Investigation Of Drug Synergy And Rational Design Of Drug Combinations To Overcome Multidrug-Resistant
Antibiotic combination therapy plays an important role in combatting antibiotic resistance as it increases antibacterial spectrum and efficacy while decreasing the probability of emergence of resistance. Investigations of combinatory mechanism of action are therefore important to prioritise pathways for drug combination discovery programmes. However, only a limited number of studies aim to understand the mechanism of action and the biological basis for effective drug combinations. This project therefore integrates conventional in-vitro assays with transcriptomics and metabolomics in order to elucidate mechanisms underlying drug responses.