UCL Queen Square Institute of Neurology

Prof Sebastian Brandner

Prof Sebastian Brandner

Professor of Neuropathology

Neurodegenerative Diseases

UCL Queen Square Institute of Neurology

Joined UCL
1st Mar 2004

Research summary

Model system to study the cell of origin of brain tumours

We established of mouse models for brain tumours. One of our key achievements is the demonstration of a genotype-phenotype correlation brain tumours. Molecular profiling of mouse tumours could demonstrate a strong correlation to certain types of human gliomas, thus making it a valuable model for technology development, and biomarker discovery. We have recently discovered biomarkers (miR-449a and GPR158) that correlate with survival of patients with gliomas, making it a potential druggable target. Results published in EMBO Journal, Cancer Research, Disease Models and Mechanisms, and Oncogene. Collaborative work published in Cancer cell or PNAS


In the field of neurodegeneration, I led two national vCJD surveillance studies, published in BMJ and a study on the human transmission of amyloid beta through medical procedures, published in Nature and Acta Neuropathologica.

Teaching summary



Royal College of Pathologists, UK
Doctorate, Fellow of the Royal College of Pathologists | 2002
Universitat Zurich
Doctorate, Habilitation | 2000
Georg-August-Universität Göttingen
Doctorate, Doctor of Medicine | 1991


•   EORTC (European Organisation into Research and Treatment of Cancer) |  •  EANO (European Association of Neuro-oncology)  | •  International Collaboration for Cancer Reporting (ICCR): guideline committee  | •  NICE guideline committee (Brain tumours) member  | •  Council member Royal College of Pathologists (from Nov 2017)  | •  British neuro-oncology society board member |  •  British neuropathology society, clinical practice group (CPC) and specialty advisory committee (SAC) |  •  Interspecialty Committee on Molecular Pathology, committee member


2001:         Honorary Consultant at the Division of Neuropathology, NHNN, University College Hospitals, and Senior Neuropathologist, MRC Prion Unit London UK

2000:        Privatdozent (Reader) in Neuropathology; University of Zürich, Switzerland

1998:        Oberarzt (Consultant) in Neuropathology, University Hospital Zürich, Switzerland

1993:        Assistenzarzt (Specialist registrar) and Clinical Fellow in Neuropathology, University Hospital Zürich, Switzerland

1991:        AiP (Senior House officer) in Neurosurgery, University Hospital Tübingen, Germany


2008:         FRCPath Neuropathology (Royal College of Pathologists)

2003:         MRCPath Neuropathology (Royal College of Pathologists)

2000:         Habilitation (Venia Legendi) in Neuropathology University of Zurich

1991:         Medical Degree University of Göttingen, Germany