Department of Structural and Molecular Biology
Division of Biosciences
University College London
Darwin Building - Gower Street
WC1E 6BT London, UK
The focus of my PhD research is primarily medicinal chemistry, based in the UCL Chemistry department with Prof. Charles Marson. I am interested in designing and synthesising novel isoform selective histone deacetylase (HDAC) inhibitors for use both as ‘tool’ compounds to help elucidate the biological functions of particular HDAC isoforms, and as future therapeutic agents with decreased toxicity.
My work in the Hansen lab mostly consists of assaying inhibitors that I have made against several purified recombinant HDAC enzymes.
2010 to 2014: Drug Discovery PhD at UCL
2006 to 2010: MChem in Chemistry at University of Oxford
"Discovery of Potent, Isoform-Selective Inhibitors of Histone Deacetylase Containing Chiral Heterocyclic Capping Groups and a N-(2-Aminophenyl)benzamide Binding Unit", Marson, C. M.; Matthews, C. J.; Yiannaki, E.; Atkinson, S. J.; Soden, P. E.; Shukla, L.; Lamadema, N.; Thomas, N. S. B. J. Med Chem 2013, 56, 6156–74.
"Discovery of a structurally novel, drug-like and potent inhibitor of peptidylarginine deiminase", Ferretti, P.; U, K. P.; Vagaska, B.; Merchant, R.; Matthews, C. J.; Marson, C. M., MedChemComm 2013, 4, 1109.
"Novel chiral skeletons for drug discovery: antibacterial tetramic acids", Holloway, C. A.; Matthews, C. J.; Jeong, Y.-C.; Moloney, M. G.; Roberts, C. F.; Yaqoob, M., Chem. Biol. Drug Des. 2011, 78, 229–35.
"Access to the Bicyclic Core of Isatisine, and an Investigation of Its Antibacterial Activity", Matthews, C.; Moloney, M.; Thompson, A.; Winiarska, H.; Winney, H., Synlett 2011, 2011, 378–382.