UCL Institute of Neurology


Stiff-person Syndrome

NLM Medline definition of stiff-person syndrome: A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles.  Respiration may become impaired in advance cases.

Stiff-person Syndrome factsheet: NINDS, the National Institute of Neurological Disorders and Stroke (US site)

Pubmed Medline search on stiff-person syndrome

Support groups

The aims of Neurosupport are to provide advice, information and support to people with a neurological condition, their families and care professionals, and to raise the awareness of neurological conditions in the community at large.

National Organization for Rare Disorders (NORD) (US site)