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Genetic Association Studies and Mendelian Randomisation

Mendelian randomisation studies have become increasingly popular in the past decade following the growth in availability of genome-wide data.

Initially this one-day course will cover basic concepts behind genetic association studies with focus on Genome-Wide Association Studies (GWAS).

The practical component will take participants through quality controlling genetic datasets as well as using the latest statistical methods and software to analyse and visualise results for genome-wide data.

The second part of the course will then focus on Mendelian Randomisation (MR), and more specifically using genetic variants identified through GWAS to estimate the causal relationship of a non-genetic risk factor on an outcome of interest.

The practicals will be implemented in PLINK, HAPLOVIEW, R and Stata.

Outline Timetable

Time Activity Led by
09:00-09:30 Registration and coffee  
09:30-10:15 Introduction to genetic association studies and genome-wide association studies Ghazaleh Fatemifar
10:15-10:30 Coffee  
10:30-11:45 Practical: Genome-wide association studies Ghazaleh Fatemifar
11:45-12:45 Lunch  
12:45-13:30 Introduction to Mendelian randomisation Michail Katsoulis
13:30-14:15 Mendelian randomisation using individual-level data Michail Katsoulis
14:15-14:30 Coffee  
14:30-15:15 Practical: Mendelian randomisation using individual-level data Michail Katsoulis, Victoria Allan, Caroline Dale
15:15-16:00
Two-sample Mendelian randomisation
Michail Katsoulis
16:00-16:15
Coffee  
16:15-17:00
Practical: two-sample Mendelian randomisation
Michail Katsoulis, Victoria Allan

Course Team

Dr Ghazaleh Fatemifar (Lead Tutor)
Dr Michail Katsoulis (Lead Tutor)
Ms Victoria Allan
Dr Caroline Dale