Analysing humoral and cellular immune responses to vaccination during chronic infection
Studies of licensed vaccines such as the seasonal influenza virus vaccine present a valuable system to analyse post vaccine cellular and antibody responses. We are looking to recruit health care workers and HIV positive individuals who have not yet received their flu vaccine to investigate this further.
Who is eligible:
Individuals who are about to receive the flu vaccine and willing to give blood at three time points. These are: up to 30 days before their flu vaccination is administered, 7 days after, and 6 months after receiving the vaccine. We are also interested in recruiting HIV positive patients that meet the same criteria. Additionally, there will be a short questionnaire to complete at each visit.
Those co-infected with mycobacterium tuberculosis, Hepatitis B, Hepatitis C, Malaria. Also excluded are those with an AIDS Defining condition, undergoing concurrent cancer treatment, concurrent steroid treatment, pregnant or planning a pregnancy or with a previous allergic reaction to influenza vaccine/egg allergy.
If you are a potential participant in the study, you can contact a member of the study team to discuss joining the study – see Contact list on this page.
Links to other research
Other research from the UCL Centre for Clinical Research in Infection and Sexual Health
Other research from IGH in the UK