UCL Queen Square Institute of Neurology


Video: Parkinson's UK site visit for the Targeting LRRK2 project

1 November 2011

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LRRK2 from Tony Cox on Vimeo.

LRRK2 – pronounced lark 2 – is the most common gene associated with Parkinson’s. A mutant form of LRRK2 can cause the death of nerve cells, and blocking this form of LRRK2 from working can prevent this from happening. Before we can use this knowledge to develop treatments we need to fill in the gaps in our understanding of the role LRRK2 plays when it’s healthy, and of the different proteins it interacts with along the way within the nerve cell.

Figuring out how LRRK2 works and how to change this is a promising route to developing novel therapies for the treatment and ultimately cure for Parkinson’s. Although a long way off, we hope that these can ultimately be tested in the clinic to see if we can slow down or alter the progress of the condition.

Patrick Lewis - Lead researcher for the Targeting LRRK2 project

Patrick Lewis' profile

More information (PDF) on the Targeting LRRK2 project

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