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Farr Institute London Short Courses

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Genetic Association Studies and Mendelian Randomisation

Mendelian randomisation studies have become increasingly popular in the past decade following the growth in availability of genome-wide data.

Initially this two-day course will cover basic concepts behind genetic association studies with focus on Genome-Wide Association Studies (GWAS).

The practical component will take participants through quality controlling genetic datasets as well as using the latest statistical methods and software to analyse and visualise results for genome-wide data.

The second part of the course will then focus on Mendelian Randomisation (MR), and more specifically using genetic variants identified through GWAS to estimate the causal relationship of a non-genetic risk factor on an outcome of interest.

The practicals will be implemented in PLINK, HAPLOVIEW, R and Stata.

To participate fully in the practicals, participants will benefit from a basic knowledge of unix/linux and are encouraged to complete tutorials 1 & 2 of the material available at www.ee.surrey.ac.uk/Teaching/Unix/ in advance of the course.

Planned Timetable

Day 1

Time Session Title Led by
09:00-09:30 Registration and coffee  
09:30-10:15 Introduction to genetic association studies and genome-wide association studies  Dr Ghazaleh Fatemifar
10:15-10:45 Coffee  
10:45-12:30 Genome-wide association studies practical Dr Ghazaleh Fatemifar
Ms Victoria Garfield
12:30-13:15 Lunch  
13:15-14:15 Introduction to Mendelian Randomisation Dr Michail Katsoulis
14:15-15:00 Mendelian randomisation using individual-level data Dr Michail Katsoulis
15.00-15.15 Coffee
 
15.15-16.00 Mendelian randomisation using individual-level data (continued) Dr Tom Palmer
16:00-17:00 Practical: individual-level data Dr Tom Palmer,
Dr Michail Katsoulis,
Mr Okazie Uche-Ikonne

Day 2

Time Session Title Led by
09:30-10:15 Two-sample Mendelian randomisation Dr Michail Katsoulis
10:15-10:30 Coffee  
10:30-11:30 Two-sample Mendelian randomisation (continued) Dr Tom Palmer
11:30-12:45 Practical: Two-sample Mendelian randomisation Dr Tom Palmer,
Dr Michail Katsoulis,
Mr Okazie Uche-Ikonne
12:45-13:45 Lunch  
13:45-14:45 Non-linear Mendelian randomisation Dr Tom Palmer
14:45-15:45 Practical: Non-linear Mendelian randomisation  Dr Tom Palmer,
Dr Michail Katsoulis
15:45-16.00 Coffee  
16:00-17:00 Using genes for drug discovery Prof Aroon Hingorani

Course Team

Dr Ghazaleh Fatemifar (Lead Tutor)
Dr Michail Katsoulis (Lead Tutor)
Dr Tom Palmer (Lead Tutor)
Dr Caroline Dale
Ms Victoria Garfield
Prof Aroon Hingorani
Mr Okezie Uche-Ikonne