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T-cell Differentiation & Asthma
Tessa Crompton is GOSHCC Professor of Experimental Immunology at UCL. Her research group focus on the regulation of lymphocyte and erythrocyte differentiation and function by the cell's environment, particularly the role of morphogen signaling in the determination of T-lineage cell fate. The specialized environment of the thymus is essential for efficient production of functional non-self reactive T cells. They aim to understand the way in which signals from the thymic epithelium direct the differentiation of developing T-lineage cells, and likewise to understand how microenvironmental factors such as morphogen signaling influence the outcome of T-cell receptor (TCR)-ligation in mature peripheral T-cell function and differentiation. In addition, they investigate the influence of Hedgehog signaling on erythrocyte lineage commitment and differentiation in the bone marrow during normal haematopoiesis and in the spleen during stress-induced erythropoiesis.
Tessa completed her PhD at UCL in 1990, and after post-doctoral training in Lausanne, Marseille and London, she set up her own laboratory at Imperial College London in 1998. In 2007 she moved her lab to UCL Institute of Child Health.
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Email address: t.crompton@ucl.ac.uk