IGH supports ongoing global TB research

Projects 

WHO TB-IPD platform 

The TB treatment individual patient data platform (TB-IPD) is a collaborative initiative to support the generation of reliable evidence on the treatment of TB to inform future TB treatment guidelines. It is supported by the WHO Global TB Programme and maintained by UCL. 

The purpose of the TB-IPD is to facilitate pooling of individual patient data provided by researchers, or local or national tuberculosis programmes in the context of TB treatment and facilitate policy update, development and public health research. The platform is Led by Dr Lele Rangaka at IGH and Dr Ruth Goodall at ICTM.

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Research to Improve Detection and Treatment of Latent TB Infection (RID-TB)  

Led by Prof Ibrahim Abubakar and Dr Lele Rangaka.  RID-TB is a 5 year project designing studies to improve access to diagnosis and enhance the treatment uptake and completion in individuals with, or at risk of, latent TB infection (LTBI). 

The studies aim to evaluate the accessibility, readability and content of LTBI patient education resources.  

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Upcoming Events

World TB Day Symposium 2023 

Friday 24th March 2023, 10:00 - 18:00

Hybrid symposium based at London School for Hygiene and Tropical Medicine. 

Register here

UCL-TB Summer Networking Event 

Wednesday 14th June 2023 16:00 - 18:00

In-person networking event based in the Leolin Price Lecture Theatre and the Winter Gardens at the Institute for Child Health.

UCL-WHO TB Collaboration Centre

UCL are incredibly proud to announce the launch of a WHO TB Collaboration Centre.  WHO collaboration centres are designated by the Director-General and consist of institutions that carry out research or other activities that support the WHO's programmes. An official launch will be taking place in June with further details to be confirmed.

Recent publications

Health economic analyses of latent tuberculosis infection screening and preventive treatment among people living with HIV in lower tuberculosis incidence settings: a systematic review. (2023) Rebecca F. Baggaley, Carolin Vegvari, Christian A. Dimala, Marc Lipman, Robert F. Miller, James Brown, Svetlana Degtyareva, Helena A. White, T. Déirdre Hollingsworth, Manish Pareek 2023.  Wellcome Open Research, 6, p.51. https://doi.org/10.12688/wellcomeopenres.16604.2

Predictive performance of interferon-gamma release assays and the tuberculin skin test for incident tuberculosis: an individual participant data meta-analysis. (2023) Yohhei Hamada, Rishi K. Gupta, Matteo Quartagno, Abbie Izzard, Carlos Acuna-Villaorduna, Neus Altet, Roland Diel, Jose Dominguez, Sian Floyd, Amita Gupta, Helena Huerga, Edward C. Jones-López, Aarti Kinikar, Christoph Lange, Frank van Leth, Qiao Liu, Wei Lu, Peng Lu, Irene Latorre Rueda, Leonardo Martinez, Stanley Kimbung Mbandi, Laura Muñoz, Elisabeth Sánchez Padilla, Mandar Paradkar, Thomas Scriba, Martina Sester, Kwame Shanaube, Surendra K. Sharma, Rosa Sloot, Giovanni Sotgiu, Kannan Thiruvengadam, Richa Vashishtha, Ibrahim Abubakar, Molebogeng X. Rangaka, 2023. EClinicalMedicine, 56, p.101815  https://doi.org/10.1016/j.eclinm.2022.101815

Emergence of phenotypic and genotypic antimicrobial resistance in Mycobacterium tuberculosis. (2022) Frank Kloprogge, Julio Ortiz Canseco, Lynette Phee, Zahra Sadouki, Karin Kipper, Adam A. Witney, Neil Stoker, Timothy D. McHugh. Sci Rep 12(1): 21429 https://doi.org/10.1038/s41598-022-25827-6 

A multi-centre observational study of HIV, tuberculosis and risk of chronic lung disease in urban West Africa. (2022) Douglas L. Fink, David A. Oladele, Abigail J. Slack, Oluwatosin Adubela, Tomilola Musari-Martins, Adaobi Okechukwu, Kemi Adetayo, Sola Opaneye, Rufai Abubakar, Agatha Davidm James Cai, Shumonta Quaderi, Ibrahim Abubakar, Oliver Ezechi, John R.Hurst Marc Lipman, Babatunde Salako. AIDS 36(14): 1987-1995 https://doi.org/10.1097/QAD.0000000000003360 

Clinical utility of C-reactive protein-based triage for presumptive pulmonary tuberculosis in South African adults. (2023) Claire J Calderwood, Byron WP Reeve, Tiffeney Mann, Zaida Palmer, Georgina Nyawo, Hridesh Mishra, Gcobisa Ndlangalavu, Ibrahim Abubakar, Mahdad Noursadeghi, Grant Theron, Rishi K Gupta. J Infect 86(1): 24-32 https://doi.org/10.1016/j.jinf.2022.10.041 

High burden of childhood tuberculosis in migrants: a retrospective cohort study from the Thailand–Myanmar border. (2022) Amy Carroll, Banyar Maung Maung, Win Pa PA Htun, Wanitda Watthanaworawit, Michele Vincenti-Delmas, Colette Smith, Pam Sonnenberg, Francois Nosten. BMC Infectious Diseases, 22 , Article 608. 10.1186/s12879-022-07569-y. 

TB preventive treatment among pregnant women with HIV. (2022) DeAtley, T; Hamada, Y; Baddeley, A; Werner, P; Kanchar, A; Zignol, M; Rangaka, MX. International Journal of Tuberculosis and Lung Disease, 26 (8) pp. 727-732. 10.5588/ijtld.21.0477.

Ending the tuberculosis syndemic: is COVID-19 the (in)convenient scapegoat for poor progress? (2022) Molebogeng X Rangaka, Yohhei Hamada, Ibrahim Abubakar. The Lancet Respiratory Medicine 10.1016/S2213-2600(22)00123-0. (In press).

Tuberculosis diagnostics to reduce HIV-associated mortality: Barnett Christie Lecture 2020. (2022) Ankur Gupta-Wright. Clinical Infection in Practice, 15 , Article 100152. 10.1016/j.clinpr.2022.100152

Risk for development of active tuberculosis in patients with chronic airway disease-a-systematic review of evidence. (2022) Yohhei Hamada, Christopher J Fong, Andrew Copas, John R Hurst, Molebogeng X. Rangaka. Transactions of the Royal Society of Tropical Medicine and Hygiene , 116 (5) pp. 390-398. 10.1093/trstmh/trab122.