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UCL Institute of Health Informatics

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Nat Na-Ek

PhD Student

Institute of Health Informatics
Faculty of Population Health Sciences

Academic Backround


2015, MSc in Social Epidemiology, UCL

2009, PharmD in Pharmaceutical Care, Naresuan University

Research summary


My research focuses on: "Contributions of higher resolution observational evidence from electronic health records (EHRs) to understand the causal relevance of blood lipids".

Abstract: My PhD sets out to evaluate the causal relevance, if any, of blood lipids for common but less-well studied cardiovascular diseases, including heart failure and atrial fibrillation, as well as for a wide range of non-cardiovascular diseases, including Parkinson disease, Alzheimer’s disease, cataract, age-related macular degeneration, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, type 2 diabetes, liver cirrhosis, non-specific solid tumour, multiple sclerosis, rheumatoid arthritis, psoriasis, systemic sclerosis, and all-cause mortality in order to better understand potential efficacy and safety profiles of existing strategies to modulate lipids. The broad approach is to triangulate three forms of evidence: i. Large scale observation from a cohort (linked health records, CALIBER), ii. Available randomised trial evidence of lipid medication, and iii. Genetic evidence from Mendelian randomisation studies. Each form of evidence has strengths and weaknesses, but their synthesis where it is consistent offers a useful guide for further research efforts.

Publications


Na-Ek N, Demakakos P. Social mobility and inflammatory and metabolic markers at older ages: the English Longitudinal Study of Ageing. J Epidemiol Community Health. 2017 Mar;71(3):253-60. doi: 10.1136/jech-2016-207394. Epub 2016 Sep 19.