Virtual: Brain meeting: Dr Ritwik Niyogi

Brain meeting 

Abstract:

Anergia – the reduced propensity to act vigorously by working faster, longer, and expending more energy – is one of the most prevalent symptoms of depression in the DSM-5. It can be easily measured in both humans and animals, but can have multiple causes. Individuals could have low vigour because they find rewards less rewarding, or costs of acting quickly more costly, or both. I will propose using vigour-anergia as a measure of depressive symptoms and harness approaches from computational psychiatry to dissect its underlying causes and mechanisms. I will present an integrative account of my work across multiple levels: neural circuits, in-vivo rodent assays, human behaviour and computational modelling, with the goal of bridging the animal to human translational spectrum.