Neuroprotective B cell Immunomodulatory Therapy for Traumatic Brain Injury: Ruxandra F. Sîrbulescu

Due to the complex nature of central nervous system (CNS) injury, clinically effective therapies for such conditions have proven challenging to develop. No therapeutics that adequately address the chronic inflammatory component of secondary CNS injury are currently available. Recently, B lymphocytes have gained attention for their role in maintaining immune homeostasis and regulating inflammatory responses in the context of tissue injury. Our group and others have shown that exogenous B cells can be applied therapeutically to restore function in multiple pre-clinical injury models, including traumatic brain injury. This talk will review recent investigations into cellular mechanisms of immunomodulation associated with intraparenchymal delivery of mature naïve B lymphocytes at the time of injury.