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Visitors should report to the security front desk in Queen Square House (Institute of Neurology), the 11-storey tower block on the north corner of Queen Square.
Division of Neuropathology, Box 126
UCL Institute of Neurology
The National Hospital For Neurology and Neurosurgery
London WC1N 3BG
Telephone: 020 344 84234
Fax: 020 344 84486
For patient related enquiries:
020 344 84236
Dubowitz Neuromuscular Centre:
020 344 84235
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Prof. Sebastian Brandner (Head of Division)
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Molecular Neuro-Oncology: I provide a comprehensive Neuro-oncology service for the National Hospital (more than 200 tests annually) and for referring Hospitals (more than 200 tests p.a.). We routinely perform tests for LOH1p/19q, EGFR amplification, IDH mutation (immunohistochemical detection and sequencing) and other markers that are relevant for the prognosis of high grade gliomas, (LOH10q, PDGFRa, LOH NF1) and MGMT Promoter methylation. We test for the KIAA:BRAF fusion transcript and the V600E mutation, which have diagnostic and prognostic relevance for pilocytic astrocytomas, and other low grade glial tumours of the nervous system (read more on molecular pathology tests).
Diagnostic Neuro-oncology: In rotation with all other consultants in the department, we diagnose all surgical Neuropathology in the Department. We diagnose more than 1100 brain tumours and pituitary adenomas every year. All consultants in the department have the expertise to diagnose common and rare brain cancers and other surgical neuropathology cases. Soft tissue and haematological malignancies are routinely referred for expert second opinion.
Prion disease: In close cooperation with the National Prion Clinic and the MRC Prion Unit I carry out ca 50 post mortem examinations of sporadic, familial and acquired prion disease every year. Thanks to the cooperation with families to consent the brain tissue to be used for research, we were able to build up a unique resource of research tissues with all types of prion diseases.
Peripheral Neuropathies: Together with Dr Phadke, I diagnose approximately 120 peripheral nerve biopsies per year. Most peripheral Neuropathies are of inflammatory nature and we have developed considerable expertise and interest in the differential diagnosis of inflammatory neuropathies. A broad range of specialist techniques are used in the diagnosis of inflammatory neuropathies. We have a close interaction with the clinical team to discuss the investigation of each neuropathy individually (read more about the centre for Neuromuscular Diseases).
· Royal College of Pathologists (www.rcpath.org)
· British Society of Neuropathologists (www.bns.org.uk)
· American Association of Neuropathologists (AANP)
· Society for Neuroscience (SfN, USA)
· German Society of Neuroscience
· British Neuro-Oncology Society (www.bnos.org.uk)
· Swiss Society of Experimental Biology (USGEB)
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Page last modified on 04 may 14 22:00