The nature of the work carried out in Genetic Epidemiology is dependent on establishing a network of specialists from diverse backgrounds, in order to create a vibrant reserach environment. We are engaged in conducting a breadth of projects from laboratory work and in house genotying, to large scale meta-analyses. We are also keen to develop innovative methodology to be able to deal with large amounts of genetic data that are now becoming available to establish how these genetic data will impact on human health.

We collaborate exensively with the following people/ groups

Professor Liam Smeeth Liam is Professor of Clinical Epidemiolgy at the London School of Hygiene and Tropical Medicine. His main research interests are disease aetiology, investigating this using data from primary care for epidemiological research, and the use of genetic research. His main disease areas of interest are cardiovascular.
Professor John Whittaker John is Professor of Genetic Epidemiology and Statistics at the London School of Hygiene and Tropical Medicine. His main research interests are the application of statistics in humans, population and quantitative genetics.
Dr Meena Kumari Meena is senior research fellow in the Department of Epidemiology and Public Health at UCL. She is lead for Genetics in the Whitehall II study and English Longitudal Study of Aging (ELSA). Her main research interests include the effects of stress on ageing and the development of cardiovascular disease and is involved in the examination of biological mechanisms that may mediate the inverse social gradient in cardiovascular morbidity and mortality. 

Professor's Steve Humphries and Philippa Talmud-

Centre for Cardiovascular Genetics

Steve is the head of the Centre for Cardiovasular Genetics and Philippa a PI within the centre. Their main interest is to identify the genetic factors that contribute to an individual's risk of developing coronary heart disease. Over the last few years their work has focussed increasingly on examining gene-environment interactions, particularly smoking, based on the prospective NPHSII study, and cohorts of patients with type 2 diabetes. Recently they have examined genes involved in inflammation and oxidative stress, and are measuring telomere length in house. Steve also heads an active group looking at the paradigm CHD mongenic disease of familial hypercholesterolaemia.
Professor's George Davey Smith, Debbie Lawlor and Yoav Ben-Schlomo
George, Debbie and Yoav are based in the Department of Social Medicine at Bristol University, a leading centre for teaching and research in epidemiology. The work of the department is collaborative and multi-discplinary. The department also  houses the MRC Centre for Causal Analysis in Translational Epidemiology (CAiTE); the premier birth cohort study, ALSPAC (Avon Longitudinal Study of Parents and Children); an NHS R&D Academic Support Unit; and (jointly with Primary Care) the Bristol Randomised Trials Collaboration, a UKCRC/NCRI-accredited trials unit.
Professor John Deanfield John is the BHF Vandervell Professor of Congenital Heart Disease and the Academic Head of the Academic Cardiac Unit at the Institute of Child Health. His research funded by the British Heart Foundation, aims to establish the first population-based study of vascular phenotype relevant in the initiation of atherosclerosis in the young, and to define genetic and environmental influences that will affect measures of endothelial dependent and independent vascular function.

Professor's Mark Caulfield and Patricia Munroe Mark and Patsy are based at the William Harvey Reserach Centre at Bart's and the London. Their interest is in determination of the molecular basis of hypertension. Together they co-ordinate the MRC British Genetics of Hypertension (BRIGHT).  BRIGHT is partnering Oxford Cambridge and the Sanger Centre to undertake pathfinder experiments for genome-wide association, as part of the Wellcome Trust Case Consortium. 
Professor Diana Kuh and Dr Andrew Wong

Diana is the Director of the MRC Unit for Lifelong Health and Ageing and of the MRC National Survey of Health and Development, her interests being life course epidemioloy. Diana uses data from the MRC National Survey of Health and Development to study how biological, psychological and social factors at different stages of life, independently, cumulatively or interactively affect adult physical capability and musculoskeletal function and their change with age. She also uses this life course approach to study women's health, cardiovascular health and wellbeing.

Andy is the Genetics Project Manager for the 1946 Birth Cohort. This study recruited individuals born in England, Scotland and Wales that occurred in one week in March 1946. Follow-up began at age 2 years and has continued since, a social class stratified sample (n=5362) was taken from all the responding population of married mothers having single births. This sample has been followed up 20 times since.

Professor Peter Whincup and Dr Richard Morris
Peter is chair of cardiovascular epidemiology at St George's Medical School,  Richard is a Reader in medical statistics and epidemiology at UCL. They are both involved with the the British Regional Heart Study, which is a prospective study in middle aged men drawn from general practices in 24 British towns, recruited in 1978-1980. The aim at set up was to determine factors which account for the variation in vascular outcomes in Great Britian, and to seek to determine the cause of these disease to provide a rational basis for recommendations towards their prevention.
Dr Manjinder Sandhu Manj is Reader at the Department of Public Health and Primary Care at Cambridge Univeristy. His research interests lie in investigating the genetics of complex diseases. 
Dr Nikolas Maniatis Nik is a Lecturer in Human Genetics at UCL, based in the Department of Genetics Evolution and Environment.
Professor Mika Kivimaki Mika is Professor of Social Epidemiology at UCL. He is a member of the Whitehall II Study team and the Cardiovascular Risk in Young Finns Study team. His reasearch aim is to increase understanding of modifiable risk factors and prognostic factors for adult-onset chronic diseases of public health relevance. He is also interested in determinants of functional limitations in later life.
Professor Shu Ye Shu is a Professor of Molecular Medicine and Genetics at the William Harvey Research Institute. His research interests are directed towards gaining a better understanding of the molecular basis of coronary artery disease and related traits.
Professor Christine Power and Dr Elina Hypponen Chris a Professor in public health and epidemiolgy and Elina a Reader in public health and epidemiology based in the MRC Centre of Epidemiolgy and Child  Health/ Paediatric epidemiology and biostatistics unit at the Institute of Child Health. They are  interested in life course and intergenerational influences on health and disease, with an emphasis on child to adult growth and health trajectories and early life influences on adult disease. This includes an extensive, well established and broad programme of work within ESRC, Medical Research Council and Wellcome Trust funded 1958 Birth Cohort, the Millenium Cohort and other populations.

Page last modified on 06 dec 10 11:43