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Robin Weiss: Election to US National Academy of Sciences

Congratulations are offered to Professor Robin Weiss on his election to the National Academy of Sciences (USA). Robin is Emeritus Professor of Viral Oncology in the Wohl Virion Centre. (Link to Wohl)
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Published: Jun 5, 2013 10:30:40 AM

COMING UP: MRC@UCL Centenary Science Fair

The MRC@UCL Centenary Science Fair will be a family fun day for all ages and will include lab tours, talks, hands-on activities, interactive demonstrations, games and exhibitions. There will be stalls and exhibits in the UCL Cloisters off the main quad, and a treasure hunt for younger visitors. Some of the groups involved and activities planned include: The Centre for Medical Molecular Virology will run science workshops offering a fun, hands-on experience of what the centre does. Including DNA extraction, testing pipetting skills and allowing visitors to demonstrate creative flair by designing and drawing their own interpretations of viruses. The Unit for Lifelong Health and Ageing will exhibit research findings about the National Survey of Health and Development (NHSD), alongside a timeline of public interest milestones. They will also host a variety of activities, including testing grip strength and measuring reaction times.  Students from the Laboratory for Molecular Cell Biology will show what it's like to work in a lab, with various interactive presentations and demonstrations, and the opportunity to discuss careers in medical research. The MRC fellows at UCL will give a series of talks aimed at the general public highlighting the biomedical research funded by the MRC. These talks will focus on the big challenges in biomedical research including cancer, heart disease, infections and diseases of the nervous system. The Seminar series will be officially started by Nobel laureate and one of the BBC's 'Beautiful Minds', Sir Tim Hunt In addition, visitors can sign up for visits to the research labs at the Laboratory for Molecular Cell Biology. More...

Published: Mar 5, 2013 1:42:56 PM

Programme 2: Viral Genome Associations with Disease


Identifying viral genetic determinants of disease outcome, transmission and resistance


Programme Co-ordinator: Prof Judy Breuer

DNA helix

The wealth of clinically and biologically phenotyped samples available within UCL Biobanks, coupled with exciting new developments in our next-generation sequencing facility, will allow us to identify genetic determinants of disease outcome, transmission and drug resistance. For the first time whole genome sequencing of low copy viral DNA isolated from clinical samples is now possible. Programme research at the Centre is now concentrating on applying these methods to:

  • Screen whole viral genomes for single nucleotide polymorphisms (SNPs) associated with disease development or recovery in patients
  • Tailor existing treatments to target disease developments based on SNP associations
  • Develop new drugs based on novel disease associated SNP sites
cryotubes

BIOBANKING FACILITIES

The development of biobank facilities at UCL is key to furthering research of this nature. Using residual diagnostic samples, initial studies will look at screening for disease associated SNPs in HSV, VZV and EBV. It is envisioned that genetic association studies will encompass a much larger variety of disease states associated with HIV, etc. In addition to the biobanks already housed at the Royal Free campus, a new satellite bank within the Centre is currently in development. Working closely with UCL Hospitals and Great Ormond Street Hospital volunteer and residual diagnostic samples of blood, CSF, and other tissues from patients in varying states of disease development will be collected. It is anticipated that in the long term collections will also be sourced from across the UK and Europe.

SPECIFIC PROJECTS

  • Development of whole genome sequencing of low copy viral DNA from clinical samples
  • Identification of neurotropic variants of herpes simplex and varicella zoster virus
  • Identification of genomic polymorphisms in EBV associated with the development of lymphoma in immune deficient and post-organ transplant children

PEOPLE

Aasa-Chapman, Marlen

Atkinson, Claire

Breuer, Prof Judy

Collins, Lauren

Depledge, Dr Daniel

Emery, Prof Vince

Gray, Dr Eleanor

Griffiths, Prof Paul

Gupta, Dr Ravindra

Hue, Dr Stephane

Kellam, Prof Paul

Lange, Camille

Lai, Imogen

Milne, Dr Richard

Pillay, Prof Deenan

Simpson, Dr Nandi

Page last modified on 22 jun 12 11:41 by Lauren J Collins