, Tachrount M, Kasti M, Laulund F, Golay X, Smith KJ. Cause and prevention of demyelination in a model multiple sclerosis lesion. Annals of Neurology 2016; 79(4):591-604 doi: 10.1002/ana.24607. Epub 2016 Feb 22.

De Vita E, Ridgway GR, White MJ, Porter MC, Caine D, Rudge P, Collinge J, Yousry TA, Jager HR, Mead S, Thornton JS, Hyare H. Neuroanatomical correlates of prion disease progression - a 3T longitudinal voxel-based morphometry study. NeuroImage Clinical 2016 Nov 2;13:89-96. eCollection 2017

Further information

 * Tentolouris-Piperas et al (2017). Brain imaging evidence of early involvement of subcortical regions in familial and sporadic Alzheimer's disease. Brain Research Volume 1655, 15 January 2017, Pages 23-32. doi.org/10.1016/j.brainres.2016.11.011