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UCL Human Tissue Biobanks

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UCL Queen Square Institute of Neurology

Queen Square, London, WC1N 3BG.

TISSUE BANKS, BIOBANKS AND TISSUE COLLECTIONS   

HTA Licence Number 12198.

DI: Professor Maria Thom (m.thom@ucl.ac.uk) Telephone 020 3448 4233

  1. Queen Square Brain Bank for Neurological Disorders - PD: Dr. Zane Jaunmuktane (z.jaunmuktane@ucl.ac.uk)
  2. NeuroResource - PD: Dr. Zane Jaunmuktane.
  3. MRC Centre for Neuromuscular Diseases (MRC CNMD) Biobank London - PD: Professor Sebastian Brandner (s.brandner@ucl.ac.uk)
  4. Epilepsy Society Brain and Tissue Bank - PD: Professor Maria Thom (m.thom@ucl.ac.uk)
  5. CANDAS2 Biobank (Clinical Neurological Disease Biobank and Neurogenetics Research Study 2) - PD: Professor Huw Morris.
  6. Reta Lila Weston Institute of Neurological Studies - PD: Dr. Zane Jaunmuktane (z.jaunmuktane@ucl.ac.uk)
  7. Brain Tumour Bank - PD: Professor Sebastian Brandner (s.brandner@ucl.ac.uk)
  8. MRC Prion Unit at UCL - PD: Damian Johnson (damian.johnson@ucl.ac.uk)
  9. UK Dementia Research Institute at UCL - PD: Dr. Michael Sheridan (michael.sheridan@ucl.ac.uk)

Last Inspection Date: 26th November 2014.

 

2. NeuroResource Information: NeuroResource is a tissue bank which provides samples for molecular biology, neuroinflammation and disease marker research studies on tissue donations from patients with motor neurone disease, multiple sclerosis and cerebrovascular disease. Samples of brain, spinal cord, cerebrospinal fluid, blood and other tissues are utilized in a wide range of research techniques which focus on understanding disease pathogenesis.

This tissue bank is under the 1, Wakefield Street Satellite Site of the HTA Licence held by the UCL Queen Square Institute of Neurology, and is based in the Department of Neuroinflammation. NeuroResource is a Research Tissue Bank (RTB) which with the Queen Square Brain Bank is under the NRES Committee London-Central Ethics Approval 18/LO/0721.

PD: Dr. Zane Jaunmuktane (z.jaunmuktane@ucl.ac.uk). Contact for more information: j.newcombe@ucl.ac.uk; 020 7278 1338. Website.

 

5. CANDAS Biobank Information: (Full Title: Clinical Neurological Disease Biobank and Neurogenetics Research Study). CANDAS stores DNA, brain tissue, fibroblast cell lines, induced pluripotent cell lines, whole blood, serum, plasma and CSF from patients with neurological conditions and control subjects. Clinical data is also collected under CANDAS ethical approval. Currently, CANDAS receives samples and clinical data directly from patients and control subjects, as well as anonymised samples and data collected by collaborators and other investigators.

The samples and data held by CANDAS are used for genetic screening and research with the aim of understanding the biological basis of neurological disease so that new diagnostic tests, disease models and treatments may be developed in the future.  As a clinical and biological database CANDAS facilitates the identification of genetic factors that predispose to neurological disease, modulate disease phenotype, and are responsible for rarer forms of Mendelian disease. Serum, plasma and CSF samples are used to investigate biomarkers which may be helpful in diagnosis, prognosis, and monitoring of treatment response and disease progression.

Whole blood and DNA are stored at the UCL Institute of Neurology Neurogenetics laboratory, UCLH Neurogenetics Laboratory, Department of Clinical Neuroscience Laboratory Royal Free Hospital and/or at the European Collection of Authenticated Cell Cultures (ECACC) in Wiltshire. Biomarker samples including CSF, serum, plasma and cellular blood components are stored at the Royal Free Hospital, Leonard Wolfson Biomarker Laboratory, or UCL Institute of Neurogenetics Laboratory. Cell lines (and lymphocytes for cell line preparation) are stored at ECACC, or at the Institute of Neurology. Brain samples are stored at the Queen Square Brain Bank or in the Departments of Molecular or Clinical Neuroscience at the UCL Institute of Neurology. Relevant samples are stored under the UCL Institute of Neurology Human Tissue Act Licence. 

The CANDAS biobank was set up to facilitate the work of Professor Morris’ group and is not an open access resource. Members of Professor Morris’ group and collaborators may apply for permission to use samples and data in research projects which fall within the purposes outlined in the CANDAS protocol and ethical coverage. CANDAS REC reference: 19/WA/0179.
 

PD: Professor Huw Morris (h.morris@ucl.ac.uk). Contact for more information: CANDAS coordinator - ion.pdresearch@ucl.ac.uk; 020 8016 8174. Website.

 

Page updated 29-04-2021.