Drug-resistant tuberculosis is a major global health challenge, treatment remains difficult. TB-PRACETAL has been investigating three oral only drug combinations; pretomanide, linezolid and bedaquiline with or without moxifloxacin or clofazimine.
A pharmacokinetic-pharmacodynamic study was nested into TB-PRACTECAL in order to investigate the relationship between the patients’ antibiotic exposure and sterilizing effects and treatment outcome. With this information we can inform optimization of dosing regimens to treat drug-resistant tuberculosis.
Nyang'wa BT, Kloprogge F, Moore DAJ, Bustinduy A, Motta I, Berry C, Davies GR. Population pharmacokinetics and pharmacodynamics of investigational regimens' drugs in the TB-PRACTECAL clinical trial (the PRACTECAL-PKPD study): a prospective nested study protocol in a randomised controlled trial. BMJ Open. 2021 Sep 6;11(9):e047185