Dr Gabriele Pollara
Wellcome Trust Postdoctoral Clinical Research Fellow
NIHR Clinical Lecturer
The Pollara Lab investigate human immune responses to tuberculosis infection and improving analysis of whole genome transcriptional data.
My work touches on two core themes, namely investigating human immune responses to tuberculosis infection and improving comparative analysis of whole genome transcriptional data. I have focused particularly on the use of transcriptional modules (a.k.a. signatures) to deconvolute biological information from multicellular transcriptional datasets, developing software that ranks modules based on their sensitivity and specificity for their annotated functions.
My clinical training specialty is in Infectious Diseases & Microbiology, and during this time I developed an interest in better understanding immunity to tuberculosis, a pathogen that has circulated in the human population for centuries, and yet still has a significant impact on morbidity and mortality worldwide.
In 2013 I was awarded a Wellcome Trust Postdoctoral Clinical Research Fellowship to study correlates of protection to tuberculosis, making use of both human in vivo challenge models and in vitro models of macrophage-tuberculosis interaction. The project was largely based in the laboratory of Professor Mahdad Noursadeghi (UCL) and involved recruitment of individuals infected with tuberculosis both in the UK and in Peru, in collaboration with Professor David Moore (London School of Hygiene and Tropical Medicine).
I am now a NIHR Clinical Lecturer in Medical Microbiology at UCL, bringing together the observations made in my Postdoctoral Fellowship to workup future studies that aim to harness knowledge of the host immune response in tuberculosis infections to generate novel host-directed therapies.
- Byng-Maddick R, Turner CT, Pollara G, Ellis M, Guppy NJ, Bell LCK, Ehrenstein MR, Noursadeghi M. Tumor Necrosis Factor (TNF) Bioactivity at the Site of an Acute Cell-Mediated Immune Response Is Preserved in Rheumatoid Arthritis Patients Responding to Anti-TNF Therapy. Front Immunol. 2017;4;8:932
- Pollara G, Bali S, Marks M, Bates I, Collier S, Balakrishnan I. Time Efficiency Assessment of Antimicrobial Stewardship Strategies. Clin Infect Dis. 2017;15;64(10):1463-1464
- Pollara G, Murray MJ, Heather JM, Byng-Maddick R, Guppy N, Ellis M, Turner CT, Chain BM, Noursadeghi M. Validation of Immune Cell Modules in Multicellular Transcriptomic Data. PLoS One. 2017;12(1):e0169271
- Pollara G, Marks M. Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Abscess. N Engl J Med. 2016;21;375(3):285
- Panesar P, Jones A, Aldous A, Kranzer K, Halpin E, Fifer H, Macrae B, Curtis C, Pollara G. Attitudes and Behaviours to Antimicrobial Prescribing following Introduction of a Smartphone App. PLoS One. 2016;11(4):e0154202
- Haas CT, Roe JK, Pollara G, Mehta M, Noursadeghi M. Diagnostic 'omics' for active tuberculosis. BMC Med. 2016;23;14:37
- Bell LC, Pollara G, Pascoe M, Tomlinson GS, Lehloenya RJ, Roe J, Meldau R, Miller RF, Ramsay A, Chain BM, Dheda K, Noursadeghi M. In Vivo Molecular Dissection of the Effects of HIV-1 in Active Tuberculosis. PLoS Pathog. 2016;17;12(3):e1005469
- Marks M, Pollara G. Short-Course Antimicrobial Therapy for Intraabdominal Infection. N Engl J Med. 2015;373(16):1577
- Pollara G, Marks M. Treatment of Uncomplicated Acute Appendicitis. JAMA. 2015;6;314(13):1402
- Marks M, Pollara G, Miller D, Bhatt S, Reynolds C, Gant V, Noursadeghi M. elCID: An electronic Clinical Infection Database to support integrated clinical services and research in infectious diseases. J Infect. 2015;71(3):402-405.
A full list of publications can be accessed via PubMed.