Institute of Immunity and Transplantation


Paul Griffiths

Professor of Virology

Research area

Herpesviruses, vaccination, and virus infection of the immunocompromised host.

Research programme

Research summary

My research concerns quantitative aspects of the natural history and pathogenesis of herpesvirus infections, especially cytomegalovirus in immunocompromised renal, or liver transplant patients, in addition to the potential interactions between herpesviruses and HIV.

My interests are in the design of, and results from controlled clinical trials of compounds or vaccines active against herpesviruses, which when used as probes of pathogenesis may reveal the full spectrum of diseases caused or triggered by these common infectious agents.

My group completed a Phase II trial into a novel vaccine for cytomegalovirus with positive results and our current research aims to identify immune correlates of protection. I am now in the process of advising on the design of alternate vaccine trials for cytomegalovirus.

Patient involvement

We advise individual patients about their risks of CMV, particularly pregnant women and the parents of children with sensorineural hearing loss.

We encourage transplant patients to enter into randomised controlled trials or natural history studies to help us understand CMV itself and how it may be controlled. Currently, a five-year natural history study using whole genomic sequencing and specialist immunology is underway in transplant patients at the Royal Free. This is funded by a grant from the Wellcome Trust and is done in collaboration with colleagues in Cambridge, Cardiff and Glasgow universities.


Selected publications
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