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CNT Seminar: Andre Altmann

12 December 2019, 4:00 pm–5:00 pm

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Combining imaging and genetics to better understand brain disorders

Event Information

Open to

All

Cost

£0.00

Organiser

Centre for Neuroimaging Techniques

Location

4th floor seminar room
12 Queen Square
Queen Square
London
WC1N 3AR
United Kingdom

CNT Seminar

  

 

Abstract:

In this talk I will speak about imaging genetics and its application to brain disorders, in particular Alzheimer’s disease and Epilepsy. In imaging genetics measures derived from (neuro-)imaging are used as endpoints in statistical analyses of genetic data. This is in contrast to conducting such studies with dichotomous case-control labels.

Replacing crisp diagnostic labels with imaging marker that are thought to better reflect the disease process are expected to lend increased statistical power to such analyses and also allow to investigate different aspects of the underlying disease process.

In the second half I will talk about leveraging synergies between of data sources that are available in a common neurological reference space. In particular, this concept will be showcased by combining brain atrophy maps with gene expression data from the Allen Human Brain Atlas to generate hypotheses about underlying disease processes.

About the Speaker

Andre Altmann

MRC Senior Fellow at Dept of Med Phys & Biomedical Eng, Faculty of Engineering Science, UCL

More about Andre Altmann