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Division of Infection and Immunity

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Dr Siobhan Burns

Reader in Immunology

About

Research in Dr Siobhan Burns' lab focusses on primary immunodeficiency disorders.

Research summary

Primary Immunodeficiency Disorders (PID) are inherited conditions where specific components of the immune system are missing or defective. This results in severe and frequent infections, often accompanied by autoimmunity and inflammation.

Our group is focused on understanding the underlying molecular and cellular mechanisms that give rise to PID. We have a particular interest in how genetic mutations associated with PID impact the function of immune cells, particularly innate immune cells, such as neutrophils and dendritic cells.

We utilise a number of experimental approaches to examine immune cell function including human blood cells, cell line models of PID generated through targeted silencing of immune genes and murine models of PID.

Our work closely collaborates with national research aimed at identifying the genes that cause PID. We are developing deep phenotyping and functional assays to compliment genetic analysis and improve our ability to identify patients suitable for tailored therapies.

Selected publications

A full list of publications can be accessed via PubMed.