on cross-disciplinary global disability research.
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Contact: Sarah Ball, Tel: (internal x82 72 2352)
2011 Seminar Series
Speaker: Professor Jorge Erusalimsky, University of Wales Institute
Title: 'Endothelial cell senescence: evidence, mechanisms and the ageing
Date & Time: Friday 8th April
Venue: G37 & G38
Most mitotically competent mammalian cell types can react to stress by undergoing a phenotypically distinctive and permanent form of growth arrest called "cellular senescence." This response has been extensivelycharacterized in cell culture and more recently it has been found to occur also in vivo in association with ageing and age-related pathologies. In this lecture I will present the case for the occurrence of senescence in the vascular endothelium and will discuss the main mechanisms that modulate this process and its relevance to vascular ageing.
Jorge D. Erusalimsky was born in Buenos Aires, Argentina in 1954 and received his PhD degree in Biochemistry from the Hebrew University of Jerusalem, Israel in 1983. He came to the UK in 1985 as an EMBO fellow to work with Cesar Milstein at the laboratory of Molecular Biology. Currently, he is Professor of Biomedical Sciences and Head of the Cellular Senescence and Vascular Biology Research Group at the Cardiff School of Health Sciences, University of Wales Institute, Cardiff (UWIC) in the United Kingdom. He is also an Honorary Professor of University College London at the Wolfson Institute for Biomedical Research. Prof. Erusalimsky’s main research interests concentrate on the cellular and molecular mechanisms that underlie the relationship between ageing and cardiovascular diseases. His work in this area was among the first to demonstrate the occurrence of vascular cell senescence in vivo. Prof Erusalimsky’s current research activities include studying the roles that telomere integrity and sirtuins play in the control of endothelial cell senescence and cytoprotection. In addition, Prof. Erusalimsky has a long standing interest in megakaryocytopoiesis and platelet biogenesis. He has authored over 65 peer-reviewed publications and 4 patents.
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