Research to Improve Detection and Treatment of Latent TB Infection
Project Summary
Following declines in the incidence of TB during the 20th century, there was a resurgence of the disease in England from the late 1980s to 2005. Consequently, NHS England and Public Health England (PHE) launched a strategy in 2015 to bring about a sustained decline with screening for LTBI as a funded element of the plan.
LTBI testing and treatment reduces TB incidence by preventing reactivation and is expected to create a cost saving to the NHS after about five years (NHS England). However, high rates of testing, treatment uptake and treatment completion are essential prerequisites to accrue these benefits.
In this 5-year programme of research, we have designed studies to improve access to diagnosis and enhance treatment uptake and completion in individuals with or at risk of LTBI.
Through four interrelated work packages (WP) conducted in parallel, we combine a behavioural science theory-based approach together with clinical trials, health economics and modelling to assess our interventions and meet our objectives.
Studies are conducted in high-volume primary and secondary care settings in England.
We aim to:
- identify the factors influencing uptake of latent TB infection (LTBI) testing and completion of treatment among at-risk populations in the UK
- develop materials to communicate and support LTBI testing and treatment interventions
- evaluate the effectiveness and cost-effectiveness of a new Mycobacterium tuberculosis RD1-specific C-Tb skin test compared to interferon-gamma release-assay (IGRA), and
- assess the effectiveness and cost-effectiveness of a 12-dose rifapentine-based regimen with and without adherence support compared to current standard of care.
Key Project Information
Dates: 01/10/2018 - 30/06/2024
Status: Current
UCL lead/Principal Investigator: Professor Ibrahim Abubakar
Partners: UCL (Medical Research Council Clinical Trials Unit, School of Pharmacy, Institute for Global Health)
- Whittington
- Queen Mary University London
- Royal Free
- TB Alert
- SIIPL
- Sanofi
- Noclor
Location: England
- Currently recruiting at:
- Whittington Health NHS Trust
- Royal Free NHS Trust
- Barts Health NHS Trust (Shrewsbury Road, Mile End, Whipps Cross)
- Newham Transitional Practice
Funding: NIHR
Contact: Dr Molebogeng (Lele) Rangaka – Lead Investigator, IGH (l.rangaka@ucl.ac.uk)
- Research Team
Principal Investigator: Professor Ibrahim Abubakar
Lead Investigator: Dr Molebogeng (Lele) Rangaka
Co-investigators:
Dr Angela Crook - UCL MRC-Clinical Trials Unit
Professor Marc Lipman - Royal Free London NHS Foundation Trust
Dr Dominik Zenner - Queen Mary University of London
Professor Peter White - Imperial College London
Professor Rob Horne - UCL School of Pharamacy
Dr Penny Whiting - University of Bristol
Dr Heinke Kunst - Barts Health NHS Trust
Professor Chris Griffiths - Queen Mary University of LondonMike Mandelbaum - TB Alert
Clinical Research Fellow – Dr Yohhei Hamada
Research Nurses – TBCSenior Research Fellow - Dr Zoe Moon, UCL School of Pharmacy
Research Fellow – Aysenur Kilic, UCL School of Pharmacy
Clinical Project Manager – Karen Saunders, MRC-CTU at UCL
Trial Manager – Tessa Tattersall, MRC-CTU at UCL
Trial Manager – Ellen Owen Powell, MRC-CTU at UCL
Senior Statistician – Trinh Duong, MRC-CTU at UCLStatistician - Charlotte Layton, MRC, CTU at UCL
Data Manager – Kulpreet Kalsi, MRC-CTU at UCL
Publications
- Randomised controlled trial to evaluate the effectiveness of using the RD-1-based C-Tb skin test as a replacement for blood-based interferon-gamma release assay for detection of, and initiation of preventive treatment for, tuberculosis infection: RID-TB:Dx study protocol. BMJ Open, 11 (12), e050595. doi:10.1136/bmjopen-2021-050595
- Evaluating the effect of short-course rifapentine-based regimens with or without enhanced behaviour-targeted treatment support on adherence and completion of treatment for latent tuberculosis infection among adults in the UK (RID-TB:Treat): protocol for an open-label, multicentre, randomised controlled trial. BMJ Open in press
- Evaluating patient education resources for supporting treatment decisions in latent tuberculosis infection. Health Education Journal 2021, Vol. 80(5) 513–528