Dr M. Edwards

Dr Mark J Edwards

Pathophysiology of Human Movement Disorders

Movement disorders cover a diverse range of neurological conditions from Parkinson’s disease to tremor and dystonia. They are thought of primarily as disorders of basal ganglia function, but the consequences of such dysfunction and the contribution of other brain areas are only beginning to be understood. Our current research has three broad aims: 1) To improve and develop clinical categorisation of movement disorders by researching electrophysiological “signatures” or biomarkers of particular disorders, 2) to use electrophysiological and psychophysical techniques to explore the pathophysiology of different movement disorders and 3) to research the possible application of rTMS in the treatment of movement disorders.

We are based in number 33 Queen Square with access to state of the art electrophysiology labs.

We use the following techniques:

- Transcranial magnetic stimulation to measure various parameters of cortical excitability.

- Repetitive transcranial magnetic stimulation, paired associative stimulation to explore brain plasticity.

- EEG

- Psychophysical assessments of reaction time, attention and learning.

Currently we are encouraging referral of musician’s with dystonia.  We would like to establish a specific clinic for this type of dystonia and have a number of interesting research projects currently underway which will hopefully improve understanding of this condition and aid development of new treatments.  If you have this form of dystonia and would like to be seen in clinic or are interested in taking part in studies please email Dr Edwards via: m.j.edwards@ucl.ac.uk.

Current Lab Members

Dr Tabish Saifee: Tabish is exploring the pathophysiology of neuropathic tremor in conjunction with the MRC neuromuscular unit (Dr Mary Reilly). Neuropathic tremor is a poorly understood form of tremor, and provides an intriguing model of a peripherally triggered tremor disorder.

Dr Isabel Parees: Isabel is exploring the pathophysiology of functional movement disorders. This diverse and complex group of disorders presents major challenges in diagnosis, understanding of pathophysiology and treatment.

Dr Panagiotis Kassavetis: Panagiotis is exploring the influence of afferent input in the pathophysiology of dystonia. There is considerable evidence of disturbed processing of afferent feedback in dystonia, and this may play a primary role in some forms of the disorder.

Dr Anna Sadnicka: Anna is using different brain stimulation techniques and unique clinical populations of patients with rare types of dystonia to explore the contribution of cerebellar dysfunction to motor and non-motor features of dystonia.

Collaborators:

Prof. Kailash Bhatia

Prof John Rothwell

Prof Patrick Haggard

Dr Katerina Fotopolou

Dr Jon Stone

Dr Alan Carson

Dr Karin Roelofs (Netherlands)

Dr Bart Van De Warrenberg & Britt Hoffland (Netherlands)

Dr Ying-Zu Huang (Taiwan)

Grant Support:

National Institute of Health Research (NIHR), Guarantors of Brain, Dystonia Society UK, Parkinson’s Disease UK

Page last modified on 18 apr 12 10:08