Sir Henry Dale Fellow
Viral immune evasion.
Viruses are parasites that hijack the biological machinery inside host cells and use it to replicate; this can kill cells and cause disease. Virus particles transmit infection from one cell to another; they specifically target and enter host cells to deliver their viral genomes to the cell interior and initiate infection. Antibodies are produced by the immune system to control and prevent such viral infections. Antibodies bind to the surface of virus particles and prevent them from entering host cells. Viruses exhibit a range of countermeasures that allow them to achieve virus entry despite the antibody response.
Viruses that establish persistent life-long infections, such as human immunodeficiency virus (HIV) and hepatitis C virus (HCV), are particularly good at evading immune responses. This is why it is especially difficult to design effective vaccines against these viruses. We are using HCV and HIV as model systems to understand the molecular mechanisms of antibody evasion during virus entry. We use a multidisciplinary approach, encompassing basic virology, structural biology, computational modelling and advanced microscopy. Through our work, we aim to gain a fundamental understanding of how viruses establish and maintain infection; this knowledge can be used to guide the design of novel therapies and vaccines.
- Selected publications
- Lythgoe KA, Gardner A, Pybus OG, Grove J. Short-Sighted Virus Evolution and a Germline Hypothesis for Chronic Viral Infections. Trends Microbiol. 2017;25:336-348
- Grove J, Hu K, Farquhar MJ, Goodall M, Walker L, Jamshad M, Drummer HE, Bill RM, Balfe P, McKeating JA. A new panel of epitope mapped monoclonal antibodies recognising the prototypical tetraspanin CD81. Wellcome Open Res. 2017;2:82
- Culley S, Towers GJ, Selwood DL, Henriques R, Grove J. Infection Counter: Automated Quantification of in Vitro Virus Replication by Fluorescence Microscopy. Viruses. 2016;8:pii: E201
- Grove J. Super-resolution microscopy: a virus' eye view of the cell. Viruses. 2014;6:1365-78
- Grove J, Metcalf DJ, Knight AE, Wavre-Shapton ST, Sun T, Protonotarios ED, Griffin LD, Lippincott-Schwartz J, Marsh M. Flat clathrin lattices: stable features of the plasma membrane. Mol Biol Cell. 2014;25:3581-94
- Henry AG, Hislop JN, Grove J, Thorn K, Marsh M, von Zastrow M. Regulation of endocytic clathrin dynamics by cargo ubiquitination. Dev Cell. 2012;23:519-32
- Grove J, Marsh M. The cell biology of receptor-mediated virus entry. J Cell Biol. 2011;195:1071-82
- Syder AJ, Lee H, Zeisel MB, Grove J, Soulier E, Macdonald J, Chow S, Chang J, Baumert TF, McKeating JA, McKelvy J, Wong-Staal F. Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitors. J Hepatol. 2011;54:48-55
- Brimacombe CL, Grove J, Meredith LW, Hu K, Syder AJ, Flores MV, Timpe JM, Krieger SE, Baumert TF, Tellinghuisen TL, Wong-Staal F, Balfe P, McKeating JA. Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission. J Virol. 2011;85:596-605
- Wagoner J, Negash A, Kane OJ, Martinez LE, Nahmias Y, Bourne N, Owen DM, Grove J, Brimacombe C, McKeating JA, Pécheur EI, Graf TN, Oberlies NH, Lohmann V, Cao F, Tavis JE, Polyak SJ. Multiple effects of silymarin on the hepatitis C virus lifecycle. Hepatology. 2010;51:1912-21.
- View all publications
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