IIT Virtual Seminar | Dr Rahul Roychoudhuri
29 October 2020, 12:00 pm–1:00 pm
'Stemness and memory within the regulatory T cell lineage'
Dr Anne Pesenacker
Dr Rahul Roychoudhuri (Babraham Institute) will be speaking at the UCL Institute of Immunity and Transplantation Seminar Series on Thursday 29 October. The seminar will be held virtually over Microsoft Teams.
All are welcome to attend. Please contact Fran Jackson (firstname.lastname@example.org) if you would like to join the seminar, or meet the speaker.
About the speaker
T cells drive immune activation and promote clearance of infections and cancer. However, their function can also provoke autoimmune and allergic inflammation. The immune system therefore employs a variety of suppressive mechanisms, known as immunoregulatory mechanisms, to restrain excessive T cell activation that would otherwise cause deleterious inflammation, or immunopathology following infection. Immunoregulatory mechanisms also suppress beneficial T cell responses against cancer, resulting in deleterious immunosuppression. Immunoregulatory mechanisms therefore function as ‘brakes’ on immune activation and have important consequences in infection, inflammation and cancer.
Research in the Roychoudhuri Lab aims to uncover the molecular and cellular mechanisms underpinning immunoregulation and cancer immunosuppression. Fundamental discovery in the field of immunoregulation will pave the way for new therapies aimed at manipulating immune function in patients with autoimmunity and cancer.
The laboratory uses cutting-edge molecular immunology, functional genomics and mouse genetics to enable discovery of novel host immunoregulatory mechanisms (see Research). The Roychoudhuri Lab has a particular interest in the immunoregulatory mechanisms that control the differentiation and function of CD4+ and CD8+ conventional T cells and Foxp3+ regulatory T (Treg) cells.
For more information please see: http://roychoudhurilab.org/member/rahul