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Available out of hours. Contact the Media Relations Team +44 (0)20 7679 9041 or +44 (0)7917 271 364

Professor Kristjan Jessen

Professor Kristjan Jessen, BSc, MSc, PhD

Emeritus Professor of Cellular & Developmental Biology

Department : Cell & Developmental Biology

Faculty : Faculty of Life Sciences

Address : E6060 SIXTH FLOOR
MNH GOSH (4 ROOMS)
GREAT ORMOND STREET
LONDON
WC1N 3JH

Languages spoken fluently (other than English) : Icelandic

+44 (0)20 7679 3351

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Our work focuses on peripheral nerves, their development, response to damage and on their ability to regererate following injury. We are perticularily intrested in the glial cells (Schwann cells) that surround the neurites (axons) of nerves and support neuronal development, enable neurites to transmitt information and to regenerate after damage. We are also interested in genetic diseases of Schwann cells that destroy the insulating sheaths (myelin) that many Schwann cells form around axons.

Research groups:

http://www.ucl.ac.uk/jessenmirsky/

Research publications:

Woodhoo A, Duran Alonso MB, Droggiti A, Turmaine M, D’Antonio M, Parkinson DB, Wilton DK, R Al-Shawi, P Simons, J Shen, F Guillemot, F Radtke, Meijer D, Feltri ML, Wrabetz L, Mirsky R, Jessen KR. (2009) Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nature Neurosci 12: 839-847.

Jessen KR, Mirsky R.(2008) Negative regulation of myelination: relevance for development, injury, and demyelinating disease. Glia 56:1552-65.

Mirsky R and Jessen KR Development of Schwann cells. In: The New Encyclopedia of Neuroscience, Elsevier on-line.

Mirsky R, Woodhoo A, Parkinson DB, Arthur-Farraj P, Bhaskaran A and Jessen KR (2008) Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation. J Peripher Nerv Syst 13:122-135.

Agudo M, Woodhoo A, Webber D, Mirsky R, Jessen KR and McMahon SB (2008) Schwann cell precursors transplanted into the injured spinal cord multiply, integrate and are permissive for axon growth. Glia 56:1263-1270.

Parkinson DB, Bhaskaran A, Arthur-Farraj P, Noon LA, Woodhoo A, Lloyd AC, Feltri ML, Wrabetz L, Behrens A, Mirsky R and Jessen KR (2008) c-Jun is a negative regulator of myelination. J Cell Biol 181:625-637.

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