Current areas of research: neurogenetics; movement disorders; dementia; genetics and pathology of tauopathies like PSP and CBD; clinical features and genetics of early onset and familial Parkinson’s.
1. Genetics in early onset and familial Parkinson’s: leading a large-scale family-based genetic study of Parkinson’s disease, focusing on early onset and familial Parkinson’s. This will involve genetic analysis directed towards small families for monogenic gene discovery research. Aims to identify new families where both affected and unaffected individuals are prepared to participate in neurogenetics research.
2. Genetics and pathology of PSP and CBD: leading a longitudinal UK-wide study of PSP, CBD and MSA with the aim to: i.) improve the diagnosis of early PSP, CBD and MSA, ii.) develop markers, which can assist with early diagnoses, monitoring disease progression and understanding pathogenesis, iii.) establish a cohort of carefully studied patients for future studies and improve the understanding of the longitudinal progression of the disease and the emergence of the prototypic neurological syndromes.
3. Visual cognition in Parkinson’s disease: examining visual processes in patients with Parkinson’s compared to healthy controls.
4. European Registry for CBD: building a European network of patients with CBS who will be available for future therapeutic, biomarker, genetic and clinico-pathological studies.