Selected Papers

H2AX+CD8+ T lymphocytes cannot respond to IFN-α, IL-2 or IL-6 in chronic hepatitis C virus infection
Hoare M, Shankar A, Shah M, Rushbrook S, Gelson W, Davies S, Akbar A, Alexander GJ
Journal/Ref: J Hepatol. 2013 May;58(5):868-74

Insertional Mutagenesis by Retroviral Vectors: Current Concepts and Methods of Analysis
Knight S, Collins M, Takeuchi Y
Journal/Ref: Curr Gene Ther. Volume 13, Number 3, June 2013 , pp. 211-227(17)

Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4(+) T lymphocytes
Comandini A, Naro C, Adamo R, Akbar AN, Lanna A, Bonmassar E, Franzese O
Journal/Ref: Mol Immunol. 2013 Jun;54(2):181-92

Age-Associated Increase of Low-Avidity Cytomegalovirus-Specific CD8+ T Cells That Re-Express CD45RA
Griffiths SJ, Riddell NE, Masters J, Libri V, Henson SM, Wertheimer A, Wallace D, Sims S, Rivino L, Larbi A, Kemeny DM, Nikolich-Zugich J, Kern F, Klenerman P, Emery VC, Akbar AN
Journal/Ref: J Immunol. 2013 Jun 1;190(11):5363-5372

Investigation of the Cutaneous Response to Recall Antigen in Humans in vivo
Akbar A, Reed J, Lacy K, Jackson S, Vukmanovic-Stejic M, Rustin M
Journal/Ref: Clin Exp Immunol. 2013 Mar 27

The "silent" global burden of congenital cytomegalovirus
Manicklal S, Emery VC, Lazzarotto T, Boppana SB, Gupta RK
Clin Microbiol Rev. 2013 Jan;26(1):86-102. doi: 10.1128/CMR.00062-12

T-bet and GATA3 orchestrate Th1 and Th2 cell differentiation through lineage-specific targeting of distal regulatory elements
Kanhere A., Hertweck A., Bhatia U., Gokmen R., Perucha, E., Jackson I., Lord G.M., and Jenner R.G
Nature Communications. 3:1268 (2012)

Genome-wide analyses of Zta binding to the Epstein Barr Virus genome reveals interactions in both early and late lytic cycle and an epigenetic switch leading to an altered binding profile
Ramasubramanyan S, Kanhere A, Osborn K, Flower K, Jenner RG, Sinclair AJ
J Virol. 2012 Sep 26

Bistable collective behavior of polymers tethered in a nanopore
Osmanovic, D, Bailey, J, Harker, AH, Fassati, A, Hoogenboom, BW, Ford, IJ
Phys. Rev. E  2012 Jun;85(6-1):061917. Epub 2012 Jun 21

Hyperthermia stimulates HIV-1 replication
Roesch, F, Meziane, O, Kula, A, Nisole, S, Porrot, F, Anderson, I, Mammano, F, Fassati, A, Marcello, A, Benkirane, M, Schwartz, O
PLoS Pathogens 2012 Jul;8(7):e1002792. Epub 2012 Jul 12

Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization McCoy LE, Quigley AF, Strokappe NM, Bulmer-Thomas B, Seaman MS, Mortier D, Rutten L, Chander N, Edwards CJ, Ketteler R, Davis D, Verrips T, Weiss RA
J Exp Med. 2012 Jun 4;209(6):1091-103. Epub 2012 May 28. PMID: 22641382

Diversity of TRIM5alpha and TRIMCyp sequences in cynomolgus macaques from different geographical origins
Berry, N. J., F. Marzetta, G. J. Towers, and N. J. Rose
Immunogenetics. 2012 Apr;64(4):267-78. Epub 2011 Nov 29

IFITM3 restricts the morbidity and mortality associated with influenza.
Everitt AR...Kellam P et al
Nature. 2012 Mar 25. doi: 10.1038/nature10921. [Epub ahead of print]

Diverse HIV viruses are targeted by a conformationally dynamic antiviral
Caines, M. E., K. Bichel, A. J. Price, W. A. McEwan, G. J. Towers, B. J. Willett, S. M. Freund, and L. C. James
Nat Struct Mol Biol. 2012 Mar 11;19(4):411-6

Innate immune interferon responses to Human immunodeficiency virus-1 infection
Hughes, R., G. Towers, and M. Noursadeghi
Rev Med Virol. 2012 Feb 22

Specific capture and whole-genome sequencing of viruses from clinical samples.
Depledge DP, Palser AL, Watson SJ, Lai IY, Gray ER, Grant P, Kanda RK, Leproust E, Kellam P, Breuer J
PLoS One. 2012;7(1). doi: 10.1371/annotation/3f1444bc-ab9d-4112-958a-2e068792f26f. Epub 2012 Jan 24

HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency.
Schaller T, Ocwieja KE, Rasaiyaah J, Price AJ, Brady TL, Roth SL, Hué S, Fletcher AJ, Lee K, Kewalramani VN, Noursadeghi M, Jenner RG, James LC, Bushman FD, Towers GJ
PLoS Pathog. 2011 Dec;7(12):e1002439. Epub 2011 Dec 8

HIV-1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef
Sauter, D., Hue, S., Petit, S. J., Plantier, J. C., Towers, G. J., Kirchhoff F., Gupta, R.K
Retrovirology. 2011 Dec 15;8:103

Phylogenetic analysis of murine leukemia virus sequences from longitudinally sampled chronic fatigue syndrome patients suggests PCR contamination rather than viral evolution
Katzourakis, A., S. Hue, P. Kellam, and G. J. Towers. 2011
J. Virol 85:10909-10913

Analysis of the HIV-1 M group Vpu domains involved in antagonizing tetherin (BST-2)
Petit, S. J., C. Blondeau, and G. J. Towers. 2011
J Gen Virol in press

Transportin 3 Promotes a Nuclear Maturation Step Required for Efficient HIV-1 Integration
Lihong Zhou, Elena Sokolskaja, Clare Jolly, William James, Sally A. Cowley, Ariberto Fassati
PLoS Pathog. 2011 Aug;7(8):e1002194. Epub 2011 Aug 25

Early potent protection against heterologous SIVsmE660 challenge following live attenuated SIV vaccination in Mauritian cynomolgus macaques
Berry, N., C. Ham, E. T. Mee, N. J. Rose, G. Mattiuzzo, A. Jenkins, M. Page, W. Elsley, M. Robinson, D. Smith, D. Ferguson, G. Towers, N. Almond, and R. Stebbings
PLoS One. 2011;6(8):e23092. Epub 2011 Aug 10

PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8(+) T cells.
Karwacz K, Bricogne C, Macdonald D, Arce F, Bennett CL, Collins M, Escors D.
EMBO Mol Med. 2011 Jul 8. doi: 10.1002/emmm.201100165. [Epub ahead of print]
PMID: 21739608 [PubMed - as supplied by publisher]

Feline tetherin efficiently restricts release of feline immunodeficiency virus but not spreading of infection
Dietrich I., McMonagle E. L., Petit S. J., Vijayakrishnan S., Logan N., Chan C. N., Towers G. J., Hosie M. J. and B. J. Willett
J Virol. 2011 Jun;85(12):5840-52. Epub 2011 Apr 13

No Evidence of XMRV or Related Retroviruses in a London HIV-1-Positive Patient Cohort
Gray ER, Garson JA, Breuer J, Edwards S, Kellam P, Pillay D, and G.J. Towers
PLoS One. 2011 Mar 23;6(3):e18096

No Evidence of XMRV in Prostate Cancer Cohorts in the Midwestern United States
Sakuma T, Hue S, Squillace KA, Tonne JM, Blackburn PR, Ohmine S, Thatava T, Towers GJ, and Y. Ikeda
Retrovirology. 2011 Mar 29;8:23

HIV Integration Targeting: A Pathway Involving Transportin-3 and the Nuclear Pore Protein RanBP2
Ocwieja, K. E., T. L. Brady, K. Ronen, A. Huegel, S. L. Roth, T. Schaller, L. C. James, G. J. Towers, J. A. Young, S. K. Chanda, R. Konig, N. Malani, C. C. Berry, and F. D. Bushman
PLoS Pathog. 2011 Mar;7(3):e1001313. Epub 2011 Mar 10

Disease-associated XMRV sequences are consistent with laboratory contamination.
Hué S, Gray ER, Gall A, Katzourakis A, Tan CP, Houldcroft CJ, McLaren S, Pillay D, Futreal A, Garson JA, Pybus OG, Kellam P, Towers GJ.
Retrovirology. 2010 Dec 20;7(1):111

Gyrase B inhibitor impairs HIV-1 replication by targeting Hsp90 and the capsid protein.
Vozzolo L, Loh B, Gane PJ, Tribak M, Zhou L, Anderson I, Nyakatura E, Jenner RG, Selwood D, Fassati A.
J Biol Chem. 2010 Dec 10;285(50):39314-28. Epub 2010 Oct 11

Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity.
Ylinen LM, Price AJ, Rasaiyaah J, Hué S, Rose NJ, Marzetta F, James LC, Towers GJ.
PLoS Pathog. 2010 Aug 19;6(8). pii: e1001062

Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome.
Bagnéris C, Ageichik AV, Cronin N, Wallace B, Collins M, Boshoff C, Waksman G, Barrett T.
Mol Cell. 2008 Jun 6;30(5):620-31

Targeting dendritic cell signaling to regulate the response to immunization.
Escors D, Lopes L, Lin R, Hiscott J, Akira S, Davis RJ, Collins MK.
Blood. 2008 Mar 15;111(6):3050-61. Epub 2008 Jan 7

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