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Gupta Lab

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Researching host-pathogen and drug-pathogen interactions to inform HIV treatment and curative strategies.

The Gupta lab has teams in both London and at the Africa Health Research Institute in Durban South Africa. Our work focuses on two areas:

  • Studying  HIV drug resistance to protease / integrase inhibitors and implications for global scale up of antiretroviral therapy.
  • Dissecting the biology of macrophage-virus interactions given myeloid cells are parasitised by HIV and are a difficult-to-treat reservoir.

 

 

HIV-1 Remission in London patient. The Gupta lab's collaborative work is published in Nature and reported around the world: HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation. Gupta RK, Abdul-Jawad S, McCoy LE, Mok HP, Peppa D, Salgado M, Martinez-Picado J, Nijhuis M, Wensing AMJ, Lee H, Grant P, Nastouli E, Lambert J, Pace M, Salasc F, Monit C, Innes A, Muir L, Waters L, Frater J, Lever AML, Edwards SG, Gabriel IH, Olavarria E. Nature. 2019 Mar 5. doi: 10.1038/s41586-019-1027-4. [Epub ahead of print]

Prof Gupta presented the work at CROI

Prof Gupta presents 'Sustained HIV-1 Remission following homozygous CCR5 Delta32 allogenic HSCT' at CROI 2019
The Gupta Lab is funded by the Wellcome Trust Senior Research Fellowship in Clinical Science awarded to Dr Ravi Gupta.

 

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