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TBTVACC: Developing a partnership to inform UK-Brazil TB control

Developing a partnership to inform UK-Brazil TB control. Investigating the efficacy of BCG vaccination following latent tuberculosis treatment

Project Summary

The overall aim of this collaboration is to develop a partnership that would bring together two major programmes of work in epidemiology in the UK and immunology in Brazil to inform the development of a major trial that would assess whether the efficacy of BCG vaccination in individuals with latent TB infection (LTBI) is improved by treating pre-existing latent infection.

The project includes a literature review, mathematical modelling and a pilot randomised controlled trial in Brazil on the efficacy of BCG following treatment of latent TB infection.


Key Project Information

Dates: 2015-2017

Principal Investigator: Prof Ibrahim Abubakar

Partners: London School of Hygiene and Tropical Medicine, FioCruz, University Federal Bahia

Location: Brazil

Funding: MRC and FAPESC

Contact: IGH.Director@ucl.ac.uk

Research Team

Ibrahim Abubakar

Lele Rangaka

Helen Stagg 

Charlotte Jackson