UCL Division of Infection & Immunity

Athena SWAN Silver Award

External Seminar
1pm | 15 Jan | Roberts G06 LT
Internal Seminar
1pm | 16 Jan | Cruciform LT1
Virtual Virology
4pm | 18 Jan | Christopher Ingold XLG1 LT

More I&I Events »

Undergraduate Modules

Students in Lab

IMMN2001 Immunology

A comprehensive introduction to the immune system. We will start by looking at the various cells and molecules that are involved, and explore their functional organisation. We will ask some basic questions such as how does the immune system know what to respond to?, and how does it eliminate infection?. We will go on to discuss the concept of immunological memory and how vaccination works. Like any complex machine, there are multiple ways in which the immune system can malfunction. Once you have an understanding of the ‘nuts and bolts’ of the immune system, and grasped some of the main concepts behind how it functions in a healthy individual, we will move on to talk about disease situations associated with imbalanced immunity, including immunodeficiencies, allergy and autoimmunity. We will also look at the medically very important field of transplantation, and investigate the potential for the immune system to fight different types of cancer.

The module is assessed by a final unseen examination (100%).

Module Tutor: Dr Milica Vukmanovic-Stejic

Student Feedback:

This course gave every opportunity for involvement of students during the lectures. I liked this very much. I feel all the lectures were delivered extremely well.

Course contents were just right as an introductory course. Lots of resources (especially revision casts) were very helpful. Essay topic was relevant to most of the topics we covered - hence aided revision as well.

INFN2001 Infection

This module provides a basic foundation in the fascinating and important discipline of infection. Common pathogens, including bacteria, viruses, fungi and parasites are discussed in relation to their biology and the diseases they cause. The focus of the module is pathogenicity: the capacity to cause disease. We will consider: how the immune system provides protection against infection; how pathogens manage to flourish in the face of the formidable array of host protective mechanisms; how vaccines and drugs can be used in the fight against infection. Considerable emphasis will be placed on critical discussion of these core concepts.

The module is assessed by a coursework essay(100%).

Module Tutor: Dr Richard Milne

Student Feedback:

Really allowed me to think about infection in a whole new perspective… lectures directed my thinking in a very interesting way. Rather than just thinking about how pathogens cause harm, there was a more in depth discussion about why they caused harm, and what forces help shape a pathogen into what they are. I could also appreciate the sheer diversity of pathogenic mechanisms.

I liked the content, the availability of lecturecast, the quizzes, and the readiness of all the lecturers to respond to questions. I felt that all the lecturers, particularly the course organiser seemed to be very helpful and genuinely committed to making the course as good as it can be.

INIM3010 Global Eradication of Viruses (new module from 2017-18)

(Term 2, Common Timetable Block D, Tuesdays: 11.00 - 13.00 and Thursdays: 9.00 - 11.00)

This module will take a worldwide perspective on control of virus infections in humans. The scientific principles that have so far allowed three viruses to be eradicated from the globe will be emphasised. Lectures will deal with individual viruses, outlining their medical impact, extent of current control in the population, their potential for eradication and progress towards achieving that ultimate goal.

The content will allow students to compare and contrast the transmission, medical impacts and control by immunisation at the population level of distinct viruses.

Students will have knowledge of:

1. The key characteristics of selected viruses that currently cause widespread infection in humans

2. Key aspects of the protective immune responses to these infectious agents

3. The factors that must be induced by vaccines in order to provide protective immunity

4. The requirements for this protection to be extended so that transmission in the community can be interrupted, leading ultimately to global eradication

5. Important contemporary issues surrounding international collaboration, funding and political will that leads some infectious diseases to be targeted for eradication

The module will be assessed by a written assessment/proposal (60%) and an oral presentation (40%).

Module Lead: Professor Paul Griffiths

INIM3011 Evolution and Infectious Diseases (new module from 2017-18)

(Term 2, Common Timetable Block F, Mondays: 14.00 - 17.00)

This module will cover the basics of evolution, and demonstrate how this process determines the changing relationship between pathogen and host. It will cover such topics as mutation, selection, recombination and horizontal transfer, the ‘arms race’ between host and pathogen, evolution of virulence, vaccines, drug resistance, and the somatic evolution of the immune system.

Improved insight into these concepts has been associated with the development of new sequencing methodologies.  A practical component will use the web-based genomic analysis tool Galaxy to introduce students to such analyses as sequence extraction and assembly, alignment, phylogenetics, and selection analysis.

Learning outcomes:

1. Understand the basics of evolutionary biology; variation, differential fitness, and selection.

2. Understand how these concepts relate to pathogens and their interactions with the host. 

3. Understand how these evolutionary processes are relevant to strategies of disease control, such as drug development and vaccination.

4. Have familiarity with a variety of methods that have been developed to study these evolutionary factors and processes from a genomics perspective, including the processing of next generation sequencing data and their analysis in terms of phylogenetics, population genetics, and analysis of selection.

The module will be assessed by an essay (70%) and a series of online quizzes (30%).

Module Lead: Professor Richard Goldstein

IICS0001 Mathematical Modeling in Biomedicine (new module from 2017-18)

(Term 2, Common Timetable Block E, Wednesdays: 11.00 - 13.00 and Fridays: 9.00 - 11.00)

Mathematical models provide a way to capture the essential features of complex systems, which often help scientists to gain insight and understanding, and crucially allow the behaviour of the system to be accurately predicted. Such models are pervasive in physics and chemistry, but have been slower to develop in biology and medicine due to the perceived complexity and heterogeneity of biological systems. However, mathematical models are increasingly being applied to make sense of the huge volumes of biological data produced by modern technologies.

This module aims to expose the student to the range of applications of mathematical models in biomedicine, through a series of seminars by experts. Examples will cover mathematical models operating at widely different time and distance scales, ranging from models of molecular structure, enzyme and receptor kinetics, cellular and organ imaging, neuronal processing and brain function, genomics, epidemiology and evolution.

Students will learn to understand the main approaches to representing biological and medical processes by mathematical models (e.g. deterministic versus stochastic, mechanistic versus statistical), by a guided in depth study of primary literature in this field. Students will also have an opportunity to do some modelling themselves, and to become familiar with how to conceptualize, develop and implement a biological model using a high level computer programing language.

The module will be assessed by an oral presentation (40%) and a mini project (60%).

An A in A level mathematics (or equivalent) is an essential prerequisite for the module. Some prior experience of computer programing is an advantage but not essential (catch up tuition will be provided).

Module Lead: Professor Benny Chain

INIM3002 Immunology in Health & Disease

(Term 1, Common Timetable Block C, Mondays: 11.00 - 13.00 and Wednesdays: 9.00 - 11.00)

Immunology in Health and Disease provides an overview of the human immune system. Starting at the molecular level (e.g. antigen recognition, antibody diversity), outlining what is known about cellular interactions within the immune system (e.g. cytokines and immunoregulation) and concluding with a consideration of the role of the immune system in host defence, its role in disease, and its possible role in determining ecology and evolution of the species. The module will cover the anatomy and constituents of the immune system and then consider the general principle of how an immune response is generated, beginning with the initial innate immune response to the development of acquired immunity. These concepts will be placed in context: how the immune system fights pathogens, how inappropriate responses can cause disease and how the immune system can be manipulated therapeutically. The module will develop from a basic to a more in depth understanding, with emphasis throughout placed on current developments in this fast moving field.

The module is assessed by an unseen final examination (80%) and an online quiz (20%).

Module Lead: Dr Milica Vukmanovic-Stejic

Student feedback:

Very well-organised and well-taught. Content is very interesting. 

This lecture/seminar was immensely informative but clear and I really liked the focus on research data. At the same time it was combined with the theoretical background which made it easier to go into the data.

It was a good module and most of the lectures were interesting. There was a good quality of teaching. The module was taught from basic principles and level of complexity built up slowly. Thank you.

INIM3003 Infectious Agents 

(Term 1, Common Timetable Block A, Mondays: 9.00 - 11.00 and Thursdays: 11.00 - 13.00)

The Infectious Agents module provides state-of-the-art coverage of a selection of current issues in the field of infection. No attempt is made to cover a comprehensive curriculum but, instead, students will learn the language and concepts of the field through specific research-led examples and active discussions. Themed teaching sessions given by experts comprise an introduction to the topic followed by discussion and critique of a recent paper. Papers will be provided in advance and students will be expected to come to sessions prepared to discuss the set paper critically. In some sessions students will be required to lead discussions. Assessment is a short presentation of a chosen paper and a written commentary based on this. The focus throughout the module is on reading and discussing primary literature: full participation in class discussions is essential.

The module is assessed by an in-course assessment (100%).

Module Lead: Dr Richard Milne

Student feedback:

I really like the way that the lectures were set up with 1 hour of lecture and 1 hour of paper critique. This module has vastly improved my ability to read and interpret primary scientific papers and has given me more confidence to speak up and give my opinions in class. The elevator pitch was a really nice change from the usual essay as an in-course assessment.

I like how it is balanced between current research discussion vs. traditional lecture, much better than just having two hours of traditional lectures.. that would be so boring.. instead this gives student the initiative to read up more of what they are interested in.

Watching other people's elevator pitch sessions was awesome. Being exposed to so much research in such a short space of time and then thinking about them critically was an invaluable exercise. In general the module was exciting and fun, as each week the papers were quite interesting and the research incredibly current.

The fact that each session was based around a paper is the best thing about this module. It forced me to do the reading and it's much more interesting to learn from real research than from a textbook. The interactive nature of the sessions is also a fantastic idea.

INIM3004 Cellular Pathology

(Term 1, Common Timetable Block D, Tuesday 11.00 - 13.00 and Thursday 9.00 - 11.00)

Cellular pathology encompasses the mechanisms by which dysfunction of cellular processes contributes to the pathogenesis of disease. In this module, we aim to give you an in-depth understanding of key cellular processes, to introduce the contemporary experimental approaches that are used to study them and to highlight the mechanisms by which their dysfunction can cause disease. The module is organised to exploit the strengths of teaching in the context of a research-rich university. The topics covered are chosen partly on their importance and partly to reflect the specific research strengths within UCL: all the lectures are given by top researchers in the field. Given the scope of molecular cell biology, the module cannot be comprehensive. Nor is it feasible in a single lecture to exhaustively cover even a single topic (for example the cell cycle). The objectives are to provide: a sufficient basic knowledge of the major processes of the cell; a flavour of what are the outstanding questions driving research in the field at present and how these could be tackled; and to equip students to begin to consider the intricate connection between cellular processes and disease.

The module is assessed by an unseen final examination (80%) and a coursework essay (20%).

Module Lead: Dr Matthew Reeves

Student feedback:

Very interesting and motivating… most of the students got really involved where some of the information overlapped with what we knew from earlier years and then it fluently, gradually got more complicated and then was backed up with interesting research evidence.

I think it was a demanding and challenging module covering a broad range of topics and thus it was interesting to study… obviously, it is important to understand the cell biology principles in a healthy and a diseased organism.

Interesting variety of topics. It was clear that a lot of planning and thought went into the choice of lectures and lecturers. The module was very well organised and I liked the structure.

VIRL3001 Molecular Virology 

(Term 1, Common Timetable Block B, Tuesdays 9.00 - 11.00 and Fridays 11.00 - 13.00)

The aim of the module is to give students an up to date insight into molecular virology, with particular focus on human pathogens and new research developments in the field. Lectures will cover a selection of important human viral pathogens: herpesviruses, retroviruses including HIV, hepatitis viruses, human papilloma viruses and Influenza viruses, chosen to reflect clinical and research expertise within UCL. The molecular aspects of virus replication will also be put in a broader context of disease pathogenesis and therapy, with lectures covering viruses and cancer, emerging viruses, viral immunology antiviral therapy and vaccines.

The module is assessed by an unseen final examination (80%) and a coursework essay (20%).

Module Lead: Dr Richard Milne

Student feedback:

The module is very exciting, extremely informative and is very inspiring. The course content is all relevant, and is challenging.

I enjoyed the variety of topics, the amount of different speakers and how the lectures are focused on very recent research.

INIM3001 Laboratory-Based Research Project (Term 1 & 2)

This research project module, available only to Infection and Immunity students, aims to give you first-hand experience of original laboratory research under direct supervision of principal investigators at UCL. We assess the aspirations of each student individually to identify their preferences for potential types of project that are relevant to the broad scope of the iBSc. Together with their supervisor, students will then formulate a specific project, design and undertake experiments, and interpret /communicate their work in oral presentations and a written report. This module provides invaluable teaching in scientific methodology, laboratory techniques, critical appraisal of original experimental data, and unique insight into the potential of new discoveries. The skills acquired here provide a competitive platform for students who may wish to pursue a future research or clinical academic career.

Module Lead: Dr Richard Milne

INIM3005 Immunodeficiency & Therapeutics

(Term 2, Common Timetable Block B, Tuesdays 9.00 - 11.00 and Fridays 11.00 - 13.00)

The immune system comprises components that are involved in recognition of invading pathogens and other noxious agents, microbial killing and tissue homeostasis/repair. Therefore, deficiencies of the immune system can be associated with increased susceptibility to infectious disease or a failure to control inflammation. The study of immunodeficiencies has in fact contributed extensively to our current understanding of normal structure and function in the immune system, and in turn has led innovative approaches to manipulate immune responses for therapeutic purposes. This module seeks to explore the broad repertoire of both genetic (primary immunodeficiency) and environmental (secondary immunodeficiency) causes of impaired immunity, together with the consequences for the patient of such deficiencies and the insights provided into our understanding of the normal immune system. The treatment options that are available for these will be discussed, as well as approaches to immunomodulation including research which aims to transform gene and cell therapies into clinical applications.

In this module we aim to give you the framework and examples by which:

1. To understand the molecular basis and medical importance of selected humoral and cellular primary immunodeficiency syndromes.

2. To understand contemporary research approaches to investigate the molecular mechanisms that underlie primary immunodeficiencies, with specific examples from recent discoveries.

3. To understand the range of disorders associated with acquired immunodeficiency syndrome, focussing on ageing, pregnancy, nutritional deficiency, HIV infection and iatrogenic causes such as bone marrow transplantation or immunosuppressive medication.

4. To explore how the study of mechanisms for immunodeficiency provide new insights into normal immunology and opportunities to modulate immune responses for therapeutic applications.

5. To obtain an overview of therapies that target the immune system, including biological agents, T cell or DC therapies and advances in vaccination.

The module is assessed by an unseen final examination (80%) and a coursework essay (20%).

Module Lead: Dr Mahdad Noursadeghi

Student feedback:

I have learned so much in this module. I think more people should choose this module. Well maybe not...the size of the group is a good size, where everyone can participate.

I did enjoy this module a lot and am really glad for having chosen it. I found the topics covered particularly interesting content-wise, most lecturers were driven, during some lectures students got really involved. I think it was a particularly genuine module.

INIM3006 Allergy, Autoimmunity & Transplantation

(Term 2, Common Timetable Block E, Wednesdays 11.00 - 13.00 and Fridays: 9.00 - 11.00)

This module focuses on disadvantageous immune responses: when the immune system causes disease by mounting undesired responses to allergens, self or transplanted tissues. We will explore the genetics and immune mechanisms underlying these responses and ask why substantial numbers of individuals react in a harmful way to normally ‘harmless’ environmental antigens such as pollens or food. We will consider autoimmunity: the breakdown in the immunological tolerance mechanisms that normally prevent pathogenic responses against our own body constituents. Organ-specific and systemic autoimmune conditions will be covered and the contribution of the various components of the immune system to the destructive process discussed. We will also explore the artificial situation of transplanting an organ or tissue from one individual to another. In addition to looking into the various immunological mechanisms involved in transplant rejection, we will investigate how transplant survival can be further improved and whether the current need for long term immunosuppression after transplantation can be overcome.

The module is assessed by an unseen final examination (80%) and a coursework essay (20%).

Module Lead: Dr Benedict Seddon

Student feedback:

The range of lectures was broad and very interesting, the module itself was well organised and the sequence of lectures "flowed" well. The problem solving exercise was very helpful.

I thought a lot of the content was very interesting, lecturers were often really prominent in their fields and seemed enthusiastic about what they were teaching.

One of the best lectures I have ever had: engaging and covered interesting and relevant topics. I am now genuinely considering specialising in one of the fields.

Each component of the module was proportionally taught I felt (i.e. allergy lectures, autoimmunity lectures AND transplantation lectures).

Integrated teaching of autoimmunity, allergy and transplantation.

INIM3007 Viruses & Disease

(Term 2, Common Timetable Block C, Mondays: 11.00 - 13.00 and Wednesdays: 9.00 - 11.00)

What are viruses? How do they replicate? Where do they come from? How do they enter the human population? How do they cause disease? Why do they cause epidemics? Why are some viruses much more dangerous than others? How do we control and prevent infections? This module will address these questions by exploring the remarkable and intimate interaction between virus and host at many levels: molecular, cellular, host organism and population. We will discover how viruses have adapted to optimise survival and replication in the fundamentally hostile environment that their host provides and we will discuss the many effector mechanisms that hosts deploy to prevent viral infection or control it once established.

The module is centred on the idea that an understanding of basic virology is essential for understanding viral disease. Drawing on a major strength in experimental and clinical virology at UCL, the module will provide an advanced understanding of the principles of virus replication and structure, insight into the virus-host interaction and a broad knowledge of individual virus infections, their treatment and prevention.

The module is assessed by an unseen final examination (80%) and a paper presentation (20%).

Module Lead: Dr Richard Milne

Student feedback:

Interesting, current, relevant, wide range of viruses covered (but not too many that it was overwhelming!), all lecturers were fantastic, obviously passionate about their subject. Paper presentations were a good way too assess understanding and were fun to create. Great module.

I really enjoyed having such a diverse array of inspiring lectures who were really passionate about their topic.

I really enjoyed the wide range of topics covered within virology and the focus on both research and clinical practice. Also, it was a pleasure to be taught by a number of different lecturers at the top of their field.

There were clear themes and aims which all the lectures seemed relevant too.

It was very well organised, with an good range of highly relevant topics covered. The lectures themselves were excellent, and pitched at an appropriate level of complexity. Overall - fab.

Pitched at a challenging level, yet in a way that we were able to follow.

Favourite module of the 3 years I've done here!

INIM3008 Microbial Pathogenesis

(Term 2, Common Timetable Block A, Mondays: 9.00 - 11.00 and Thursdays: 11.00 - 13.00)

This module will explore how bacteria of clinical and public health importance interact with their human host, cause disease, and how they can be treated and prevented. The module will introduce general concepts and use selected examples of bacteria that have special niches (intracellular / extracellular) and that infect distinct tissues (e.g. brain; lung and the gut). We will also introduce new molecular and cellular techniques that are being used to probe interactions between bacteria and their hosts. We will explore the impact of antimicrobial resistance on bacteria and their hosts. Finally, we will show how new knowledge of cellular bacteriology, and bacterial and human genomes is being used in development of novel anti-bacterial treatments and prevention strategies.

This module will consist of a series of state-of-the-art lectures given by leaders in their fields followed by a journal club focused on a high impact paper relevant to the previous lecture led by post-doctoral scientists.

The module is assessed by an unseen final examination (70%), an elevator pitch (20%) and a commentary (10%).

Module Lead: Professor Rob Heyderman

INIM3009 Neoplasia & its Treatment

(Term 2, Common Timetable Block D, Tuesday 11.00 - 13.00 and Thursday 9.00 - 11.00)

This module explores the processes and molecular mechanisms that underpin neoplastic transformation, tumour invasion and metastasis, with reference to specific haematological and solid tumours.

The aim is for the student to build on an assumed core knowledge of cell and molecular biology to understand the natural history of neoplastic disease. There is considerable emphasis on the links between normal growth, development and responsiveness, and neoplastic growth. Site specific aspects of neoplasia (e.g. colon cancer, lung cancer and leukaemia) will be considered. In addition, all these topics will be linked to lectures that explore the mechanisms of current and novel treatment modalities including chemotherapy, biologicals, stem cell transplantation, immunotherapy and gene therapy.

The module starts with an overview of current concepts of normal and abnormal growth, cancer stem cells, cell senescence and immortalisation, invasion and metastasis. We then examine cell transformation at a cellular and molecular level and look at DNA damage and repair mechanisms. The properties of the neoplastic cell are examined critically, looking at oncogenes, growth factors and their receptors and there will be a discussion about chromosome abnormalities in cancer. The link between viral infections and human tumours and the biology of oncogenic viruses and their relationship with the immune system will be explored. To put neoplastic disease in its societal context, epidemiological aspects will be covered in a separate session. There will be lectures on stem cells –an increasingly important topic, not only in our understanding of the basic science of neoplasia, but also with important therapeutic implications.

Malignant tumours are the second most common form of illness leading to death in this country. Treatments include surgery, radiotherapy, hormones and various forms of cytotoxic chemotherapy. The second part of the module will look at the mechanisms which underlie some of these forms of treatment including the molecular basis of anti-cancer drugs and the use of radiation and its effects. We will cover the basic principles of tumour immunity and the potential of immune mechanisms in the prevention, limitation and evolution of tumours. Physical and chemical oncogenic agents or carcinogens have a more subtle relationship with the immune system, and this will be explored. Lastly, the possibility of manipulating immunogenic tumours to the benefit of the individual or of using immunological weapons to attack malignant tumours will be explored, giving an insight into cancer therapies of the future; and this leads into a discussion of the potential advantages and disadvantages of gene therapy for cancer.

The module is assessed by an unseen final examination (80%) and a coursework essay (20%).

Module Lead: Dr Clare Bennett

Student feedback:

Good exposure to latest development in cancer immunology research.

Good balance of science and clinical lectures.

I liked that it covered a broad range of different neoplasias/cancer. It also covered all aspects of the disease, cause, progression treatment etc. I also liked the fact that the information we were receiving was current and relevant, for example the new mABs etc that are being developed currently. I like the structure of the module and the chronology of it works well.

I like that a range of areas were covered starting from cell cycle, looking at how drugs works, then onto biological pathways involved in some cancers. As it is under a immunology code, I'm glad a lot of the lectures were looking at targeting the immune system.

Page last modified on 16 aug 17 17:25