IIT Seminar | Dr Louise Boyle
18 October 2018, 12:00 pm–1:00 pm
'A novel way to manipulate peptide presentation on cell surface MHC class I molecules'
Dr Victoria Male (Host)
Tutorial Room 14UCL Medical School, Royal Free CampusRowland Hill StreetLondonNW3 2QGUnited Kingdom
Dr Louise Boyle of the Department of Pathology at the University of Cambridge will be speaking at the UCL Institute of Immunity and Transplantation Seminar Series on Thursday 18 October. The seminar will be held in Tutorial Room 14 at the UCL Medical School Royal Free Campus.
Dr Boyle is interested in determining the molecular mechanisms controlling peptide selection by MHC class I molecules. This is an important problem, giving the role of MHC class I molecules in infectious diseases, cancer and autoimmunity. Initially, tapasin was thought to be the only MHC class I-specific chaperone in the antigen processing and presentation pathway, and was therefore considered to be the key molecule controlling peptide presentation. Recently, the Boyle lab has discovered a completely movel MHC class I-specific component in the antigen processing and presentation pathway: a protein called TAPBPR, which shares the same MHC class I binding site as tapasin. This implicates TAPBPR in peptide selection, suggesting the current model of antigen presentation by class I is incomplete.
All are welcome to attend. If you would like to meet the speaker after the seminar please contact the host.