2016

List of Whitehall II publications by Whitehall II researchers, ordered alphabetically by first author. This list includes consortia papers.

• Assessing cortisol from hair samples in a large observational cohort: The Whitehall II study. Abell JG, Stalder T, Ferrie JE, Shipley MJ, Kirschbaum C, Kivimäki M, Kumari M. Psychoneuroendocrinology,73:148-156, 2016 (PMID: 27498290)
• Association of chronic insomnia symptoms and recurrent extreme sleep duration over 10 years with well-being in older adults: a cohort study. Abell JG, Shipley MJ, Ferrie JE, Kivimäki M, Kumari M. BMJ Open, 6(2):e009501, 2016 (PMID: 26832429) 
• Recurrent short sleep, chronic insomnia symptoms and salivary cortisol: A 10-year follow-up in the Whitehall II study. Abell JG, Shipley MJ, Ferrie JE, Kivimäki M, Kumari M.  Psychoneuroendocrinology, 68:91-99, 2016 (PMID:26963375) 
• Little Change in Diet After Onset of Type 2 Diabetes, Metabolic Syndrome, and Obesity in Middle-Aged Adults: 11-Year Follow-up Study. Akbaraly TN, Tabak AG, Shipley MJ, Mura T, Singh-Manoux A, Ferrie JE, Batty GD, Kivimaki M. Diabetes Care, 39(3):e29-30, 2016 (PMID: 26740640)
• Sub-threshold depressive symptoms and brain structure: A magnetic resonance imaging study within the Whitehall II cohort. Allan CL, Sexton CE, Filippini N, Topiwala A, Mahmood A, Zsoldos E, Singh-Manoux A, Shipley MJ, Kivimaki M, Mackay CE, Ebmeier KP. J Affect Disord, 204:219-225, 2016 (PMID: 27372409)
• Trajectories of Unhealthy Behaviors in Midlife and Risk of Disability at Older Ages in the Whitehall II Cohort Study. Artaud F, Sabia S, Dugravot A, Kivimaki M, Singh-Manoux A, Elbaz A. J Gerontol A Biol Sci Med Sci. 2016 Nov; 71(11): 1500-1506 (PMID: 27034508)
• Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids. Beaney KE, Cooper JA, McLachlan S, Wannamethee SG, Jefferis BJ, Whincup P, Ben-Shlomo Y, Price JF, Kumari M, Wong A, Ong K, Hardy R, Kuh D, Kivimaki M, Kangas AJ, Soininen P, Ala-Korpela M, Drenos F, Humphries SE; UCLEB consortium. Cardiovasc Diabetol, 15:115, 2016 (PMID: 27549350)
• A statistical model to describe longitudinal and correlated metabolic risk factors: the Whitehall II prospective study. Breeze P, Squires H, Chilcott J, Stride C, Diggle PJ, Brunner E, Tabak A, Brennan A. J Public Health (Oxf). 2016 Dec 2;38(4):679-687. (PMID: 28158533)
• Underestimating the Alcohol Content of a Glass of Wine: The Implications for Estimates of Mortality Risk. Britton A, O'Neill D, Bell S. Alcohol Alcohol, 51(5):609-14, 2016 (PMID: 27261472)
• Healthy obesity is not safe obesity. Bell JA, Shipley MJ, Kivimäki M. Int J Obes (Lond), 40(8):1333, 2016 (PMID: 27133617)
• Twenty-year trajectories of alcohol consumption during midlife and atherosclerotic thickening in early old age: findings from two British population cohort studies. Britton A, Hardy R, Kuh D, Deanfield J, Charakida M, Bell S. BMC Med, 14(1):111, 2016 (PMID: 27473049)
• Country specific associations between social contact and mental health: evidence from civil servant studies across Great Britain, Japan and Finland. Cable N, Chandola T, Lallukka T, Sekine M, Lahelma E, Tatsuse T, Marmot MG. Public Health. 2016 Aug;137:139-46. (PMID  27040913)
• Role of psychosocial work factors in the relation between becoming a caregiver and changes in health behaviour: results from the Whitehall II cohort study. Dich N, Head J, Hulvej Rod N. J Epidemiol Community Health. 2016 Dec; 70(12): 1200-1206 (PMID: PMC5136689)
• The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Ehret GB, Ferreira T, Chasman DI, Jackson AU, Schmidt EM, Johnson T, Thorleifsson G, Luan J, Donnelly LA, Kanoni S, Petersen AK, Pihur V, Strawbridge RJ, Shungin D, Hughes MF, Meirelles O, Kaakinen M, Bouatia-Naji N (...), Kivimaki M (...) Newton-Cheh C, Munroe PB.. Nat Genet, 48(10):1171-84, 2016 (PMID: 27618452) 
• Comorbidity and work disability among employees with diabetes: Associations with risk factors in a pooled analysis of three cohort studies. Ervasti J, Kivimäki M, Dray-Spira R, Head J, Goldberg M, Pentti J, Jokela M, Vahtera J, Zins M, Virtanen M.  Scand J Public Health, 44(1):84-90, 2016 (PMID: 26392421)
• Psychosocial factors associated with work disability in men and women with diabetes: a pooled analysis of three occupational cohort studies.  Ervasti J, Kivimäki M, Dray-Spira R, Head J, Goldberg M, Pentti J, Jokela M, Vahtera J, Zins M, Virtanen M. Diabetic Medicine, 33(2):208-17, 2016 (PMID: 26036141)
• Socioeconomic gradient in work disability in diabetes: evidence from three occupational cohorts. Ervasti J, Kivimäki M, Dray-Spira R, Head J, Goldberg M, Pentti J, Jokela M, Vahtera J, Zins M, Virtanen M.  J Epidemiol Community Health,  70(2):125-31, 2016 (PMID: 26294769)
• Job insecurity and risk of diabetes: a meta-analysis of individual participant data. Ferrie JE, Virtanen M, Jokela M, Madsen IE, Heikkilä K, Alfredsson L, Batty GD, Bjorner JB, Borritz M, Burr H, Dragano N, Elovainio M, Fransson EI, Knutsson A, Koskenvuo M, Koskinen A, Kouvonen A, Kumari M, Nielsen ML, Nordin M, Oksanen T, Pahkin K, Pejtersen JH, Pentti J, Salo P, Shipley MJ, Suominen SB, Tabák A, Theorell T, Väänänen A, Vahtera J, Westerholm PJ, Westerlund H, Rugulies R, Nyberg ST, Kivimäki M; IPD-Work Consortium. CMAJ. 2016 Dec 6;188(17-18):E447-E455 (PMID: 27698195)
• Innate and adaptive immunity in the development of depression: An update on current knowledge and technological advances. Haapakoski R, Ebmeier KP, Alenius H, Kivimäki M.  Progress in Neuro-Psychopharmacology & Biological Psychiatry, 66, 63-72, 2016 (PMID: 26631274)
• Diurnal Cortisol Patterns, Future Diabetes, and Impaired Glucose Metabolism in the Whitehall II Cohort Study.  Hackett RA, Kivimäki M, Kumari M, Steptoe A.J Clin Endocrinol Metab, 101(2):619-25, 2016 (PMID: 26647151)
• Structural and functional aspects of social support as predictors of mental and physical health trajectories: Whitehall II cohort study. Hakulinen C, Pulkki-Råback L, Jokela M, E Ferrie J, Aalto AM, Virtanen M, Kivimäki M, Vahtera J, Elovainio M. J Epidemiol Community Health, 70(7):710-5, 2016 (PMID: 26767407)
• Long working hours and cancer risk: a multi-cohort study. Heikkila K, Nyberg ST, Madsen IE, de Vroome E, Alfredsson L, Bjorner JJ, Borritz M, Burr H, Erbel R, Ferrie JE, Fransson EI, Geuskens GA, Hooftman WE, Houtman IL, Jöckel KH, Knutsson A, Koskenvuo M, Lunau T, Nielsen ML, Nordin M, Oksanen T, Pejtersen JH, Pentti J, Shipley MJ, Steptoe A, Suominen SB, Theorell T, Vahtera J, Westerholm PJ, Westerlund H, Dragano N, Rugulies R, Kawachi I, Batty GD, Singh-Manoux A, Virtanen M, Kivimäki M. Br J Cancer, 114(7):813-8, 2016 (PMID: 26889978)
• Biomarkers of subclinical inflammation and increases in glycaemia, insulin resistance and beta-cell function in non-diabetic individuals: the Whitehall II study. Herder C, Færch K, Carstensen-Kirberg M, Lowe GD, Haapakoski R, Witte DR, Brunner EJ, Roden M, Tabák AG, Kivimäki M, Vistisen D. Eur J Endocrinol, 175(5):367-77, 2016 (PMID: 27491375)
• Are Changes in Heart Rate Variability in Middle-Aged and Older People Normative or Caused by Pathological Conditions? Findings From a Large Population-Based Longitudinal Cohort Study.  Jandackova VK, Scholes S, Britton A, Steptoe A.  Journal  of the American Heart Association, 12;5(2), 2016 (PMID: 26873682)
• Heart rate variability and depressive symptoms: a cross-lagged analysis over a 10-year period in the Whitehall II study. Jandackova VK, Britton A, Malik M, Steptoe A. Psychol Med, 46(10):2121-31, 2016 (PMID: 27181276)
• Evidence-based prevention and treatment of dementia. Kivimäki M, Batty GD. Lancet Neurol, 15(10):1005, 2016 (PMID: 27450473)
• Underweight as a risk factor for respiratory death in the Whitehall cohort study: exploring reverse causality using a 45-year follow-up.  Kivimäki M, Shipley MJ, Bell JA, Brunner EJ, Batty GD, Singh-Manoux A.  Thorax, 71(1):84-5, 2016 (PMID: 26253581)
• Changes Over Time in Absolute and Relative Socioeconomic Differences in Smoking: A Comparison of Cohort Studies From Britain, Finland, and Japan. Lahelma E, Pietiläinen O, Ferrie J, Kivimäki M, Lahti J, Marmot M, Rahkonen O, Sekine M, Shipley M, Tatsuse T, Lallukka T. Nicotine Tob Res, 18(8):1697-704, 2016 (PMID: 26764256)
• Leisure time physical activity and subsequent physical and mental health functioning among midlife Finnish, British and Japanese employees: a follow-up study in three occupational cohorts. Lahti J, Sabia S, Singh-Manoux A, Kivimäki M, Tatsuse T, Yamada M, Sekine M, Lallukka T.   BMJ Open, 6(1):e009788, 2016 (PMID: 26739736)
• The interaction between systemic inflammation and psychosocial stress in the association with cardiac troponin elevation: A new approach to risk assessment and disease prevention. Lazzarino AI, Hamer M, Gaze D, Collinson P, Rumley A, Lowe G, Steptoe A. Prev Med, 20;93:46-52, 2016 (PMID: 27663429)
• Structural and functional measures of social relationships and quality of life among older adults: does chronic disease status matter? Liao J, Brunner EJ. Quality Of Life Research, 25(1), 153-64, 2016 (PMID: 26143057)
• Adverse Childhood Experiences and Alcohol Consumption in Midlife and Early Old-Age. Leung JP, Britton A, Bell S.  Alcohol Alcohol, 51(3):331-8, 2016 (PMID: 26553290)
• New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.  Lu Y, Day FR, Gustafsson S, (...), Hingorani A, Jørgensen T, Jousilahti P, Kivimaki M, Kumari M, Laakso M, Langenberg C, (...)Loos RJ. Nat Commun, 1;7:10495, 2016  (PMID: 26833246)
• Replication and Characterization of Association between ABO SNPs and Red Blood Cell Traits by Meta-Analysis in Europeans.  McLachlan S, Giambartolomei C, White J, Charoen P, Wong A, Finan C, Engmann J, Shah T, Hersch M, Podmore C, Cavadino A, Jefferis BJ, Dale CE, Hypponen E, Morris RW, Casas JP, Kumari M, Ben-Shlomo Y, Gaunt TR, Drenos F, Langenberg C, Kuh D, Kivimaki M, Rueedi R, Waeber G, Hingorani AD, Price JF, Walker AP; UCLEB Consortium.  PLoS One, 11(6):e0156914, 2016 (PMID:  27280446)
• The InterLACE study: Design, data harmonization and characteristics across 20 studies on women's health. Mishra GD, Chung HF, Pandeya N, Dobson AJ, Jones L, Avis NE, Crawford SL, Gold EB, Brown D, Sievert LL, Brunner E, Cade JE, Burley VJ, Greenwood DC, Giles GG, Bruinsma F, Goodman A, Hayashi K, Lee JS, Mizunuma H, Kuh D, Cooper R, Hardy R, Obermeyer CM, Lee KA, Simonsen MK, Yoshizawa T, Woods NF, Mitchell ES, Hamer M, Demakakos P, Sandin S, Adami HO, Weiderpass E, Anderson D. Maturitas, 92:176-85, 2016 (PMID: 27621257)
• Marginal role for 53 common genetic variants in cardiovascular disease prediction. Morris RW, Cooper JA, Shah T, Wong A, Drenos F, Engmann J, McLachlan S, Jefferis B, Dale C, Hardy R, Kuh D, Ben-Shlomo Y, Wannamethee SG, Whincup PH, Casas JP, Kivimaki M, Kumari M, Talmud PJ, Price JF, Dudbridge F, Hingorani AD, Humphries SE; UCLEB Consortium. Heart, 102(20):1640-7, 2016 (PMID: 27365493)
• Job strain and informal caregiving as predictors of long-term sickness absence: A longitudinal multi-cohort study. Mortensen J, Dich N, Lange T, Alexanderson K, Goldberg M, Head J, Kivimäki M, Madsen IE, Rugulies R, Vahtera J, Zins M, Rod NH. Scand J Work Environ Health. 2017 Jan 1;43(1):5-14. Epub 2016 Aug 24 (PMID  27556905)
• A study of common Mendelian disease carriers across ageing British cohorts: meta-analyses reveal heterozygosity for alpha 1-antitrypsin deficiency increases respiratory capacity and height. North TL, Ben-Shlomo Y, Cooper C, Deary IJ, Gallacher J, Kivimaki M, Kumari M, Martin RM, Pattie A, Sayer AA, Starr JM, Wong A, Kuh D, Rodriguez S, Day IN.  J Med Genet, 53(4):280-8, 2016 (PMID: 26831755)
• Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis. Nüesch E, Dale C, Palmer TM, White J, Keating BJ, van Iperen EP, Goel A, Padmanabhan S, Asselbergs FW; EPIC-Netherland Investigators, Verschuren WM, Wijmenga C, Van der Schouw YT, Onland-Moret NC, Lange LA, Hovingh GK, Sivapalaratnam S, Morris RW, Whincup PH, Wannamethe GS, Gaunt TR, Ebrahim S, Steel L, Nair N, Reiner AP, Kooperberg C, Wilson JF, Bolton JL, McLachlan S, Price JF, Strachan MW, Robertson CM, Kleber ME, Delgado G, März W, Melander O, Dominiczak AF, Farrall M, Watkins H, Leusink M, Maitland-van der Zee AH, de Groot MC, Dudbridge F, Hingorani A, Ben-Shlomo Y, Lawlor DA; UCLEB Investigators, Amuzu A, Caufield M, Cavadino A, Cooper J, Davies TL; IN Day, Drenos F, Engmann J, Finan C, Giambartolomei C, Hardy R, Humphries SE, Hypponen E, Kivimaki M, Kuh D, Kumari M, Ong K, Plagnol V, Power C, Richards M, Shah S, Shah T, Sofat R, Talmud PJ, Wareham N, Warren H, Whittaker JC, Wong A, Zabaneh D, Davey Smith G, Wells JC, Leon DA, Holmes MV, Casas JP.  Int J Epidemiol. 45(6):1927-1937, 2016 (PMID: 25979724)
• Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Pattaro C, Teumer A, Gorski M, Chu AY, Li M, (...)  Köttgen A, Kao WH, Fox CS. Nat Commun. 2016 Jan 21;7:10023 (PMID  26831199)
• Blood Pressure and Fibrinogen Responses to Mental Stress as Predictors of Incident Hypertension over an 8-Year Period.  Steptoe A, Kivimäki M, Lowe G, Rumley A, Hamer M.  Ann Behav Med. 2016 Dec;50(6):898-906 (PMID: 27401000)
• Smoking, physical inactivity and obesity as predictors of healthy and disease-free life expectancy between ages 50 and 75: a multicohort study. Stenholm S, Head J, Kivimäki M, Kawachi I, Aalto V, Zins M, Goldberg M, Zaninotto P, Magnuson Hanson L, Westerlund H, Vahtera J. Int J Epidemiol 2016 45 (4): 1260-1270 (PMID: 27488415)
• Development of a novel walkability index for London, United Kingdom: cross-sectional application to the Whitehall II Study.  Stockton JC, Duke-Williams O, Stamatakis E, Mindell JS, Brunner E, Shelton NJ.  BMC Public Health, 16(1):416, 2016 (PMID: 27193078)
• Selecting instruments for Mendelian randomization in the wake of genome-wide association studies. Swerdlow DI, Kuchenbaecker KB, Shah S, Sofat R, Holmes MV, White J, Mindell JS, Kivimaki M, Brunner EJ, Whittaker JC, Casas JP, Hingorani AD. Int J Epidemiol. 2016 Oct;45(5):1600-1616. 2016 Jun 24.(PMID: 27342221)
• Socioeconomic status, education, and aortic stiffness progression over 5 years: the Whitehall II prospective cohort study. Trudel X, Shipley MJ, McEniery CM, Wilkinson IB, Brunner EJ. J Hypertens, 34(10):2038-44, 2016 (PMID: 27442790) 
• Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study. van der Laan SW, Fall T, Soumaré A, (...)  Hingorani AD, Lind L, Pedersen NL, de Graaf J, Kiemeney LA, Baumeister SE, Franco OH, Hofman A, Uitterlinden AG, Koenig W, Meisinger C, Peters A, Thorand B, Jukema JW, Eriksen BO, Toft I, Wilsgaard T, Onland-Moret NC, van der Schouw YT, Debette S, Kumari M, Svensson P, van der Harst P, Kivimaki M, Keating BJ, Sattar N, Dehghan A, Reiner AP, Ingelsson E, den Ruijter HM, de Bakker PI, Pasterkamp G, Ärnlöv J, Holmes MV, Asselbergs FW. J Am Coll Cardiol, 68(9):934-45, 2016 (PMID: 27561768)
• Decreased reaction time variability is associated with greater cardiovascular responses to acute stress. Wawrzyniak AJ, Hamer M, Steptoe A, Endrighi R. Psychophysiology, 53(5):739-48, 2016 (PMID: 26894967)
• Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis. White J, Sofat R, Hemani G, Shah T, Engmann J, Dale C, Shah S, Kruger FA, Giambartolomei C, Swerdlow DI, Palmer T, McLachlan S, Langenberg C, Zabaneh D, Lovering R, Cavadino A, Jefferis B, Finan C, Wong A, Amuzu A, Ong K, Gaunt TR, Warren H, Davies TL, Drenos F, Cooper J, Ebrahim S, Lawlor DA, Talmud PJ, Humphries SE, Power C, Hypponen E, Richards M, Hardy R, Kuh D, Wareham N, Ben-Shlomo Y, Day IN, Whincup P, Morris R, Strachan MW, Price J, Kumari M, Kivimaki M, Plagnol V, Whittaker JC; International Consortium for Blood Pressure (ICBP), Smith GD, Dudbridge F, Casas JP, Holmes MV, Hingorani AD; UCLEB Consortium.  Lancet Diabetes Endocrinol, 4(4):327-36, 2016 (PIMD: 26781229)
• Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase. Würtz P, Wang Q, Soininen P, Kangas AJ, Fatemifar G, Tynkkynen T, Tiainen M, Perola M, Tillin T, Hughes AD, Mäntyselkä P, Kähönen M, Lehtimäki T, Sattar N, Hingorani AD, Casas JP, Salomaa V, Kivimäki M, Järvelin MR, Davey Smith G, Vanhala M, Lawlor DA, Raitakari OT, Chaturvedi N, Kettunen J, Ala-Korpela M.    J Am Coll Cardiol, 67(10):1200-10, 2016 (PMID: 26965542)

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