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Crick-HEI Seminar: Jernej Ule : How do protein-RNA condensates form and contribute to disease? 

28 February 2022, 12:30 pm–1:00 pm

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The Crick and its Partner HEIs have started a new seminar series to share some of the research that staff on the attachment and joint recruitment programmes are undertaking

Event Information

Open to

UCL staff | UCL students

Availability

Yes

Organiser

Andrea Hodgetts

This virtual seminar series will feature talks given by university staff who are based either part-time or full-time in the Crick. Presenters will be introduced by a Crick host, before discussing their current research and then opening the floor to questions.  The seminars are free and are open to all staff and students at King's, Imperial, UCL and the Crick.

  • UCL Presenter: Professor Jernej Ule : How do protein-RNA condensates form and contribute to disease?  
  • Crick Host: Sila Ultanir

Mutations in many genes encoding RNA-binding proteins (RBPs) cause neurologic diseases, and these tend to be located within intrinsically disordered regions (IDRs). To understand how these mutations act, we employed crosslinking and Immunoprecipitation (CLIP) to obtain maps of in vivo protein-RNA and RNA-RNA interactions. This showed that changes in IDRs can selectively tune the RNA binding properties and functions of an RBP, which are additionally shaped by the arrangements of RNA binding motifs and RNA structure. Taken together, I'll discuss transcriptomic approaches that can unravel the specificity of RBP condensation, and how this opens new doors for understanding signalling, disease and evolution.

About the Speaker

Professor Jernej Ule