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Drug-resistant tuberculosis is a major global health challenge, treatment remains difficult. TB-PRACETAL has been investigating three oral only drug combinations; pretomanide, linezolid and bedaquiline with or without moxifloxacin or clofazimine.
A pharmacokinetic-pharmacodynamic study was nested into TB-PRACTECAL in order to investigate the relationship between the patients’ antibiotic exposure and sterilizing effects and treatment outcome. With this information we can inform optimization of dosing regimens to treat drug-resistant tuberculosis.