T-cells and Immune Regulation
David Sansom is Professor and Chair in Transplant Immunology at UCL Institute of Immunity and Transplantation.
His major research interests involve investigating fundamental aspects of how T cells determine whether to make immune responses or not. In particular focusing on the interplay between two receptors on T cells, CD28 and CTLA-4 and their binding partners, CD80 and CD86. His lab's work on the underlying molecular and cellular mechanisms has led to advances in understanding how the CD28/CTLA-4 system functions and this knowledge has been used to develop tests of human T cell function and regulatory T cell suppression.
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