New state-of-the-art centre for immune disease opens

This week researchers completed their move into the Pears Building, Hampstead, which is a collaboration between UCL, the Royal Free Charity, and the Royal Free London NHS Foundation Trust (RFL).

The cutting-edge facility is the new home of the UCL Institute of Immunity and Transplantation and unites the world-leading scientists with the expertise of clinicians at the RFL. It increases the likelihood that patients with immune-related conditions will soon be able to access groundbreaking therapies unavailable anywhere else.

The £60m institute will not only bring the theory and implementation of research much closer together but will also allow the public easy access to the latest discoveries in immunology research.

Based in the grounds of the Royal Free Hospital, the building will accommodate up to 200 researchers who have been moving in over the past month. Patients taking part in research will be offered accommodation on the top floors of the building, many with stunning views across Hampstead Heath.

Professor Hans Stauss, Director of UCL Institute of Immunity and Transplantation, said: “The UCL IIT is dedicated to the patient-focused research of the human immune system.

“The facilities in the new building will help us develop treatments to ‘turn up’ the immune system to respond to a threat from, say, a coronavirus, or to recognise cancer cells as a danger. We also explore ‘turning down’ the immune system in order to stop the rejection of transplanted organs and to treat autoimmune diseases such as type 1 diabetes, rheumatoid arthritis and multiple sclerosis.

“The final cluster of our research is around different inherited conditions, such as primary immunodeficiencies, in which faulty genes affect how the body’s immune system works.”

Professor Stauss said that the co-location of scientists and clinicians within the Pears Building meant that information discovered in the laboratory could be used to work with doctors, nurses and other healthcare professionals to refine and improve further research.

“The clinical trial facilities will help to accelerate the translation of scientific discoveries into new therapies for patients and I fully expect patients to be able to access cutting edge therapies not available elsewhere,” he added.

Pradip Patel, who lives in Southgate, north London, is hoping research being carried out at the UCL IIT could transform outcomes for patients like him in the future.

In 2017, Pradip had a kidney transplant at the Royal Free Hospital – a childhood infection had scarred his kidneys so by his late 50s they had stopped working properly. The surgery went well but a couple of days later Pradip began experiencing severe stomach pains. Pradip’s immune system saw the new kidney as a ‘foreign object’ and had started attacking it. This is known as graft rejection and is a recognised risk to patients following a transplant operation.

Pradip had to undergo two further operations in the space of a few days and was given powerful drugs to suppress his immune system, as well as dialysis to ensure waste products would continue to be removed from his bloodstream until the new kidney started working properly. After recovering his health, Pradip was determined to help the doctors who had transformed his life and organised a charity golf event which raised £16,000 which was donated to the institute.

Reza Motallebzadeh, Associate Professor at UCL, is one of the researchers looking for ways to prevent graft rejection in transplant patients. His work focuses on microorganisms in the gut, known as the microbiome, which is linked to the behaviour of the immune system.

He said: “We know that the gut microbiome plays an important role in regulating the immune system, but we want to understand more about what it does in relation to influencing the immune response to a kidney transplant. Our aim is to discover whether we might be able to alter the microbiome to decrease the chance of graft rejection.

“With the UCL IIT next door to the Royal Free Hospital, it means researchers and clinicians can work closely together and with patients to ensure our research can lead to new treatments more quickly and can reap the greatest benefits to patients.”

Pradip, who lives in Southgate, north London, added: “After having three operations in a short period of time, it took me months to recover. After recovering my health I was determined to help in some way. If we can stop graft rejection happening to other patients that would be a really positive step forward.”

Caroline Clarke, Royal Free London group chief executive, highlighted the benefits to patients of the UCL IIT’s new home. “Our expansion of the institute will give many more of our patients the opportunity to take part in groundbreaking research.

“As well as providing more space for scientists to develop better treatments for cancer, diabetes, HIV and tuberculosis, and to support transplantation, the new centre will play its part in crucial research into COVID-19, helping the international effort to tackle this devastating virus. This important work will not only contribute to the health and wellbeing of our local community but will also be a world-leading centre for understanding the human immune system.”

The building also has offices for the Royal Free Charity and a 71-space car park for patients and visitors. It has been designed to complement the local area, with set-back terraces on the upper levels which allow light into the spaces behind the building. 

Jon Spiers, chief executive of the Royal Free Charity, said: “The huge generosity of our donors, particularly the Pears Foundation, is what has made this unique collaboration possible and we are deeply grateful to them for helping us to bring so much hope to patients here and across the world.”

Links

• The Pears Building
• Royal Free Charity
• Royal Free London NHS Foundation Trust

Image

The Pears Building. Credit: Janie Airey Hopkins.

Further information

• Source: Adapted from the Royal Free Hospital
• Media Contact: Henry Killworth, Tel: +44 (0) 7881 833274

The drug will be trialled on patients with NHL subtypes, including relapsed/refractory chronic lymphocytic leukaemia (CLL) / small lymphocytic lymphoma (SLL) and mantle cell lymphoma (MCL).

This multi-centre trial, sponsored and funded by NovalGen Limited, a UCL spinout company, will be taking place at various centres in the UK including UCLH.

Professor Nathwani, who is also founder and Chief Executive of NovalGen, said: “The dosing of our first patient marks a significant milestone for NovalGen.

“NVG-111 is our first clinical programme for patients with chronic lymphocytic leukemia and mantle cell lymphoma.

“We are developing bispecific therapies that can safely harness the immune system to treat both hematologic malignancies and solid tumors and have an exciting pipeline of products in development.”

NHL usually originates in lymphoid tissues (cells and organs important in the immune response, including bone marrow, thymus, and lymph nodes) and the incidence increases with age. Options for chemotherapy-resistant patients currently remain limited and new therapies are needed.

NVG-111 is a first-in-class bispecific antibody T-cell engager which is designed to be effective in the killing of cancer cells without affecting healthy immune cells. In preclinical studies, NVG-111 showed efficacy in a range of hard-to-treat blood cancers as well as solid tumours.

The trial will be conducted in two parts: In Part A, sequential doses will be tested to identify ‘dose limiting toxicities’ (DLTs) and used to decide dose - to be studied; Part B will include one cohort of patients with CLL/SLL and one with MCL to further assess the efficacy and safety profile of NVG-111.

The maximum duration of participation for each patient is up to 32 months. This includes up to a four week screening period, a treatment period of up to six cycles, and a safety follow-up conducted four weeks after the last dose as well as up to 24 months long term follow-up.

At University College London Hospitals NHS Foundation Trust (UCLH), the trial will be led by Principal Investigator Dr William Townsend, a consultant haematologist who leads a comprehensive portfolio of early phase trials in lymphoproliferative disorders.

“I am very excited to be helping to bring this novel therapy to the CRF for the benefit of our patients. It is particularly gratifying as this drug was developed through the UCL laboratories and helps to deliver on the UCL/UCLH bench-to-bedside research vision,” he said.

The study’s Chief Investigator Dr Parag Jasani, a Consultant Haematologist at UCLH and clinical lead for CLL, said: “NVG-111 holds great promise for patients with chronic lymphocytic leukaemia and mantle cell lymphoma, which are both currently incurable conditions. Patients typically endure multiple rounds of therapy and ultimately their cancer develops resistance or transforms into an aggressive, unresponsive form.”

Links

• Academic profile: Professor Amit Nathwani
• NovalGen
• UCLB
• UCL Innovation & Enterprise
• UCLH NIHR BRC
• UCLH

Further information

• Source: UCL News
• Media Contact: Henry Killworth, Tel: +44 7881 833274