IHI Senior Data Scientist receives award for paper

Dr Arturo Gonzalez-Izquierdo, IHI Senior Data Scientist, has been awarded the distinguished paper award at the AMIA 2017 conference in DC, for his research paper with Zhe He from the University of Florida on methods comparing trial and EHR populations

Abstract

Clinical trials are indispensable tools for evidence-based medicine. However, they are often criticized for poor generalizability. Traditional trial generalizability assessment can only be done after the trial results are published, which compares the enrolled patients with a convenience sample of real-world patients. However, the proliferation of electronic data in clinical trial registries and clinical data warehouses offer a great opportunity to assess the generalizability during the design phase of a new trial. In this work, we compared and contrasted a priori (based on eligibility criteria) and a posteriori (based on enrolled patients) generalizability of Type 2 diabetes clinical trials. Further, we showed that comparing the study population selected by the clinical trial eligibility criteria to the real- world patient population is a good indicator of the generalizability of trials. Our findings demonstrate that the a priori generalizability of a trial is comparable to its a posteriori generalizability in identifying restrictive quantitative eligibility criteria.

Read the full story: https://amia2017.zerista.com/event/member?item_id=6377214