Data Collection on Adverse events of Anti-HIV Drugs (D:A:D)

Project Summary

The Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) was a prospective multi-cohort study of people with HIV.

The purpose of the study was to assess the incidence of several serious non-AIDS conditions (including cardiovascular disease, end-stage liver and renal disease and cancer) among people living with HIV and to describe their associations with anti-retroviral therapy (ART).

The collaboration included 11 cohorts worldwide, with a total sample size of >50,000 patients from 212 clinics in 33 countries in Europe, USA and Australia.

Although funding for the study has now finished, and no new data is being collected, analyses continue on the existing dataset, which includes information on risk factors for serious clinical events, HIV, demographic and lifestyle factors.

Key Project Information

Dates: 2001- 2017 (although analyses continue)

Status: Current

Principal Investigators: Prof Caroline Sabin (UCL)/Dr Lene Ryom (CHIP)

Lead organisation: Centre of Excellence for Health, Immunity and Infections (CHIP), University of Copenhagen

Location: UK, Denmark, Netherlands, France, Australia, Spain, Belgium, USA, Sweden, Italy, Switzerland.

Contact: Prof Caroline Sabin

Website: www.chip.dk/Studies/DAD

Research Team

UCL, UK: Prof Caroline Sabin, Prof Andrew Phillips, Dr Colette Smith

CHIP, Denmark: Prof Jens Lundgren, Dr Lene Ryom, Dr Camilla Hatleberg, Dr Ole Kirk.

Netherlands: Prof Peter Reiss.

Belgium: Prof Stephane de Wit.

Italy: Prof Antonella d’Arminio Monforte.

France: Prof Francois Dabis, Dr Fabrice Bonnet, Prof Christian Pradier.

Australia: Prof Matthew Law, Dr Kathy Petoumenos.

Switzerland: Prof Rainer Weber.

USA: Prof Wafaa El-Sadr.