Department of Structural and Molecular Biology
Division of Biosciences
University College London
Darwin Building - Gower Street
WC1E 6BT London, UK
Micha Kunze
Former PhD student (Wellcome Trust)
Now PostDoc at University of Copenhagen
mbakunze[at]gmail.com
Research
Publications
PhD Project title:
Structure-Dynamics-Function Relationship of Metalloproteins: Coupling Magnetic Resonance Spectroscopy and Simulation
Research interests:
The question of how atomistic structures and motions can determine the fate of living systems is the motivator and main driving force of my research. I am especially interested in the combination of molecular dynamics simulations and nuclear magnetic resonance experiments to spatially and temporally resolve relevant protein dynamics.
Brief CV:
2010 to 2014: PhD student at the ISMB under the supervision of Dr. D Flemming Hansen, Prof. Peter V Coveney and Christopher WM Kay
2009 to 2010: Research fellow in the lab of Dr. Christopher WM Kay
2006 to 2009: BSc in physics at the University of Osnabruck , Germany. Thesis topic “EPR Spectroscopy on Spin Labelled Anthrax Lethal Factor “ in the group of Prof. Dr. H.-J. Steinhoff.
Funding:
2010 to 2014: Wellcome Trust PhD scholarship
2009 to 2010: Stipend of the German National Academic Foundation to study abroad
2006 to 2011: Scholarship of the German National Academic Foundation (Studienstiftung des deutschen Volkes)
Micha Ben Achim Kunze , David W. Wright , Nicolas Daniel Werbeck , John Kirkpatrick , Peter Vivian Coveney , and D. Flemming Hansen. Loop Interactions and Dynamics Tune the Enzymatic Activity of the Human Histone Deacetylase 8. J. Am. Chem. Soc., Just Accepted Manuscript DOI: 10.1021/ja408184x Publication Date (Web): October 30, 2013.
Balian, S. J.; Kunze, M. B. A.; Mohammady, M. H.; Morley, G. W.; Witzel, W. M.; Kay, C. W. M.; Monteiro, T. S. Measuring central-spin interaction with a spin-bath by pulsed ENDOR: Towards suppression of spin diffusion decoherence. Physical Review B 2012, 1–6.
Hansen, D. F.; Westler, W. M.; Kunze, M. B. A.; Markley, J. L.; Weinhold, F.; Led, J. J. Accurate structure and dynamics of the metal-site of paramagnetic metalloproteins from NMR parameters using natural bond orbitals. Journal of the American Chemical Society 2012, 134, 4670–82.
Valentini, S.; Cabreiro, F.; Ackerman, D.; Alam, M. M.; Kunze, M. B. A.; Kay, C. W. M.; Gems, D. Manipulation of in vivo iron levels can alter resistance to oxidative stress without affecting ageing in the nematode C. elegans. Mechanisms of Ageing and Development 2012, 133, 282–90.
Phan, G.; Remaut, H.; Wang, T.; Allen, W. J.; Pirker, K. F.; Lebedev, A.; Henderson, N. S.; Geibel, S.; Volkan, E.; Yan, J.; Kunze, M. B. A.; Pinkner, J. S.; Ford, B.; Kay, C. W. M.; Li, H.; Hultgren, S. J.; Thanassi, D. G.; Waksman, G. Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate. Nature 2011, 474, 49–53.
